{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T18:46:58Z","timestamp":1764874018250,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T00:00:00Z","timestamp":1678320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>A novel type of cell underwent identification between 2005 and 2008 and was denominated the \u201ctelocyte\u201d in 2010. In 2012, transmission electron microscopy revealed the presence of telocytes in the dermis. The aim of the present study was to report important changes in immunostained CD34 cells following the treatment of lower limb lymphedema using a specific lymphatic therapy technique. A clinical trial involving the evaluation of changes in immunostained CD34 cells in the epidermis and dermis (10 randomly selected histological fields) of a patient before and after intensive treatment for clinical stage II lymphedema was conducted using the Godoy Method, which was adapted to the treatment of skin fibrosis. The evaluation involved the use of the Weibel multi-point morphometric method. Comparisons were performed using the t-test with a 95% significance level. An important increase in CD34 cells was found with redistribution occurring following treatment. The treatment of primary lymphedema of the lower limbs resulted in the clinical reversal of fibrosis and an increase in the number of immunomarked CD34 cells.<\/jats:p>","DOI":"10.3390\/dermatopathology10010016","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T03:03:23Z","timestamp":1678331003000},"page":"104-111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and Physiological Remodeling of CD34 Cells in the Skin following the Reversal of Fibrosis through Intensive Treatment for Lower Limb Lymphedema: A Case Report"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7787","authenticated-orcid":false,"given":"Jose Maria","family":"Pereira de Godoy","sequence":"first","affiliation":[{"name":"Department of the Medicine School, S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), CNPq (National Council for Research and Development), Sao Jose do Rio Preto 15090-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Pereira de Godoy","sequence":"additional","affiliation":[{"name":"Research Group of the Cl\u00ednica Godoy, Intensive Surgery Pediatric Cardiac, Hospital da Crian\u00e7a e Maternidade\u2014HCM, Medicine School of Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-7961","authenticated-orcid":false,"given":"Maria de Fatima","family":"Guerreiro Godoy","sequence":"additional","affiliation":[{"name":"Research Group in the Cl\u00ednica Godoy, Medicine School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalisio","family":"de Santi Neto","sequence":"additional","affiliation":[{"name":"Hospital de Base, Medicine School of S\u00e3o Jos\u00e9 do Rio Preto (FAMERP), Sao Jose do Rio Preto 15090-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1515\/BMC.2011.039","article-title":"Telocytes","volume":"2","author":"Pellegrini","year":"2011","journal-title":"Biomol. 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