{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T19:10:50Z","timestamp":1792955450180,"version":"4.5.0"},"reference-count":16,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>The intratarsal keratinous cyst (IKC) is a recently described entity, often clinically misdiagnosed as a chalazion. We report a case of a 61-year-old male patient with a chief complaint of a small lesion on the upper eyelid that evolved over six months. On physical examination, an asymptomatic, firm nodule was identified on the left upper eyelid. The patient reported no history of trauma. A provisional diagnosis of chalazion was established, and an excisional biopsy was performed. Histopathologically, the lesion was lined with a stratified squamous epithelium, with a corrugated epithelial surface showing abrupt keratinization without keratohyalin granules, and compact keratinous-appearing material in the cystic lumen. The diagnosis was IKC. No signs of recurrence were observed after one year of follow-up. It is essential to accurately diagnose IKC and distinguish it from chalazion and epidermal inclusion cysts, because IKC requires complete surgical excision and can exhibit multiple recurrences if not properly removed.<\/jats:p>","DOI":"10.3390\/dermatopathology11020014","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T08:44:31Z","timestamp":1713516271000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intratarsal Keratinous Cyst Clinically Misdiagnosed as a Chalazion"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0679-8485","authenticated-orcid":false,"given":"John Lennon Silva","family":"Cunha","sequence":"first","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Dentistry, State University of Para\u00edba (UEPB), Campina Grande 58429-600, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clenia E. S.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Residency Program in Oral and Maxillofacial Surgery, School of Public Health of Para\u00edba, Jo\u00e3o Pessoa 58040-440, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A. P.","family":"da Cunha Filho","sequence":"additional","affiliation":[{"name":"Residency Program in Oral and Maxillofacial Surgery, School of Public Health of Para\u00edba, Jo\u00e3o Pessoa 58040-440, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre R.","family":"da Paz","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathology, Federal University of Para\u00edba (UFPB), Jo\u00e3o Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7039-4004","authenticated-orcid":false,"given":"Manuel A.","family":"Gord\u00f3n-N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Dentistry, State University of Para\u00edba (UEPB), Campina Grande 58429-600, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-4032","authenticated-orcid":false,"given":"Pollianna M.","family":"Alves","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Dentistry, State University of Para\u00edba (UEPB), Campina Grande 58429-600, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2380-109X","authenticated-orcid":false,"given":"Cassiano F. W.","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Dentistry, Department of Dentistry, State University of Para\u00edba (UEPB), Campina Grande 58429-600, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ajo.2009.07.033","article-title":"Intratarsal Keratinous Cysts of the Meibomian Gland: Distinctive Clinicopathologic and Immunohistochemical Features in 6 Cases","volume":"149","author":"Jakobiec","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000501369","article-title":"Complex Intratarsal Cyst with a Mixed Ciliated Respiratory-Type and Squamous Epithelial Lining","volume":"6","author":"Jakobiec","year":"2020","journal-title":"Ocul. Oncol. 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