{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T08:25:40Z","timestamp":1788251140383,"version":"build-2803163510"},"reference-count":53,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,5,21]],"date-time":"2021-05-21T00:00:00Z","timestamp":1621555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>The interface dermatitides encompass a vast array of cutaneous entities which, at times, may present with particular clinical variants with adnexal predilection. Similarly, hair follicle and eccrine gland involvement of some of these entities has been observed on histopathology. This review aims to describe the various adnexotropic presentations of the interface dermatitides. Recognizing that the adnexa can be a frequent site of involvement of these conditions may aid dermatopathologists in making the correct diagnosis and avoid misinterpreting adnexotropism for other conditions such as the great imitator, mycosis fungoides.<\/jats:p>","DOI":"10.3390\/dermatopathology8020020","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T02:32:43Z","timestamp":1621823563000},"page":"135-146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adnexotropic Variants of the Interface Dermatitides: A Review"],"prefix":"10.3390","volume":"8","author":[{"given":"Carla","family":"Stephan","sequence":"first","affiliation":[{"name":"Department of Dermatology, American University of Beirut, Beirut 11-0236, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6970-8056","authenticated-orcid":false,"given":"Ossama","family":"Abbas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, American University of Beirut, Beirut 11-0236, Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9264-7300","authenticated-orcid":false,"given":"Jag","family":"Bhawan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Boston University School of Medicine, Boston, MA 02118-2415, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"652","DOI":"10.5858\/2008-132-652-ID","article-title":"Interface dermatitis","volume":"132","author":"Crowson","year":"2008","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4103\/0378-6323.82389","article-title":"Lichenoid tissue reaction\/interface dermatitis: Recognition, classification, etiology, and clinicopathological overtones","volume":"77","author":"Sehgal","year":"2011","journal-title":"Indian J. Derm. Venereol. Leprol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/cup.13724","article-title":"Lichen planus follicularis tumidus: Immunotyping of the inflammatory infiltrate with focus on plasmacytoid dendritic cells","volume":"47","author":"Saggini","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1111\/cup.12181","article-title":"Facial follicular cysts: A case of lichen planus follicularis tumidus?","volume":"40","year":"2013","journal-title":"J. Cutan. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1111\/jdv.13454","article-title":"Lichen planus pigmentosus: A retrospective clinico-epidemiologic study with emphasis on the rare follicular variant","volume":"30","author":"Sindhura","year":"2016","journal-title":"J. Eur. Acad. Derm. Venereol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"346","DOI":"10.2340\/0001555567346350","article-title":"Acrosyringeal lichen planus","volume":"67","author":"Enhamre","year":"1987","journal-title":"Acta Derm. Venereol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1097\/DAD.0000000000001295","article-title":"Syringotropic lichen planus: A potential histopathologic mimicker of syringotropic mycosis fungoides","volume":"41","author":"Mazzeo","year":"2019","journal-title":"Am. J. Derm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.4103\/0378-6323.98106","article-title":"Acrosyringeal lichen planus of palm","volume":"78","author":"Gutte","year":"2012","journal-title":"Indian J. Derm. Venereol. Leprol."},{"key":"ref_9","first-page":"350","article-title":"Unilateral acrosyringeal lichen planus of palm","volume":"4","author":"Gutte","year":"2013","journal-title":"Indian J. Derm. Venereol. Leprol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00403-018-1882-0","article-title":"Leakage of sweat into the dermo-epidermal junction as a possible trigger for lichen planus lesion development","volume":"311","author":"Mizukawa","year":"2019","journal-title":"Arch. Derm. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000496446","article-title":"Acute hair loss 3 Years after bone marrow transplant","volume":"5","author":"Silva","year":"2019","journal-title":"Skin Appendage Disord."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4103\/ijd.IJD_412_18","article-title":"Follicular graft-versus-host disease: A rare manifestation in a patient with the overlap subtype of chronic graft-versus-host disease","volume":"64","author":"Ho","year":"2019","journal-title":"Indian J. Derm."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/DAD.0b013e3181855701","article-title":"Follicular graft-versus-host disease: A rare manifestation of chronic cutaneous graft-versus-host disease","volume":"30","author":"Martin","year":"2008","journal-title":"Am. J. Derm."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/000155598443178","article-title":"A follicular lichenoid eruption as manifestation of chronic graft-vs-host disease","volume":"78","author":"Valks","year":"1998","journal-title":"Acta Derm. Venereol."