{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:59:37Z","timestamp":1774583977668,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T00:00:00Z","timestamp":1731974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Dermatology Association of Radiation Therapy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Non-melanoma skin cancers (NMSCs), including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), are highly prevalent and a significant cause of morbidity. Image-guided superficial radiation therapy (IGSRT) uses integrated high-resolution dermal ultrasound to improve lesion visualization, but it is unknown whether efficacy varies by histology. This large retrospective cohort study was conducted to determine the effect of tumor histology on freedom from recurrence in 20,069 biopsy-proven NMSC lesions treated with IGSRT, including 9928 BCCs (49.5%), 5294 SCCs (26.4%), 4648 SCCIS cases (23.2%), and 199 lesions with \u22652 NMSCs (1.0%). Freedom from recurrence at 2, 4, and 6 years was 99.60%, 99.45%, and 99.45% in BCC; 99.58%, 99.49%, and 99.49% in SCC; and 99.96%, 99.80%, and 99.80% in SCCIS. Freedom from recurrence at 2, 4, and 6 years following IGSRT did not differ significantly comparing BCC vs. non-BCC or SCC vs. non-SCC but were slightly lower among SCCIS vs. non-SCCIS (p = 0.002). There were no significant differences in freedom from recurrence when stratifying lesions by histologic subtype. This study demonstrates that there is no significant effect of histology on freedom from recurrence in IGSRT-treated NMSC except in SCCIS. These findings support IGSRT as a first-line therapeutic option for NMSC regardless of histology.<\/jats:p>","DOI":"10.3390\/dermatopathology11040033","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T09:14:38Z","timestamp":1732094078000},"page":"315-329","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Image-Guided Radiation Therapy Is Equally Effective for Basal and Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6604-1273","authenticated-orcid":false,"given":"Erin M.","family":"McClure","sequence":"first","affiliation":[{"name":"University Hospitals Geauga Medical Center, University Hospitals Regional Hospitals, Chardon, OH 44024, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clay J.","family":"Cockerell","sequence":"additional","affiliation":[{"name":"Dermatology Residency Program, Dallas-Fort Worth\/Lake Granbury, Granbury, TX 76048, USA"},{"name":"Cockerell Dermatopathology, Dallas, TX 75235, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Hammond","sequence":"additional","affiliation":[{"name":"Polaris Skin and Tissue Diagnostics, Myrtle Beach, SC 29572, USA"},{"name":"Waccamaw Dermatology, Bypass, Suite 200, Myrtle Beach, SC 29588, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyn S.","family":"Marienberg","sequence":"additional","affiliation":[{"name":"Laserderm Dermatology, Smithtown, NY 11787, USA"},{"name":"Summit Health\/City MD, Rye, NY 10580, USA"},{"name":"New York Radiation Oncology Associates, Jamaica, NY 11435, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobby N.","family":"Koneru","sequence":"additional","affiliation":[{"name":"FHN Leonard C. Ferguson Cancer Center, Freeport, IL 61032, USA"},{"name":"Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA"},{"name":"Paramount Oncology Group, Dubuque, IA 52001, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Ward","sequence":"additional","affiliation":[{"name":"Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA"},{"name":"Dermatology Solutions Group, Panama City, FL 32405, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey B.","family":"Stricker","sequence":"additional","affiliation":[{"name":"Alabama College of Osteopathic Medicine, Dothan, AL 36303, USA"},{"name":"Dermatology Specialists of Alabama, Dothan, Dothan, AL 36303, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cives, M., Mannavola, F., Lospalluti, L., Sergi, M.C., Cazzato, G., Filoni, E., Cavallo, F., Giudice, G., Stucci, L.S., and Porta, C. 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