{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T21:02:50Z","timestamp":1765486970977,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T00:00:00Z","timestamp":1694131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Lichen Planus Pigmentosus (LPP) is an uncommon variant of lichen planus characterized by the development of dark greyish-brown macules and patches primarily affecting sun-exposed areas. Histologically, it presents with lichenoid interface dermatitis with many melanophages. In select cases, the presence of melanocytic nests or pseudomelanocytic nests within LPP lesions has been documented, posing a diagnostic challenge. We present a detailed case report of a 32-year-old Eritrean woman with a longstanding history of hyperpigmented macules, alongside an in-depth review of the existing literature on lichenoid dermatoses featuring melanocytic or pseudomelanocytic nests. This paper delves into the clinical presentation, histopathological features, differential diagnosis, and potential mechanisms underlying this intriguing phenomenon.<\/jats:p>","DOI":"10.3390\/dermatopathology10030036","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T08:01:30Z","timestamp":1694160090000},"page":"281-286","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lichen Planus Pigmentosus with True Melanocytic Nests: A Case Report with a Comprehensive Literature Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7488-1975","authenticated-orcid":false,"given":"Antonio","family":"Podo Brunetti","sequence":"first","affiliation":[{"name":"Unit of Clinic Dermatology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7010-8255","authenticated-orcid":false,"given":"Gianmarco Diego","family":"Bigotto","sequence":"additional","affiliation":[{"name":"Unit of Clinic Dermatology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Stabile","sequence":"additional","affiliation":[{"name":"Unit of Clinic Dermatology, Vita-Salute San Raffaele University, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5986-6392","authenticated-orcid":false,"given":"Valentina","family":"Caputo","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology, ASST Grande Ospedale Metropolitano Niguarda, 20162 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Brambilla","sequence":"additional","affiliation":[{"name":"Unit of Dermatology, Foundation IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Guida","sequence":"additional","affiliation":[{"name":"Unit of Clinic Dermatology, Vita-Salute San Raffaele University, 20132 Milan, Italy"},{"name":"Unit of Clinic Dermatology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Rongioletti","sequence":"additional","affiliation":[{"name":"Unit of Clinic Dermatology, Vita-Salute San Raffaele University, 20132 Milan, Italy"},{"name":"Unit of Clinic Dermatology, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"20713","DOI":"10.5070\/D31912020713","article-title":"Lichen planus pigmentosus","volume":"19","author":"Rieder","year":"2013","journal-title":"Dermatol. 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Dermatopathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.jdcr.2018.02.008","article-title":"Pigmented actinic lichen planus (PALP) mimicking lentigo maligna melanoma: Usefulness of in vivo reflectance confocal microscopy in diagnosis and follow-up","volume":"4","author":"Venturini","year":"2018","journal-title":"JAAD Case Rep."},{"key":"ref_5","first-page":"725","article-title":"Gingival melanoacanthoma associated with pseudomelanocytic nests: Expanding the clinicopathological spectrum of a recently described oral lesion","volume":"45","author":"Macedo","year":"2012","journal-title":"J. Cutan. 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Dermatopathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/cup.12455","article-title":"Soluble adenylyl cyclase (sAC) immunostaining distinguishes pseudomelanocytic nests in lichenoid tissue reaction","volume":"42","author":"Hall","year":"2015","journal-title":"J. Cutan. Pathol."},{"key":"ref_16","first-page":"116","article-title":"Report of two cases of vacuolar interface dermatitis initially suspected as melanomain situand review of the literature","volume":"52","author":"Torres","year":"2016","journal-title":"J. Bras. Patol. Med. Lab."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/DAD.0000000000001847","article-title":"Oral Lichen Planus Associated with Lichen Planus Pigmentosus and Lichen Sclerosus in Monozygotic Twins","volume":"43","author":"Marques","year":"2021","journal-title":"Am. J. Dermatopathol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/10\/3\/36\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:47:11Z","timestamp":1760129231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/10\/3\/36"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,8]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["dermatopathology10030036"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology10030036","relation":{},"ISSN":["2296-3529"],"issn-type":[{"type":"electronic","value":"2296-3529"}],"subject":[],"published":{"date-parts":[[2023,9,8]]}}}