{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T11:02:56Z","timestamp":1790074976892,"version":"4.0.1"},"reference-count":83,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:00:00Z","timestamp":1789776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Curr. Oncol.","Current Oncology"],"abstract":"<jats:p>Background: Breast cancer survivors frequently experience persistent sensory, psychosocial, and functional sequelae that may not be captured by pain measures alone. Understanding recovery trajectories throughout treatment and survivorship may help identify women at risk of long-term recovery-related difficulties. Objective: To investigate sensory, psychosocial, functional, and quality-of-life trajectories throughout breast cancer treatment. Methods: This prospective longitudinal study included women undergoing unilateral breast cancer surgery assessed at six time points before and after surgery, including before and after adjuvant treatments when applicable. Outcomes included sensory function, pain, upper-limb function, psychosocial variables, and quality of life. Results: Seventy-two women (57 \u00b1 11 years) were included. Despite stable pain intensity and self-reported sensitization symptoms, fear of movement increased (TSK-11: MD [95%CI] = +9[0;22]), quality of life deteriorated (FACT-B: 3\u201312 month MD [95%CI] = \u221210[\u221219;\u22121]), and upper-limb function initially worsened before partially recovering. Objective sensory alterations suggested dynamic changes in somatosensory processing but were not consistently accompanied by greater pain intensity or self-reported sensitization symptoms. Conclusions: Recovery after breast cancer treatment is multidimensional and cannot be adequately reflected by pain intensity alone. Multidimensional assessment may help identify women at risk of persistent recovery-related difficulties and support personalized survivorship care.<\/jats:p>","DOI":"10.3390\/curroncol33090567","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:04:17Z","timestamp":1790067857000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional Recovery Trajectories Throughout Breast Cancer Treatment and Survivorship: A Prospective Longitudinal Study"],"prefix":"10.3390","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7987-8884","authenticated-orcid":false,"given":"Laura","family":"Lorenzo-Gallego","sequence":"first","affiliation":[{"name":"Physiotherapy Department, Physiotherapy in Women\u2019s Health Research Group, Faculty of Physiotherapy, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Health Research\u2014IRYCIS, University Hospital of Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0487-4819","authenticated-orcid":false,"given":"Nicola S.","family":"Diciolla","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Physiotherapy in Women\u2019s Health Research Group, Faculty of Physiotherapy, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"Respiratory Research and Rehabilitation Laboratory\u2014Lab3R, School of Health Sciences\u2014ESSUA, University of Aveiro, 3810-193 Aveiro, Portugal"},{"name":"Institute of Biomedicine\u2013IBiMED, University of Aveiro, Campus Universit\u00e1rio de Santiago, Agras Do Crasto, 3810-193 Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7829-9597","authenticated-orcid":false,"given":"Fernando","family":"Ramos-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Medicine and Biomedical Sciences, Faculty of Physiotherapy, University of A Coru\u00f1a, 15006 A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0833-4083","authenticated-orcid":false,"given":"Virginia","family":"Prieto-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Physiotherapy in Women\u2019s Health Research Group, Faculty of Physiotherapy, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldina","family":"Couso-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Physiotherapy in Women\u2019s Health Research Group, Faculty of Physiotherapy, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"Department of Obstetrics and Gynecology, Pr\u00edncipe de Asturias University Hospital, 28805 Alcal\u00e1 de Henares, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-3130","authenticated-orcid":false,"given":"Mar\u00eda","family":"Torres-Lacomba","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Physiotherapy in Women\u2019s Health Research Group, Faculty of Physiotherapy, University of Alcal\u00e1, 28805 Alcal\u00e1 de Henares, Madrid, Spain"},{"name":"Ram\u00f3n y Cajal Institute of Health Research\u2014IRYCIS, University Hospital of Ram\u00f3n y Cajal, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,19]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global Cancer Statistics 2022: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.annonc.2023.11.016","article-title":"Early Breast Cancer: ESMO Clinical Practice Guideline for Diagnosis, Treatment and Follow-Up\u2606","volume":"35","author":"Loibl","year":"2024","journal-title":"Ann. