{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:28:54Z","timestamp":1781152134295,"version":"3.54.1"},"reference-count":31,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Biopsies are only performed in less than 1% of all consultations dedicated to paediatric genital dermatology. The objectives of this paper are to review and clarify the histopathological features of the conditions most often biopsied: first, lichen sclerosus, which has a peak incidence in childhood and progresses over years; secondly, pigmented lesions, including atypical genital naevi and common naevi in the context of lichen sclerosus, both histologically differential diagnoses of melanoma, which probably does not present in childhood. And finally, Crohn\u2019s disease, which is a cause of vulval oedema or genital ulceration.<\/jats:p>","DOI":"10.3390\/dermatopathology13010012","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:59:36Z","timestamp":1774267176000},"page":"12","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Genital Disorders in Children: What Does a Biopsy Bring?"],"prefix":"10.3390","volume":"13","author":[{"given":"Francoise","family":"Plantier","sequence":"first","affiliation":[{"name":"Department of Pathology, H\u00f4pital Cochin, AP-HP Centre-Universit\u00e9 de Paris, 27 rue du Faubourg Saint-Jacques, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-1518","authenticated-orcid":false,"given":"Fiona","family":"Lewis","sequence":"additional","affiliation":[{"name":"St John\u2019s Institute of Dermatology, Guy\u2019s & St Thomas\u2019 NHS Trust, London SE1 7EH, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1525-1470.2000.01701.x","article-title":"Vulvar disease in children: A clinical audit of 130 cases","volume":"17","author":"Fischer","year":"2000","journal-title":"Pediatr. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Jerkovic Gulin, S., Lundin, F., Eriksson, O., and Seifert, O. (2024). Lichen sclerosus-Incidence and comorbidity: A nationwide Swedish register study?. J. Clin. Med., 13.","DOI":"10.3390\/jcm13102761"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0190-9622(99)70247-1","article-title":"Incidence of preputial lichen sclerosus in adults: Histologic study of circumcision specimens","volume":"41","author":"Aynaud","year":"1999","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","first-page":"134","article-title":"Pathological Investigation of Childhood Foreskin: Are Lichen Sclerosus and Phimosis Common?","volume":"26","author":"Irkilata","year":"2016","journal-title":"J. Coll. Physicians Surg. Pak."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1007\/s00431-017-3004-y","article-title":"Genital lichen sclerosus in childhood and adolescence-a retrospective case series of 15 patients: Early diagnosis is crucial to avoid long-term sequelae","volume":"176","author":"Nerantzoulis","year":"2017","journal-title":"Eur. J. Pediatr."},{"key":"ref_6","first-page":"49","article-title":"Pediatric Lichen Sclerosus: A Review of the Literature and Management","volume":"9","author":"Dinh","year":"2016","journal-title":"J. Clin. Aesthet. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/pde.14967","article-title":"Comparison of lichen sclerosus in boys and girls: A systematic review of epidemiology, symptoms, genetic background, risk factors, and prognosis","volume":"39","author":"Kumar","year":"2022","journal-title":"Pediatr. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/DAD.0000000000001248","article-title":"Childhood phimosis secondary to lichen sclerosus: Is there a spatial pattern of histopathological changes?","volume":"40","author":"Singh","year":"2018","journal-title":"Am. J. Dermatopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/pde.14771","article-title":"Vulvar vitiligo and lichen sclerosus in children: A clinical challenge","volume":"38","author":"Veronesi","year":"2021","journal-title":"Pediatr. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.humpath.2020.09.003","article-title":"Structured analysis of histopatholgical characteristics of vulvar lichen sclerosus in a juvenile population","volume":"106","author":"Morrel","year":"2020","journal-title":"Hum. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1525-1470.2005.22404.x","article-title":"High incidence of balanitis xerotica obliterans in boys with phimosis: A prospective 10-year study","volume":"22","author":"Kiss","year":"2005","journal-title":"Pediatr. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jdcr.2021.05.017","article-title":"Juvenile and adult vulval pemphigoid, an under recognized entity: Case series of fourteen patients","volume":"13","author":"Rashid","year":"2021","journal-title":"JAAD Case Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1158\/1055-9965.EPI-16-0019","article-title":"Lichen sclerosus: Incidence and risk of vulvar squamous cell carcinoma","volume":"25","author":"Bleeker","year":"2016","journal-title":"Cancer Epidemiol. Biomark."