{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:06:11Z","timestamp":1789103171891,"version":"build-2803163510"},"reference-count":36,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UAB School of Public Health Quetelet Endowment Professorship Fund","award":["UAB 001"],"award-info":[{"award-number":["UAB 001"]}]},{"award":["UAB 001"],"award-info":[{"award-number":["UAB 001"]}],"id":[{"id":"https:\/\/ror.org\/0229evh14","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008333","name":"University of Alabama at Birmingham","doi-asserted-by":"publisher","award":["001-SOPH"],"award-info":[{"award-number":["001-SOPH"]}],"id":[{"id":"10.13039\/100008333","id-type":"DOI","asserted-by":"publisher"}]},{"award":["001-SOPH"],"award-info":[{"award-number":["001-SOPH"]}],"id":[{"id":"https:\/\/ror.org\/008s83205","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Oncol.","Current Oncology"],"abstract":"<jats:p>Cervical cancer remains the leading cause of cancer-related mortality among women in Nepal, where national screening coverage is approximately 16%. This study evaluated the feasibility of a community-based, door-to-door self-sampling strategy for high-risk human papillomavirus (hrHPV) detection in an urban municipality of central Nepal and assessed hrHPV prevalence, genotype distribution, screening outcomes, and associated demographic factors. A cross-sectional study was conducted between September 2023 and May 2024 in Ward No. 3 of Lalitpur Metropolitan City. Women aged 30\u201360 years were recruited through trained community health workers, provided education and home-based self-sampling kits, and completed a demographic questionnaire. Dry cervical swabs from 418 participants were tested for hrHPV. Women with positive results underwent visual inspection with acetic acid (VIA), followed by colposcopy, biopsy when indicated, and thermal ablation for confirmed precancerous lesions. Overall participation was 64.1%, and hrHPV prevalence was 10.3%. Non-16\/18 hrHPV genotypes predominated (55.8%), followed by HPV16 (20.9%). Women aged &gt; 50 years were more likely to be hrHPV- and VIA-positive (OR = 7.39, p = 0.02). Six pre-cancer cases were identified: five cervical intraepithelial neoplasia (CIN1) and one CIN3 case. Community-based hrHPV self-sampling was found to be feasible and achieved effective linkage to triage and treatment, supporting its consideration for strengthening cervical cancer screening in Nepal.<\/jats:p>","DOI":"10.3390\/curroncol33090539","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:30:46Z","timestamp":1788777046000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Community-Based HPV Self-Sampling to Enhance Access to Cervical Cancer Prevention: A Continuum-of-Care Model from Urban Nepal"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8262-628X","authenticated-orcid":false,"given":"Shreekrishna","family":"Maharjan","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Patan Academy of Health Sciences (PAHS), Lalitpur 44700, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8432-4771","authenticated-orcid":false,"given":"Anamika","family":"Maharjan","sequence":"additional","affiliation":[{"name":"Nepal Fertility Care Center (NFCC), Gusingal, Sanepa, Lalitpur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushala K.","family":"Bista","sequence":"additional","affiliation":[{"name":"Nepal Fertility Care Center (NFCC), Gusingal, Sanepa, Lalitpur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2469-6128","authenticated-orcid":false,"given":"Pranali G.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitendra","family":"Pariyar","sequence":"additional","affiliation":[{"name":"Cancer Care Nepal and National Cancer Hospital, Lalitpur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0473-0326","authenticated-orcid":false,"given":"Pema","family":"Lhaki","sequence":"additional","affiliation":[{"name":"Nepal Fertility Care Center (NFCC), Gusingal, Sanepa, Lalitpur 44600, Nepal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7002-357X","authenticated-orcid":false,"given":"Sadeep","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2026, July 03). 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Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"100955","DOI":"10.1016\/j.lanmic.2024.100955","article-title":"Global prevalence of cervical human papillomavirus in women aged 50 years and older with normal cytology: A systematic review and meta-analysis","volume":"6","author":"Osmani","year":"2025","journal-title":"Lancet Microbe"}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/539\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:16:46Z","timestamp":1789100206000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":36,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["curroncol33090539"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33090539","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]}}}