{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T13:05:22Z","timestamp":1772370322582,"version":"3.50.1"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Mycosis fungoides (MF) is a subtype of primary cutaneous T-cell lymphoma (CTCL) with an indolent course that rarely progresses. Histologically, the lesions display a superficial lymphocytic infiltrate with epidermotropism of neoplastic T-cells. Hypopigmented MF is a rare variant that presents with hypopigmented lesions and is more likely to affect young patients. The etiology of the hypopigmentation is unclear. The aim of this study was to assess melanocyte loss in MF through immunohistochemistry (IHC) with SOX10. Twenty cases were evaluated, including seven of the hypopigmented subtype. The neoplastic epidermotropic infiltrate consisted predominantly of CD4+ T-cells in 65% of cases; CD8+ T-cells were present in moderate to abundant numbers in most cases. SOX10 IHC showed a decrease or focal complete loss of melanocytes in 50% of the cases. The predominant neoplastic cell type (CD4+\/CD8+), age, race, gender, histologic features, and reported clinical pigmentation of the lesions were not predictive of melanocyte loss. A significant loss of melanocytes was observed in 43% of hypopigmented cases and 54% of conventional cases. Additional studies will increase our understanding of the relationship between observed pigmentation and the loss of melanocytes in MF.<\/jats:p>","DOI":"10.3390\/dermatopathology8030034","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T04:32:49Z","timestamp":1625718769000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3284-9602","authenticated-orcid":false,"given":"Cynthia Reyes","family":"Barron","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7301-8274","authenticated-orcid":false,"given":"Bruce R.","family":"Smoller","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bagherani, N., and Smoller, B.R. (2016). An overview of cutaneous T cell lymphomas. F1000Res, 5.","DOI":"10.12688\/f1000research.8829.1"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1002\/ajh.25577","article-title":"Mycosis fungoides and Sezary syndrome: 2019 update on diagnosis, risk-stratification, and management","volume":"94","author":"Hristov","year":"2019","journal-title":"Am. J. Hematol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1111\/jdv.16325","article-title":"Mycosis fungoides: Developments in incidence, treatment and survival","volume":"34","author":"Kaufman","year":"2020","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1600-0560.2008.01120.x","article-title":"Mycosis fungoides: What do\/do not we know?","volume":"35","author":"Smoller","year":"2008","journal-title":"J. Cutan. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1200\/JCO.2009.27.7665","article-title":"Survival outcomes and prognostic factors in mycosis fungoides\/Sezary syndrome: Validation of the revised International Society for Cutaneous Lymphomas\/European Organisation for Research and Treatment of Cancer staging proposal","volume":"28","author":"Agar","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cup.13384","article-title":"Confocal microscopy features of patch-stage mycosis fungoides and their correlation with horizontal histopathological sections. A case series","volume":"46","author":"Broggi","year":"2019","journal-title":"J. Cutan. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/ijd.14925","article-title":"Dermoscopy in differential diagnosis of inflammatory dermatoses and mycosis fungoides","volume":"59","author":"Bilgic","year":"2020","journal-title":"Int. J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clindermatol.2019.01.004","article-title":"Mycosis fungoides: A great imitator","volume":"37","author":"Hodak","year":"2019","journal-title":"Clin. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/cup.12217","article-title":"Hypopigmented mycosis fungoides in childhood and adolescence: A long-term retrospective study","volume":"40","author":"Castano","year":"2013","journal-title":"J. Cutan. Pathol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/jdv.13843","article-title":"Hypopigmented mycosis fungoides: A retrospective clinicohistopathologic study","volume":"31","author":"Rodney","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.5021\/ad.2020.32.1.14","article-title":"Mycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center","volume":"32","author":"Luo","year":"2020","journal-title":"Ann. Dermatol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.1038\/sj.onc.1206442","article-title":"The importance of having your SOX on: Role of SOX10 in the development of neural crest-derived melanocytes and glia","volume":"22","author":"Mollaaghababa","year":"2003","journal-title":"Oncogene"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1038\/ncb2535","article-title":"Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma","volume":"14","author":"Shakhova","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/cup.12262","article-title":"Loss of melanocytes in hypopigmented mycosis fungoides: A study of 18 patients","volume":"41","author":"Furlan","year":"2014","journal-title":"J. Cutan. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.jaad.2005.08.057","article-title":"Defining early mycosis fungoides","volume":"53","author":"Pimpinelli","year":"2005","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/ijd.13855","article-title":"Hypopigmented mycosis fungoides: A 20-case retrospective series","volume":"57","author":"Amorim","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Martinez Villarreal, A., Gantchev, J., Lagace, F., Barolet, A., Sasseville, D., Odum, N., Charli-Joseph, Y.V., Hernandez Salazar, A., and Litvinov, I.V. (2020). Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients. Cancers, 12.","DOI":"10.3390\/cancers12082007"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.jaad.2008.06.042","article-title":"Hypopigmented T-cell dyscrasia evolving to hypopigmented mycosis fungoides during etanercept therapy","volume":"59","author":"Chuang","year":"2008","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jaad.2017.12.068","article-title":"Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor-alpha therapy","volume":"78","author":"Posligua","year":"2018","journal-title":"J. Am. Acad. Dermatol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/3\/34\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:27:35Z","timestamp":1760164055000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/3\/34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["dermatopathology8030034"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology8030034","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]}}}