},{"key":"ref_15","first-page":"223","article-title":"Parafollicular hair bulge in human GVHD: A stem cell-rich primary target","volume":"11","author":"Sale","year":"1993","journal-title":"Bone Marrow Transpl."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbmt.2005.10.023","article-title":"Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report","volume":"12","author":"Shulman","year":"2006","journal-title":"Biol. Blood Marrow Transpl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2340\/00015555-1787","article-title":"Coexistence of eccrine squamous syringometaplasia and graft-versus-host disease in a patient with secondary myelodysplastic syndrome","volume":"94","author":"Carrascosa","year":"2014","journal-title":"Acta Derm. Venereol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.5021\/ad.2014.26.4.505","article-title":"Three cases of lichen nitidus associated with various cutaneous diseases","volume":"26","author":"Cho","year":"2014","journal-title":"Ann. Derm."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1034\/j.1600-0560.2002.290211.x","article-title":"Periappendageal lichen nitidus: Report of a case","volume":"292","author":"Sanders","year":"2002","journal-title":"J. Cutan. Pathol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1600-0560.1988.tb00553.x","article-title":"Spinous, follicular lichen nitidus associated with perifollicular granulomas","volume":"15","author":"Madhok","year":"1988","journal-title":"J. Cutan. Pathol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/cup.13712","article-title":"An unusual variant of lichen nitidus: Generalized follicular spinous with perifollicular granulomas","volume":"47","author":"Taneja","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_22","first-page":"e20","article-title":"Generalized spinous follicular lichen nitidus with perifollicular granulomas","volume":"30","author":"Summe","year":"2013","journal-title":"Pediatr. Derm."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/DAD.0000000000000661","article-title":"Folliculocentric Lichen Sclerosus et Atrophicus in a 10-Year-Old Girl","volume":"39","author":"Mannava","year":"2017","journal-title":"Am. J. Derm."},{"key":"ref_24","first-page":"242","article-title":"Folliculocentric lichen sclerosus et atrophicus","volume":"8","author":"Mann","year":"2010","journal-title":"Skinmed"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1111\/cup.13776","article-title":"Acrosyringeal variant of extragenital lichen sclerosus et atrophicus","volume":"47","author":"Lee","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1097\/DAD.0000000000000077","article-title":"Striking follicular eruption to pegylated liposomal doxorubicin","volume":"36","author":"Dai","year":"2014","journal-title":"Am. J. Derm."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4103\/0378-6323.206233","article-title":"Pegylated liposomal doxorubicin-induced miliaria crystallina and lichenoid follicular eruption","volume":"84","author":"Seghers","year":"2018","journal-title":"Indian J. Derm. Venereol. Leprol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1097\/DAD.0b013e3182919e3a","article-title":"Lichenoid eruption associated with antituberculous drug; an unusual oral and follicular involvement","volume":"36","author":"Byun","year":"2014","journal-title":"Am. J. Derm."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/CMR.0000000000000518","article-title":"Cutaneous adverse events of anti-programmed death 1 antibodies combined with anti-cytotoxic T-lymphocyte-associated protein 4 therapy use in patients with metastatic melanoma","volume":"29","author":"Hwang","year":"2019","journal-title":"Melanoma. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/DAD.0000000000000587","article-title":"Histologic assessment of lichenoid dermatitis observed in patients with advanced malignancies on antiprogramed cell Death-1 (anti-PD-1) therapy with or without ipilimumab","volume":"39","author":"Chou","year":"2017","journal-title":"Am. J. Dermatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000437383","article-title":"Unique cutaneous reaction to second- and third-generation tyrosine kinase inhibitors for chronic myeloid leukemia","volume":"232","author":"Patel","year":"2016","journal-title":"Dermatology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1590\/abd1806-4841.20164724","article-title":"Lichen planopilaris-like eruption during treatment with tyrosine kinase inhibitor nilotinib","volume":"91","author":"Valente","year":"2016","journal-title":"An. Bras. Dermatol."},{"key":"ref_33","first-page":"216","article-title":"Cutaneous lupus erythematosus: Clinico-pathologic correlation","volume":"153","author":"Filotico","year":"2018","journal-title":"G. Ital. Derm. Venereol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0560.1995.tb00734.x","article-title":"Lichen striatus\u2014A chameleon: An histopathological and immunohistological study of forty-one cases","volume":"22","author":"Gianotti","year":"1995","journal-title":"J. Cutan. Pathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1034\/j.1600-0560.2001.280202.x","article-title":"Lichen striatus: Histological, immunohistochemical, and ultrastructural study of 37 cases","volume":"28","author":"Zhang","year":"2001","journal-title":"J. Cutan. