{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T03:03:52Z","timestamp":1794020632551,"version":"4.8.0"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Spiny keratoderma (SK) was first described by Brown in 1871 and is characterized by numerous 1\u20132 mm spines of keratin on the palms and soles, usually sparing the dorsal surfaces, or disseminated over the trunk. Histologically, the \u201cspine\u201d represents a column of hyperkeratosis. Several different forms are known, including familial, sporadic, post-inflammatory and paraneoplastic. Although an association of SK with melanoma has been reported, the significance of such co-occurrence remains unclear due to the limited number of cases. To increase the body of knowledge and shed further light on this rare condition, we present a case of SK in a patient with a recent history of melanoma in situ.<\/jats:p>","DOI":"10.3390\/dermatopathology10020021","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T03:57:32Z","timestamp":1684727852000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Spiny Keratoderma in Association with Melanoma"],"prefix":"10.3390","volume":"10","author":[{"given":"Tatsiana","family":"Pukhalskaya","sequence":"first","affiliation":[{"name":"Department of Pathology, Dermatopathology and Oral Pathology Services, University of California San Francisco, San Francisco, CA 94115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaddeus W.","family":"Mully","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dermatopathology and Oral Pathology Services, University of California San Francisco, San Francisco, CA 94115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-1921","authenticated-orcid":false,"given":"Maria L.","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Francisco, San Francisco, CA 94115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/archderm.1971.04000240106016","article-title":"Punctate keratoderma","volume":"104","author":"Brown","year":"1971","journal-title":"Arch. 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