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaad.2013.10.022","article-title":"Genital melanocytic nevi in children: Experience in a pediatric dermatology practice","volume":"70","author":"Hunt","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5858\/2009-0382-RA.1","article-title":"Atypical genital nevus","volume":"135","author":"Brenn","year":"2011","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"100140","DOI":"10.1016\/j.xjidi.2022.100140","article-title":"A scoping review and population study regarding prevalence and histopathology of juvenile vulvar melanocytic lesions. A recommendation","volume":"2","author":"Morrel","year":"2022","journal-title":"JID Innov."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0046-8177(98)80028-2","article-title":"Atypical melanocytic nevi of the genital type with a discussion od reciprocal parenchymal-stromal interactions in the biology of neoplasia","volume":"29","author":"Clark","year":"1998","journal-title":"Hum. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1001\/archderm.138.1.77","article-title":"Melanocytic proliferations associated with lichen sclerosus","volume":"138","author":"Carlson","year":"2002","journal-title":"Arch. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1007\/s00404-009-1049-5","article-title":"Melanocytic proliferations associated with lichen sclerosus in adolescence","volume":"280","author":"Bussen","year":"2009","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jaad.2003.09.034","article-title":"Genital lentigines and melanocytic nevi with superimposed lichen sclerosus: A diagnostic challenge","volume":"50","author":"Soyer","year":"2004","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/08880018.2025.2466023","article-title":"Temporal trends and unbalanced distribution, in pediatric cutaneous melanoma in 204 countries and territories, 1990\u20132019","volume":"42","author":"Faderani","year":"2025","journal-title":"Pediatr. Hematol. Oncol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jpeds.2015.02.050","article-title":"Melanoma incidence in children and adolescents: Decreasing trends in the United states","volume":"166","author":"Campbell","year":"2015","journal-title":"J. Pediatr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.jaad.2024.10.084","article-title":"Clinical presentations and decreasing incidence of melanoma in pediatric and adolescent and young adult patients: 76,108 cases from a nationally representative cohort","volume":"92","author":"Ituarte","year":"2025","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"115079","DOI":"10.1016\/j.ejca.2024.115079","article-title":"Incidence and prognosis of cutaneous melanoma in European adolescents and young adults (AYAs): EUROCARE-6 retrospective cohort results","volume":"213","author":"Indini","year":"2024","journal-title":"Eur. J. Cancer"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Hatheway Marshall, E., Alvarez, G., Wang, B., Crimmins, J., Schneider, M.M., Selim, M.A., and Al-Rohil, R. (2023). Pediatric atypical melanocytic proliferations: Single-site retrospective cohort assessment of treatment and long-term follow-up. Cancer, 12.","DOI":"10.3390\/cancers15245804"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Lee, D.H., Kim, M.J., Lee, I.J., and Park, D.H. (2020). Transformation of malignant melanoma from giant nevus in infantile penis. Front. Surg., 22.","DOI":"10.3389\/fsurg.2020.594803"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/j.jaad.2005.07.034","article-title":"Vulvar melanoma in a 10-year-old girl in association with lichen sclerusus","volume":"54","author":"Rosamilia","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"166.e7","DOI":"10.1016\/j.urolonc.2015.11.009","article-title":"Primary genitourinary melanoma: Epidemiology and disease specific survival in a large population-based cohort","volume":"34","author":"Sanchez","year":"2016","journal-title":"Urol. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1525-1470.2010.01138.x","article-title":"Cutaneous Crohn\u2019s disease in the pediatric population","volume":"27","author":"Vaid","year":"2010","journal-title":"Pediatr. Dermatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/archdischild-2016-311806","article-title":"Vulvar inflammation: A presentation of Crohn\u2019s disease","volume":"102","author":"Ferreira","year":"2017","journal-title":"Arch. Dis. Child."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/DAD.0000000000001543","article-title":"Metastatic Crohn Disease: A Clinicohistological Appraisal from a Tertiary Care Center in India","volume":"42","author":"Chatterjee","year":"2020","journal-title":"Am. J. Dermatopathol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/1\/12\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:42:21Z","timestamp":1774269741000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/1\/12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,23]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["dermatopathology13010012"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology13010012","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,23]]}}}