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Pascual, M.C., Monta\u00f1o, J.J., Franch, P., S\u00e1nchez-Contador, C., and Ramos, M. (2022). Survival of Breast Cancer by Stage, Grade and Molecular Groups in Mallorca, Spain. J. Clin. Med., 11.","DOI":"10.3390\/jcm11195708"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"P\u00e9rez, C., Ochoa, D., S\u00e1nchez, N., Ballesteros, A.I., Santidri\u00e1n, S., L\u00f3pez, I., Mond\u00e9jar, R., Carnaval, T., Villoria, J., and Colomer, R. (2024). Pain in Long-Term Cancer Survivors: Prevalence and Impact in a Cohort Composed Mostly of Breast Cancer Survivors. Cancers, 16.","DOI":"10.3390\/cancers16081581"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41416-025-03059-5","article-title":"Systematic Review of Clinical Practice Guidelines for Long-Term Breast Cancer Survivorship: Assessment of Quality and Evidence-Based Recommendations","volume":"133","year":"2025","journal-title":"Br. J. Cancer"},{"key":"ref_6","first-page":"3607","article-title":"Risk Factors of Pain in Breast Cancer Survivors: A Systematic Review and Meta-Analysis","volume":"25","author":"Leysen","year":"2017","journal-title":"Support. Care Cancer"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Nishigami, T., Manfuku, M., and Lahousse, A. (2023). Central Sensitization in Cancer Survivors and Its Clinical Implications: State of the Art. J. Clin. Med., 12.","DOI":"10.3390\/jcm12144606"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/EJA.0000000000002285","article-title":"Chronic Pain after Major Breast Surgery: A Retrospective Cohort Study","volume":"42","author":"Rex","year":"2025","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.breast.2018.08.105","article-title":"Prevalence of Pain in Patients with Breast Cancer Post-Treatment: A Systematic Review","volume":"42","author":"Wang","year":"2018","journal-title":"Breast"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.bja.2020.04.088","article-title":"Prevalence and Intensity of Persistent Post-Surgical Pain Following Breast Cancer Surgery: A Systematic Review and Meta-Analysis of Observational Studies","volume":"125","author":"Wang","year":"2020","journal-title":"Br. J. Anaesth."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1002\/jso.25820","article-title":"Late Locoregional Complications Associated with Adjuvant Radiotherapy in the Treatment of Breast Cancer: Systematic Review and Meta-Analysis","volume":"121","author":"Kanda","year":"2020","journal-title":"J. Surg. Oncol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/jmwh.13012","article-title":"Long-Term Effects of Breast Cancer Surgery, Treatment, and Survivor Care","volume":"64","author":"Lovelace","year":"2019","journal-title":"J. Midwifery Women\u2019s Health"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Nobre, I., Silva, M.N., Franco, S., Rodrigues, B., Silva, P.F., Teixeira, P.J., and Carra\u00e7a, E.V. (2026). Longitudinal Predictor Analysis of Pain in Breast Cancer Survivors on Aromatase Inhibitors-the PAC-WOMAN Trial. Front. Pain Res., 7.","DOI":"10.3389\/fpain.2026.1700365"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/AJP.0000000000001073","article-title":"Increased Clinical Pain Locations and Pain Sensitivity in Women After Breast Cancer Surgery: Influence of Aromatase Inhibitor Therapy","volume":"38","author":"Zhu","year":"2022","journal-title":"Clin. J. Pain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11136-024-03884-w","article-title":"Systematic Review of the Needs and Health-Related Quality of Life Domains Relevant to People Surviving Cancer in Europe","volume":"34","author":"Garin","year":"2025","journal-title":"Qual. Life Res."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"The WHOQOL Group (1998). Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment. Psychol. Med., 28, 551\u2013558.","DOI":"10.1017\/S0033291798006667"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/pm\/pnaa363","article-title":"Psychological Factors Are Associated with Pain at All Time Frames After Breast Cancer Surgery: A Systematic Review with Meta-Analyses","volume":"22","author":"Moloney","year":"2021","journal-title":"Pain Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1245\/s10434-024-15682-2","article-title":"Persistent Pain After Breast Cancer Treatment, an Underreported Burden for Breast Cancer Survivors","volume":"31","author":"Strijbos","year":"2024","journal-title":"Ann. Surg. