{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T21:06:35Z","timestamp":1787951195454,"version":"build-2784847793"},"reference-count":49,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T00:00:00Z","timestamp":1718323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Primary Cutaneous Lymphomas in Croatia","award":["214-2180056-0052"],"award-info":[{"award-number":["214-2180056-0052"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Primary cutaneous lymphomas (PCLs), especially mycosis fungoides (MF), pose significant diagnostic and therapeutic challenges. This study aims to correlate initial histological features with the disease course and survival in MF patients. A retrospective\u2013prospective cohort study was conducted on 83 patients diagnosed with early-stage MF at the Departments of Dermatovenerology and Pathology, UHC Zagreb, from January 2003 to December 2012. The analyzed histopathological parameters included lichenoid dermal lymphocyte infiltrate, Pautrier microabscesses, and lymphocyte atypia. Patients with more than 30 guardian lymphocytes per 100 keratinocytes exhibited worse overall and progression-free survival. Furthermore, those with over 50% atypical lymphocytes demonstrated a faster progression rate. A dense lichenoid dermal infiltrate and a high count of lymphocyte \u201ckeepers\u201d significantly increased the mortality risk within five years of diagnosis. This study did not fully confirm the hypothesis regarding the prognostic value of large Pautrier microabscesses but highlighted the importance of dense lichenoid infiltrates. The study identified new potential histopathological prognostic factors in early-stage MF, suggesting the need for larger studies to confirm these findings. The identification of such predictors could enhance the prognostic stratification and guide more tailored therapeutic approaches for MF patients.<\/jats:p>","DOI":"10.3390\/dermatopathology11020017","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T12:48:40Z","timestamp":1718628520000},"page":"161-176","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Prognostic Value of Histopathological Features in Early-Stage Mycosis Fungoides: Insights from a Retrospective\u2013Prospective Cohort Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1051-043X","authenticated-orcid":false,"given":"Sandra","family":"Jerkovic Gulin","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology, Ryhov County Hospital, 551 85 Jonkoping, Sweden"},{"name":"Department of Biomedical and Clinical Sciences, Faculty of Medicine and Health Sciences, Linkoping University, 581 85 Linkoping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Ilic","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cytology, University Hospital Centre Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romana","family":"Ceovic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology, School of Medicine, University of Zagreb, University Hospital Centre Zagreb, 10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"Willemze","year":"2005","journal-title":"Blood"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"113343","DOI":"10.1016\/j.ejca.2023.113343","article-title":"EORTC consensus recommendations for the treatment of mycosis fungoides\/S\u00e9zary syndrome\u2014Update 2023","volume":"195","author":"Latzka","year":"2023","journal-title":"Eur. 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