{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:52Z","timestamp":1760147092407,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Composite hemangioendothelioma (CHE) is a very rare low-grade malignant vascular neoplasm. Here, we present the first case of it occurring on a penis with two local recurrences over a 9 year span and its progression to a high-grade morphology.<\/jats:p>","DOI":"10.3390\/dermatopathology10010005","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T04:29:38Z","timestamp":1673497778000},"page":"41-45","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multiply Recurrent Composite Hemangioendothelioma of Penis with Histologic Progression to High-Grade Features"],"prefix":"10.3390","volume":"10","author":[{"given":"Chau M.","family":"Bui","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonnie","family":"Balzer","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000478-200003000-00003","article-title":"Composite hemangioendothelioma: A complex, low-grade vascular lesion mimicking angiosarcoma","volume":"24","author":"Nayler","year":"2000","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Rokni, G.R., Montazer, F., Sharifian, M., and Goldust, M. (2017). Composite hemangioendothelioma of the forehead and right eye; a case report. BMC Dermatol., 17.","DOI":"10.1186\/s12895-017-0067-4"},{"key":"ref_3","unstructured":"Goldblum, J.R., Lamps, L.W., McKenney, J.K., and Myers, J.L. (2018). Rosai and Ackerman\u2019s Surgical Pathology, Mosby Inc.. [11th ed.]."},{"key":"ref_4","first-page":"1935","article-title":"Composite hemangioendothelioma arising from the kidney: A case report with review of the literature","volume":"6","author":"Zhang","year":"2013","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.kjms.2012.04.021","article-title":"Composite hemangioendothelioma on the neck","volume":"28","author":"Chen","year":"2012","journal-title":"Kaohsiung J. Med. 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Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1097\/PAS.0b013e31815bf8e6","article-title":"Epithelioid hemangioendothelioma of soft tissue: A proposal for risk stratification based on 49 cases","volume":"32","author":"Deyrup","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/PAS.0000000000000511","article-title":"Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics","volume":"40","author":"Doyle","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1097\/PAS.0000000000001575","article-title":"Recurrent YAP1 and MAML2 Gene Rearrangements in Retiform and Composite Hemangioendothelioma","volume":"44","author":"Antonescu","year":"2020","journal-title":"Am. J. Surg. 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