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s11764-022-01194-z","article-title":"Treating Persistent Pain after Breast Cancer: Practice Gaps and Future Directions","volume":"17","author":"Meeus","year":"2023","journal-title":"J. Cancer Surviv."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1080\/03007995.2018.1552042","article-title":"Current Understanding of the Mixed Pain Concept: A Brief Narrative Review","volume":"35","author":"Freynhagen","year":"2019","journal-title":"Curr. Med. Res. Opin."},{"key":"ref_21","first-page":"383","article-title":"Phenotyping of Chronic Pain in Breast Cancer Survivors: An Original Study Using the Cancer Pain Phenotyping (CANPPHE) Network Multidisciplinary International Guidelines","volume":"32","author":"Saracoglu","year":"2024","journal-title":"Support. Care Cancer"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1097\/j.pain.0000000000002324","article-title":"Chronic Nociplastic Pain Affecting the Musculoskeletal System: Clinical Criteria and Grading System","volume":"162","author":"Kosek","year":"2021","journal-title":"Pain"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12282-022-01420-7","article-title":"Predictors of Persistent Post-Surgical Pain Intensity and Interference at 1 Year after Breast Cancer Surgery: Assessing Central Sensitization, Central Sensitivity Symptoms, and Psychological Factors","volume":"30","author":"Manfuku","year":"2023","journal-title":"Breast Cancer"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.bja.2022.12.013","article-title":"Towards Precision Pain Medicine for Pain after Cancer: The Cancer Pain Phenotyping Network Multidisciplinary International Guidelines for Pain Phenotyping Using Nociplastic Pain Criteria","volume":"130","author":"Nijs","year":"2023","journal-title":"Br. J. Anaesth."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11926-012-0279-x","article-title":"Mechanisms of Chronic Pain in Osteoarthritis","volume":"14","author":"Schaible","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s11926-010-0131-0","article-title":"The Role of Quantitative Sensory Testing in the Evaluation of Musculoskeletal Pain Conditions","volume":"12","author":"Petzke","year":"2010","journal-title":"Curr. Rheumatol. Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.pain.2006.01.041","article-title":"Quantitative Sensory Testing in the German Research Network on Neuropathic Pain (DFNS): Standardized Protocol and Reference Values","volume":"123","author":"Rolke","year":"2006","journal-title":"Pain"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1093\/pm\/pnv105","article-title":"Quantitative Sensory Testing in Chronic Musculoskeletal Pain","volume":"17","author":"Uddin","year":"2016","journal-title":"Pain Med."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/aas.12641","article-title":"Association between Sensory Dysfunction and Pain 1 Week after Breast Cancer Surgery: A Psychophysical Study","volume":"60","author":"Andersen","year":"2016","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104709","DOI":"10.1016\/j.jpain.2024.104709","article-title":"From Breast Cancer Diagnosis to Survivorship: Analyzing Perioperative Biopsychosocial Phenotypes and Their Relationship to Pain on Long Term","volume":"26","author":"Dams","year":"2025","journal-title":"J. Pain"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"106281","DOI":"10.1016\/j.bbi.2026.106281","article-title":"Cytokines, Somatosensory Functioning, and Psychological Distress in Post-Breast Cancer Surgery Pain: A Longitudinal Study","volume":"133","author":"Meeus","year":"2026","journal-title":"Brain Behav. Immun."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10549-010-1278-0","article-title":"Association between Patient Reported Outcomes and Quantitative Sensory Tests for Measuring Long-Term Neurotoxicity in Breast Cancer Survivors Treated with Adjuvant Paclitaxel Chemotherapy","volume":"125","author":"Hershman","year":"2011","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1188\/18.ONF.483-495","article-title":"Pressure Pain Phenotypes in Women Before Breast Cancer Treatment","volume":"45","author":"Harte","year":"2018","journal-title":"Oncol. Nurs. Forum"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/micr.30064","article-title":"Improved Sensory Recovery with a Novel Dual Neurorrhaphy Technique for Breast Reconstruction with Free Muscle Sparing TRAM Flap Technique","volume":"37","author":"Puonti","year":"2017","journal-title":"Microsurgery"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jpain.2018.11.004","article-title":"Preoperative Psychosocial and Psychophysical Phenotypes as Predictors of Acute Pain Outcomes After Breast