{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T01:44:23Z","timestamp":1777254263966,"version":"3.51.4"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T00:00:00Z","timestamp":1676246400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Post-pemphigus acanthomas have been rarely discussed in the literature. A prior case series identified 47 cases of pemphigus vulgaris and 5 cases of pemphigus foliaceus, out of which 13 developed acanthomata as a part of the healing process. Additionally, a case report by Ohashi et al. reported similar recalcitrant lesions on the trunk of a patient with pemphigus foliaceus being treated with prednisolone, IVIG, plasma exchange, and cyclosporine. Some view post-pemphigus acanthomas as variants of hypertrophic pemphigus vulgaris, being difficult to diagnose when they present as only single lesions, with a clinical differential of an inflamed seborrheic keratosis or squamous cell carcinoma. Here, we present a case of a 52-year-old female with a history of pemphigus vulgaris and four months of only topical therapy (fluocinonide 0.05%) who presented with a painful, hyperkeratotic plaque on the right mid-back that was found to be a post-pemphigus acanthoma.<\/jats:p>","DOI":"10.3390\/dermatopathology10010012","type":"journal-article","created":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T06:09:21Z","timestamp":1676268561000},"page":"86-90","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Post-Pemphigus Acanthomata Presenting as an Isolated, Hyperkeratotic Plaque"],"prefix":"10.3390","volume":"10","author":[{"given":"Rachita","family":"Pandya","sequence":"first","affiliation":[{"name":"California University of Science and Medicine, Colton, CA 92324, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjia","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Loma Linda University, Loma Linda, CA 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4655-8590","authenticated-orcid":false,"given":"Mansee","family":"Desai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Loma Linda University, Loma Linda, CA 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Loma Linda University, Loma Linda, CA 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Elsensohn","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Loma Linda University, Loma Linda, CA 92354, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/S0190-9622(88)70128-0","article-title":"Pemphigus","volume":"18","author":"Korman","year":"1988","journal-title":"Am. Acad. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1046\/j.1365-4362.1997.00092.x","article-title":"Postpemphigus acanthomata: A sign of clinical activity?","volume":"36","author":"Yesudian","year":"1997","journal-title":"Int. J. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1111\/ced.14141","article-title":"Verrucous variant of pemphigus foliaceus","volume":"45","author":"Ohashi","year":"2020","journal-title":"Clin. Exp. Dermatol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.abd.2022.01.007","article-title":"Recalcitrant vegetative and nodular scalp lesions on the vertex in pemphigus patients: An immunocompromised district?","volume":"98","author":"Kucukoglu","year":"2023","journal-title":"An. Bras. Dermatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1111\/bjd.15930","article-title":"British Association of Dermatologists\u2019 guidelines for the management of pemphigus vulgaris 2017","volume":"177","author":"Harman","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.compbiomed.2015.12.024","article-title":"Differential diagnosis of squamous cell carcinoma in situ using skin histopathological images","volume":"70","author":"Noroozi","year":"2016","journal-title":"Comput. Biol. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4103\/2229-5178.178090","article-title":"Hailey-Hailey disease","volume":"7","author":"Kar","year":"2016","journal-title":"Indian Dermatol. Online J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.4103\/0378-6323.102355","article-title":"Immunofluorescence in dermatology","volume":"78","author":"Chhabra","year":"2012","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0190-9622(94)70060-5","article-title":"Pemphigus in remission: Value of negative direct immunofluorescence in management","volume":"30","author":"Ratnam","year":"1994","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/10\/1\/12\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:32:50Z","timestamp":1760121170000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/10\/1\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3]]}},"alternative-id":["dermatopathology10010012"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology10010012","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,13]]}}}