{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:17:49Z","timestamp":1785410269613,"version":"3.56.0"},"reference-count":52,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cVictor Babes\u201d University of Medicine and Pharmacy Timi\u0219oara"},{"id":[{"id":"https:\/\/ror.org\/00afdp487","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Aim: This study aimed to identify the clinical and pathological features of primary cutaneous melanomas in young patients, comparing them with those of older patients. Materials and Methods: We performed a retrospective study observing the differences with respect to clinical and pathological features in young patients versus older patients. We distributed the cases into two groups: patients &lt; 40 years diagnosed with cutaneous melanoma and patients \u2265 40 years diagnosed with cutaneous melanoma. Results: From the total number of primary cutaneous melanomas diagnosed, 11% of cases were represented by young patients. The clinical and pathological features more frequently associated with cutaneous melanomas in AYAs (adolescents and young adults) were represented by the superficial spreading subtype (p = 0.0003), a brisk inflammatory infiltrate (p = 0.0061), a pT1\u2013pT2 pathological stage (p = 0.0183), decreased mitotic activity (p = 0.0186), decreased Breslow index (p = 0.0301), and female sex (p = 0.022). Conclusions: The most important features of cutaneous melanomas diagnosed in AYA patients were represented by the superficial spreading subtype, the presence of a brisk inflammatory infiltrate, and a pT1\u2013pT2 pathological stage.<\/jats:p>","DOI":"10.3390\/dermatopathology13020027","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T18:35:05Z","timestamp":1782239705000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cutaneous Melanoma in Adolescents and Young Adults Versus Older Patients: Clinical and Histopathological Differences in Western Romania"],"prefix":"10.3390","volume":"13","author":[{"given":"Bianca Roxana","family":"Natar\u00e2\u015f","sequence":"first","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3971-2756","authenticated-orcid":false,"given":"Sorina Maria","family":"T\u0103ban","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0898-795X","authenticated-orcid":false,"given":"Aura","family":"Jurescu","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8259-9437","authenticated-orcid":false,"given":"Octavia Cornelia","family":"Vi\u0163a","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remus Florin","family":"Cornea","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana","family":"Hurmuz","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7072-6083","authenticated-orcid":false,"given":"Adelina","family":"Vidac","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daciana","family":"Grujic","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4453-2792","authenticated-orcid":false,"given":"Valentin Tudor","family":"Popa","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"},{"name":"Doctoral School, \u201cVictor Babe\u015f\u201d University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alis Liliana Carmen","family":"Dema","sequence":"additional","affiliation":[{"name":"Anapatmol Research Centre, Victor Babe\u015f University of Medicine and Pharmacy, 300041 Timi\u015foara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,6,20]]},"reference":[{"key":"ref_1","unstructured":"Adolescent and Young Adult Oncology Progress Review Group (2006). 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