Surgery","volume":"20","author":"Schreiber","year":"2019","journal-title":"J. Pain"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/EDE.0b013e3181577511","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration","volume":"18","author":"Vandenbroucke","year":"2007","journal-title":"Epidemiology"},{"key":"ref_37","first-page":"105","article-title":"SEOM-GEICAM-SOLTI Clinical Guidelines for Early-Stage Breast Cancer (UPDATE 2025)","volume":"28","author":"Novoa","year":"2026","journal-title":"Clin. Transl. Oncol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jamaoncol.2016.4851","article-title":"A Standard Set of Value-Based Patient-Centered Outcomes for Breast Cancer: The International Consortium for Health Outcomes Measurement (ICHOM) Initiative","volume":"3","author":"Ong","year":"2017","journal-title":"JAMA Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/EJA.0000000000001974","article-title":"Chronic Postsurgical Pain: A European Survey","volume":"41","author":"Martinez","year":"2024","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/AJP.0000000000000136","article-title":"Test-Retest Agreement and Reliability of Quantitative Sensory Testing 1 Year after Breast Cancer Surgery","volume":"31","author":"Andersen","year":"2015","journal-title":"Clin. J. Pain"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/j.1532-2149.2012.00190.x","article-title":"Temporal Summation of Second Pain: Variability in Responses to a Fixed Protocol","volume":"17","author":"Anderson","year":"2013","journal-title":"Eur. J. Pain"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e1176","DOI":"10.1097\/PR9.0000000000001176","article-title":"A Myriad of Methods to Determine Temporal Summation of Pain in People with Musculoskeletal Pain and Healthy Participants: A Scoping Review","volume":"9","author":"Kielstra","year":"2024","journal-title":"Pain Rep."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/j.pain.0000000000000497","article-title":"Pressure-Induced Referred Pain Is Expanded by Persistent Soreness","volume":"157","author":"Palsson","year":"2016","journal-title":"Pain"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/ejp.605","article-title":"Recommendations on Practice of Conditioned Pain Modulation (CPM) Testing","volume":"19","author":"Yarnitsky","year":"2015","journal-title":"Eur. J. Pain"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1186\/s40064-016-3515-4","article-title":"Cross-Cultural Adaptation and Validity of the Spanish Central Sensitization Inventory","volume":"5","author":"Neblett","year":"2016","journal-title":"SpringerPlus"},{"key":"ref_46","first-page":"487","article-title":"Validation of the Spanish version of the Pain Catastrophizing Scale in fibromyalgia","volume":"131","author":"Rodero","year":"2008","journal-title":"Med. Clin."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4321\/S1578-84232013000100009","article-title":"Validaci\u00f3n de La Escala de Catastrofismo Ante El Dolor (Pain Catastrophizing Scale) En Deportistas Espa\u00f1oles","volume":"13","year":"2013","journal-title":"Cuad. Psicol. Deporte"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jpain.2010.08.004","article-title":"Psychometric Properties of the Spanish Version of the Tampa Scale for Kinesiophobia (TSK)","volume":"12","year":"2011","journal-title":"J. Pain"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7525-8-37","article-title":"Validation of the Spanish Version of the Chronic Pain Acceptance Questionnaire (CPAQ) for the Assessment of Acceptance in Fibromyalgia","volume":"8","author":"Rodero","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"de la Rosa-D\u00edaz, I., Barrero-Santiago, L., Acosta-Ram\u00edrez, P., Mart\u00edn-Peces-Barba, M., Iglesias-Hern\u00e1ndez, E., Plisset, B., Lutinier, N., Belzanne, M., La Touche, R., and Grande-Alonso, M. (2022). Cross-Sectional Comparative Study on Central Sensitization-Psychosocial Associated Comorbidities and Psychological Characteristics in Breast Cancer Survivors with Nociceptive Pain and Pain with Neuropathic Features and without Pain. Life, 12.","DOI":"10.3390\/life12091328"},{"key":"ref_51","first-page":"126","article-title":"Efficacy of Acceptance and Commitment Therapy (ACT) on Depression, Pain Acceptance, and Psychological Flexibility in Married Women with Breast Cancer: A Pre- and Post-Test Clinical Trial","volume":"43","author":"Ghorbani","year":"2021","journal-title":"Trends Psychiatry Psychother."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/papr.13163","article-title":"Validation of Pain Catastrophizing Scale on Breast Cancer Survivor","volume":"22","author":"Pajares","year":"2022","journal-title":"Pain Pract."