{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:17:20Z","timestamp":1777695440176,"version":"3.51.4"},"reference-count":11,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Granuloma annulare is a non-infectious granulomatous dermatosis with a probable pathogenic mechanism of delayed-type hypersensitivity, in which the dermal histiocytic granulomatous infiltrate is usually accompanied by a lesser component of lymphocytes. Although there are more common clinical and histopathological patterns of presentation, there are less well-known variants that may pose significant diagnostic challenges by mimicking other inflammatory cutaneous processes or even neoplastic conditions. One of the rarest forms of granuloma annulare is the pseudolymphomatous variant, in which the lymphocytic component is not only highly prominent but may, in some cases, partially or completely obscure the histiocytic component itself. This feature, together with the fact that the clinical presentation of this variant is often atypical\u2014frequently lacking the characteristic annular morphology of conventional granuloma annulare\u2014renders the diagnosis particularly challenging. From an immunohistochemical standpoint, the infiltrates described are predominantly composed of T cells, with only a sparse and scattered B-cell component. In this article, we present a case of granuloma annulare with a pseudolymphomatous B-cell component (PAX5+, CD79+) and minimal T-cell involvement, observed in a 4 mm skin nodule located on the shoulder of a 48-year-old male. This case therefore broadens the concept of pseudolymphomatous granuloma annulare to include infiltrates predominantly composed of B lymphocytes.<\/jats:p>","DOI":"10.3390\/dermatopathology13020019","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:43:51Z","timestamp":1777448631000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pseudolymphomatous Granuloma Annulare Rich in B Lymphocytes"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-2364","authenticated-orcid":false,"given":"Angel","family":"Fernandez-Flores","sequence":"first","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica, Hospital El Bierzo, M\u00e9dicos sin Fronteras 7, 24411 Ponferrada, Spain"},{"name":"Department of Cellular Pathology, Hospital de la Reina, 24400 Ponferrada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Mart\u00ednez-Amo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University Hospital Poniente, 04700 Almeria, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/dermatopathology7020006","article-title":"Pseudolymphomatous Granuloma Annulare: A Case Report","volume":"7","author":"Ibrahim","year":"2020","journal-title":"Dermatopathology"},{"key":"ref_2","first-page":"162","article-title":"Pseudolymphomatous Granuloma Annulare: A Little-Known Variant","volume":"110","author":"Fraga","year":"2019","journal-title":"Actas Dermo-Sifiliogr."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/DAD.0b013e31822a2aca","article-title":"Granuloma Annulare With Prominent Lymphoid Infiltrates (\u201cPseudolymphomatous\u201d Granuloma Annulare)","volume":"34","author":"Cota","year":"2012","journal-title":"Am. 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Oswaldo Cruz"},{"key":"ref_10","first-page":"51","article-title":"Messy granuloma: An additional pattern of granulomatous reaction","volume":"57","year":"2016","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jaad.2015.09.038","article-title":"Morphological and immunohistochemical clues for the diagnosis of cutaneous leishmaniasis and the interpretation of CD1a status","volume":"74","year":"2016","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/2\/19\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T09:17:32Z","timestamp":1777454252000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/13\/2\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,6]]}},"alternative-id":["dermatopathology13020019"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology13020019","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}