{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T05:48:41Z","timestamp":1783057721105,"version":"3.54.6"},"reference-count":71,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Kikuchi\u2013Fujimoto disease (KFD) is a rare condition characterized by necrotizing lymphadenitis and fever, often associated with immune dysregulation. Histologically, it features necrotic foci with abundant histiocytes and plasmacytoid dendritic cells but notably lacks neutrophils and eosinophils. Recent evidence reveals a notable prevalence among pediatric patients, who may exhibit distinct features compared to adults. We reported the case of an 11-year-old girl presenting with persistent fever, cervical adenopathy, and a malar rash, leading to a diagnosis of KFD following lymph node biopsy, which revealed non-suppurative necrosis and histiocytic infiltration. Empirical treatment with antivirals and antibiotics was ineffective, but corticosteroid therapy achieved symptom remission. A literature review identified 48 relevant studies involving 386 pediatric cases, with histopathological findings consistent with classical descriptions of KFD. Cutaneous involvement was reported in 11.14% of cases, ranging from maculopapular rashes to lupus-like eruptions. Notable complications included the development of systemic lupus erythematous, Sj\u00f6gren syndrome, and rare instances of hemophagocytic syndrome or central nervous system involvement. Kikuchi\u2013Fujimoto disease should be considered in the differential diagnosis of pediatric patients presenting with fever and lymphadenopathy, taking into account a higher frequency of cutaneous manifestations in pediatric cases. A skin biopsy may be helpful in diagnosing KFD and provide valuable information regarding the potential risk of developing systemic lupus erythematosus in the future.<\/jats:p>","DOI":"10.3390\/dermatopathology12010007","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:01:19Z","timestamp":1739433679000},"page":"7","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pediatric Kikuchi\u2013Fujimoto Disease: Case Report and Review of Cutaneous and Histopathologic Features in Childhood"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5040-8483","authenticated-orcid":false,"given":"Alberto","family":"Soto-Moreno","sequence":"first","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-2741","authenticated-orcid":false,"given":"Francisco","family":"V\u00edlchez-M\u00e1rquez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Narv\u00e1ez-Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Pathology Derpartment, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Castro-Mart\u00edn","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8829-7251","authenticated-orcid":false,"given":"Francisco Manuel","family":"Ramos-Pleguezuelos","sequence":"additional","affiliation":[{"name":"Pathology Derpartment, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Soto-D\u00edaz","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-594X","authenticated-orcid":false,"given":"Jes\u00fas","family":"Tercedor-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1435","authenticated-orcid":false,"given":"Salvador","family":"Arias-Santiago","sequence":"additional","affiliation":[{"name":"Dermatology Department, Hospital Universitario Virgen de Las Nieves, 18012 Granada, Spain"},{"name":"Granada Institute for Biosanitary Research, 18012 Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.5858\/arpa.2018-0219-RA","article-title":"Kikuchi-Fujimoto Disease: A Review","volume":"142","author":"Perry","year":"2018","journal-title":"Arch. 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