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.medcli.2010.11.028","article-title":"Validaci\u00f3n de La Versi\u00f3n Espa\u00f1ola Del Functional Assessment of Cancer Therapy Questionnaire for Breast Cancer (FACT-B+4)","volume":"137","author":"Boronat","year":"2011","journal-title":"Med. Clin."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S0025-7753(03)73601-X","article-title":"Validation of the Spanish Version of the Brief Pain Inventory in Patients with Oncological Pain","volume":"120","author":"Badia","year":"2003","journal-title":"Med. Clin."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.suponc.2010.12.004","article-title":"Estimating Minimally Important Differences for the Worst Pain Rating of the Brief Pain Inventory-Short Form","volume":"9","author":"Mathias","year":"2011","journal-title":"J. Support. Oncol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s12955-015-0256-y","article-title":"Spanish Cultural Adaptation and Validation of the Shoulder Pain and Disability Index, and the Oxford Shoulder Score after Breast Cancer Surgery","volume":"13","year":"2015","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_57","first-page":"505","article-title":"Validity and Reliability of the Spanish-Language Version of the Self-Administered Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) Pain Scale","volume":"33","year":"2018","journal-title":"Neurologia"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Lorenzo-Gallego, L., Arranz-Mart\u00edn, B., Romay-Barrero, H., Prieto-G\u00f3mez, V., Lluch, E., and Torres-Lacomba, M. (2022). Changes in Pain Sensitivity in Treatment for Breast Cancer: A 12-Month Follow-Up Case Series. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph19074055"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.jclinepi.2013.03.017","article-title":"Multiple Imputation of Missing Values Was Not Necessary before Performing a Longitudinal Mixed-Model Analysis","volume":"66","author":"Twisk","year":"2013","journal-title":"J. Clin. Epidemiol."},{"key":"ref_60","first-page":"3177","article-title":"Psychological Distress and Health-Related Quality of Life among Women with Breast Cancer: A Descriptive Cross-Sectional Study","volume":"30","author":"Phoosuwan","year":"2022","journal-title":"Support. Care Cancer"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"198","DOI":"10.5505\/aot.2021.38243","article-title":"Kinesiophobia in Breast Cancer Survivors and Its Relationship with Quality of Life, Comorbidity, and Other Clinical Parameters","volume":"54","author":"Sunar","year":"2021","journal-title":"Acta Haematol. Oncol. Turc."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e2072","DOI":"10.1002\/pri.2072","article-title":"Cross-Sectional and Longitudinal Analysis of Conditioned Pain Modulation and Pain in Fibromyalgia: CPM as an Effect Modifier of Pain Changes over Time","volume":"29","author":"Gianlorenco","year":"2024","journal-title":"Physiother. Res. Int."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jpainsymman.2012.06.016","article-title":"Alteration in Pain Modulation in Women with Persistent Pain after Lumpectomy: Influence of Catastrophizing","volume":"46","author":"Edwards","year":"2013","journal-title":"J. Pain Symptom Manag."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"596","DOI":"10.21037\/gs.2020.03.20","article-title":"The Impact of Radiation on Lymphedema: A Review of the Literature","volume":"9","author":"Allam","year":"2020","journal-title":"Gland Surg."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/NCC.0b013e3181c75f2a","article-title":"Trajectories of Fatigue in Patients with Breast Cancer Before, During, and After Radiation Therapy","volume":"33","author":"Dhruva","year":"2010","journal-title":"Cancer Nurs."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Hajj, A., Chamoun, R., Salameh, P., Khoury, R., Hachem, R., Sacre, H., Chahine, G., Kattan, J., and Rabbaa Khabbaz, L. (2022). Fatigue in Breast Cancer Patients on Chemotherapy: A Cross-Sectional Study Exploring Clinical, Biological, and Genetic Factors. BMC Cancer, 22.","DOI":"10.1186\/s12885-021-09072-0"},{"key":"ref_67","first-page":"143","article-title":"Association between Chemotherapy and the Risk of Developing Breast Cancer-Related Lymphedema: A Nationwide Retrospective Cohort Study","volume":"33","author":"Jeong","year":"2025","journal-title":"Support. Care Cancer"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Malchrowicz-Mo\u015bko, E. (2022). Kinesiophobia among Breast Cancer Survivors One Year after Hospital Treatment. Int. J. Environ. Res. Public Health, 19.","DOI":"10.3390\/ijerph192114565"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Monteiro, A.J., de Labra, C., Losa-Iglesias, M.E., Dias, A., Becerro-de-Bengoa-Vallejo, R., Silva-Migueis, H., Macedo, F., L\u00f3pez-L\u00f3pez, D., and