{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T12:21:49Z","timestamp":1774009309629,"version":"3.50.1"},"reference-count":12,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Granular cell tumors are uncommon neoplasms of neural origin that may involve the skin and often present with nonspecific clinical features, making diagnosis challenging. Cutaneous granular cell tumors rarely exhibit overlying hypertrichosis, a finding that may obscure their clinical recognition. In this report, we describe a rare case of a primary cutaneous granular cell tumor with prominent overlying terminal hair growth in an adult patient. A 27-year-old woman presented with a slowly enlarging, firm, pigmented plaque on the upper back associated with pruritus and increased hair growth. Histopathologic examination revealed sheets of large polygonal cells with abundant granular eosinophilic cytoplasm, and immunohistochemical staining was positive for S100, SOX10, CD68, and calretinin, confirming the diagnosis. The lesion was completely excised with no evidence of malignancy. To our knowledge, this represents the second reported instance of a cutaneous granular cell tumor associated with hypertrichosis and the first described in an adult. It underscores the importance of clinicopathologic correlation in evaluating unusual cutaneous lesions and expands the spectrum of recognized presentations of cutaneous granular cell tumors.<\/jats:p>","DOI":"10.3390\/dermatopathology13010011","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T09:44:41Z","timestamp":1773999881000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Granular Cell Tumor with Overlying Hypertrichosis in an Adult: A Rare Case Report"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1153-4733","authenticated-orcid":false,"given":"Yara","family":"Alhusaini","sequence":"first","affiliation":[{"name":"Department of Dermatology, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulaziz","family":"Almufadhi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naif","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9471-615X","authenticated-orcid":false,"given":"Nawaf","family":"Alqahtani","sequence":"additional","affiliation":[{"name":"Department of Dermatology, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohoud","family":"Aljarbou","sequence":"additional","affiliation":[{"name":"Department of Pathology, King Abdulaziz Medical City, Riyadh 11426, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.4103\/jfmpc.jfmpc_642_22","article-title":"Cutaneous granular cell tumor: A case series, review, and update","volume":"11","author":"Fahim","year":"2022","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.12688\/f1000research.13015.1","article-title":"Case report: Cutaneous granular cell tumors","volume":"7","author":"Montazer","year":"2018","journal-title":"F1000Research"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13000-015-0357-2","article-title":"Primary cutaneous malignant granular cell tumor: A case report and literature review","volume":"10","author":"Liu","year":"2015","journal-title":"Diagn. Pathol."},{"key":"ref_4","first-page":"218","article-title":"Cutaneous Granular Cell Tumor in a Middle-aged Woman: Clinicopathological Insights from a Rare Schwannian Neoplasm","volume":"16","author":"Palo","year":"2025","journal-title":"J. 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Dermatol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T10:25:50Z","timestamp":1774002350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,20]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["dermatopathology13010011"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology13010011","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,20]]}}}