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/cup.12768","article-title":"Lichen striatus with syringotropism and hyperplasia of eccrine gland cells: A rare phenomenon that should not be confused with syringotropic mycosis fungoides","volume":"43","author":"Wang","year":"2016","journal-title":"J. Cutan. Pathol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/DAD.0000000000001448","article-title":"Pityriasis lichenoides: A large histopathological case series with a focus on adnexotropism","volume":"42","author":"Menzinger","year":"2020","journal-title":"Am. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1440-0960.2002.00564.x","article-title":"Acral pityriasis lichenoides","volume":"43","author":"Kossard","year":"2002","journal-title":"Australas. J. Dermatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1097\/00000372-200606000-00052","article-title":"Keratosis lichenoides chronica: Proposal of a concept","volume":"28","year":"2006","journal-title":"Am. J. Dermatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1600-0560.1998.tb01723.x","article-title":"Lichen planoporitis: Keratosis lichenoides chronica revisited","volume":"25","author":"Kossard","year":"1998","journal-title":"J. Cutan. Pathol."},{"key":"ref_41","first-page":"260","article-title":"Segmental lichen aureus in a young woman with spontaneous improvement","volume":"12","author":"Zhao","year":"2014","journal-title":"J. Dtsch. Dermatol Ges."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/DAD.0b013e31828b4428","article-title":"Lichen aureus: An unusual histopathological presentation: A case report and a review of literature","volume":"36","author":"Aung","year":"2014","journal-title":"Am. J. Dermatol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1684\/ejd.2016.2767","article-title":"Lichen aureus: Clinicopathological features in a Chinese series","volume":"26","author":"Zeng","year":"2016","journal-title":"Eur. J. Dermatol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jaad.2009.03.014","article-title":"Folliculotropic mycosis fungoides: Clinicopathological features and outcome in a series of 20 cases","volume":"62","author":"Muniesa","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jaad.2008.11.006","article-title":"Two cases of syringotropic cutaneous T-cell lymphoma and review of the literature","volume":"61","author":"Yost","year":"2009","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1001\/archdermatol.2010.101","article-title":"Folliculotropic mycosis fungoides: Single-center study and systematic review","volume":"146","author":"Lehman","year":"2010","journal-title":"Arch. Dermatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/PAS.0b013e3182036ce7","article-title":"Syringotropic mycosis fungoides: A rare variant of the disease with peculiar clinicopathologic features","volume":"3","author":"Pileri","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/S0046-8177(03)00401-5","article-title":"Combined folliculotropic\/syringotropic cutaneous T-cell lymphoma without epidermal involvement: Report of 2 cases and pathogenic implications","volume":"34","author":"Jacobs","year":"2003","journal-title":"Hum. Pathol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/DAD.0b013e3181af1d24","article-title":"Perniosis: Clinical and histopathological analysis","volume":"32","author":"Boada","year":"2010","journal-title":"Am. J. Arch. Dermatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1067\/mjd.2001.117861","article-title":"A histologic and immunohistochemical study of chilblains","volume":"45","author":"Cribier","year":"2001","journal-title":"J. Am. Acad. Arch. Dermatol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00005792-200105000-00004","article-title":"Clinical and histopathologic features and immunologic variables in patients with severe chilblains. A study of the relationship to lupus erythematosus","volume":"80","author":"Viguier","year":"2001","journal-title":"Medicine"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5858\/arpa.2020-0613-SA","article-title":"Histopathologic Features of Chilblainlike Lesions Developing in the Setting of the Coronavirus Disease 2019 (COVID-19) Pandemic","volume":"145","author":"Sohier","year":"2021","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.jaad.2020.05.145","article-title":"Chilblain-like acral lesions during the COVID-19 pandemic (\u201cCOVID toes\u201d): Histologic, immunofluorescence, and immunohistochemical study of 17 cases","volume":"83","author":"Kanitakis","year":"2020","journal-title":"J. Am. Acad. Arch. Dermatol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/2\/20\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:05:12Z","timestamp":1760162712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/2\/20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,21]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6]]}},"alternative-id":["dermatopathology8020020"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology8020020","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,21]]}}}