G\u00f3mez-Salgado, J. (2024). The Relationship of Kinesiophobia in Patients with Lymphedema: A Case-Control Investigation. Front. Psychiatry, 15.","DOI":"10.3389\/fpsyt.2024.1293614"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2174\/1570159X20666221012112725","article-title":"Central Sensitization and Pain: Pathophysiologic and Clinical Insights","volume":"22","author":"Curatolo","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ejp.2257","article-title":"Continuum of Somatosensory Profiles in Breast Cancer Survivors with and without Pain, Compared to Healthy Controls and Patients with Fibromyalgia","volume":"28","author":"Haenen","year":"2024","journal-title":"Eur. J. Pain"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbi.2016.04.001","article-title":"Why Sickness Hurts: A Central Mechanism for Pain Induced by Peripheral Inflammation","volume":"57","author":"Karshikoff","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central Sensitization: Implications for the Diagnosis and Treatment of Pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"e085510","DOI":"10.1136\/bmjopen-2024-085510","article-title":"Coping with Cancer Pain: A Qualitative Study to Explore Pain Perception and Self-Coping Strategies of Patients with Cancer in Sri Lanka","volume":"14","author":"Edirisinghe","year":"2024","journal-title":"BMJ Open"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/ene.12353","article-title":"Characterization and Diagnostic Evaluation of Chronic Polyneuropathies Induced by Oxaliplatin and Docetaxel Comparing Skin Biopsy to Quantitative Sensory Testing and Nerve Conduction Studies","volume":"21","author":"Qvortrup","year":"2014","journal-title":"Eur. J. Neurol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/mus.21874","article-title":"Early, Progressive, and Sustained Dysfunction of Sensory Axons Underlies Paclitaxel-Induced Neuropathy","volume":"43","author":"Park","year":"2011","journal-title":"Muscle Nerve"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s10549-020-06079-2","article-title":"Characterization of Chemotherapy-Induced Peripheral Neuropathy Using Patient-Reported Outcomes and Quantitative Sensory Testing","volume":"186","author":"Zhi","year":"2021","journal-title":"Breast Cancer Res. Treat."},{"key":"ref_78","first-page":"4465","article-title":"Biopsychosocial Risk Factors for Pain and Pain-Related Disability 1 Year after Surgery for Breast Cancer","volume":"30","author":"Dams","year":"2022","journal-title":"Support Care Cancer"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.jpain.2017.05.002","article-title":"The Relationship Between Sensory Loss and Persistent Pain 1 Year After Breast Cancer Surgery","volume":"18","author":"Andersen","year":"2017","journal-title":"J. Pain"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jpain.2023.09.002","article-title":"Conditioned Pain Modulation and Temporal Summation of Pain in Patients with Traumatic and Non-Specific Neck Pain: A Systematic Review and Meta-Analysis","volume":"25","author":"Runge","year":"2024","journal-title":"J. Pain"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"102517","DOI":"10.1016\/j.cpr.2024.102517","article-title":"The Influence of Expectations and Attention on Conditioned Pain Modulation: A Systematic Review and Meta-Analysis","volume":"114","author":"Billens","year":"2024","journal-title":"Clin. Psychol. Rev."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1177\/20494637241229970","article-title":"The Association between Conditioned Pain Modulation and Psychological Factors in People with Chronic Spinal Pain: A Systematic Review","volume":"18","author":"Mansfield","year":"2024","journal-title":"Br. J. Pain"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/papr.13083","article-title":"Adaptive Body Awareness Predicts Fewer Central Sensitization-Related Symptoms and Explains Relationship between Central Sensitization-Related Symptoms and Pain Intensity: A Cross-Sectional Study among Individuals with Chronic Pain","volume":"22","author":"Colgan","year":"2021","journal-title":"Pain Pract."}],"container-title":["Current Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/567\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:16:37Z","timestamp":1790072197000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1718-7729\/33\/9\/567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,19]]},"references-count":83,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,9]]}},"alternative-id":["curroncol33090567"],"URL":"https:\/\/doi.org\/10.3390\/curroncol33090567","relation":{},"ISSN":["1718-7729"],"issn-type":[{"value":"1718-7729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,19]]}}}