{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:07:54Z","timestamp":1790798874218,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T00:00:00Z","timestamp":1634860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>A 66-year-old male presented with a one-month history of persistent pruritic eruptions distributed mainly on the trunk. A punch biopsy from the left upper abdomen revealed focal acantholytic dyskeratosis with mixed inflammatory infiltrate in the dermis composed of numerous eosinophils. Grover\u2019s disease was diagnosed based on the clinical and histopathological findings. Appropriate treatment was initiated but failed to relieve symptoms of itchiness. A further investigation of the hair follicles under mineral oil preparation revealed an infestation of pediculosis pubis. Subsequent treatment with Ivermectin and permethrin cream led to the complete resolution of his symptoms. This case report highlights an unusual and first documented case of Grover\u2019s disease with a concomitant infestation of pediculosis pubis. To date, no reported cases in the literature have associated Grover\u2019s disease with pubic lice infestation. However, there are three reported cases of concurrent scabies and Grover\u2019s disease in the literature. This rare case underscores the clinical value in further investigating treatable underlying conditions in patients with suspected transient acantholytic dermatosis.<\/jats:p>","DOI":"10.3390\/dermatopathology8040052","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T21:44:31Z","timestamp":1635198271000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Rare Case of Transient Acantholytic Dermatosis (AKA. Grover\u2019s Disease) with Concomitant Pediculosis Pubis: An Atypical Presentation and First Documented Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6415-045X","authenticated-orcid":false,"given":"Gehan A.","family":"Pendlebury","sequence":"first","affiliation":[{"name":"College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Oro","sequence":"additional","affiliation":[{"name":"School of Osteopathic Medicine in Arizona, A.T. Still University, Mesa, AZ 85206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew","family":"Merideth","sequence":"additional","affiliation":[{"name":"School of Osteopathic Medicine in Arizona, A.T. Still University, Mesa, AZ 85206, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Rudnick","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, University of Florida, Gainesville, FL 32610, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1001\/archderm.1970.04000040048010","article-title":"Transient acantholytic dermatosis","volume":"101","author":"Grover","year":"1970","journal-title":"Arch. Dermatol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.5826\/dpc.0703a11","article-title":"Grover\u2019s disease: Dermoscopy, reflectance confocal microscopy and histopathological correlation","volume":"7","author":"Lacarrubba","year":"2017","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_3","first-page":"244","article-title":"Transitorische akantholytische Dermatose (M. Grover). Eine Analyse des klinischen Spektrums anhand von 21 histologisch erfassten F\u00e4llen [Transitory acantholytic dermatosis (Grover disease). An analysis of the clinical spectrum based on 21 histologically assessed cases]","volume":"51","author":"Streit","year":"2000","journal-title":"Hautarzt"},{"key":"ref_4","unstructured":"Bragg, B.N., and Simon, L.V. (2020). Pediculosis. StatPearls, StatPearls Publishing."},{"key":"ref_5","first-page":"59","article-title":"Dermoscopic clues to diagnose acantholytic dyskeratosis","volume":"5","author":"Specchio","year":"2015","journal-title":"Dermatol. Pract. Concept."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1440-0960.2012.00955.x","article-title":"Dermatoscopy of Grover\u2019s disease and solitary acantholytic dyskeratoma shows a brown, star-like pattern","volume":"53","author":"Giacomel","year":"2012","journal-title":"Australas. J. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000051647","article-title":"Grover\u2019s disease associated with Sarcoptes scabiei","volume":"202","author":"Kaddu","year":"2001","journal-title":"Dermatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1007\/s001050050685","article-title":"Transitorische akantholytische Dermatose (Grover) bei Sarcoptes-scabiei-Infektion","volume":"48","year":"1997","journal-title":"Hautarzt"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s001050050908","article-title":"Stellungnahme zur Arbeit von E. K\u00f6stler: \u2018Transitorische akantholytische Dermatose (Grover) bei Sarcoptes-scabiei-Infektion\u2019 in Hautarzt (1997) 48:915\u2013917","volume":"50","author":"Jordaan","year":"1999","journal-title":"Hautarzt"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4065\/74.3.229","article-title":"Grover\u2019s disease: Clinicopathologic review of 72 cases","volume":"74","author":"Davis","year":"1999","journal-title":"Mayo Clin. Proc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/01.md.0000152373.07500.6e","article-title":"Ectoparasitism and vector-borne diseases in 930 homeless people from Marseilles","volume":"84","author":"Brouqui","year":"2005","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.4065\/79.5.661","article-title":"Relationship of treatment-resistant head lice to the safety and efficacy of pediculicides","volume":"79","author":"Burkhart","year":"2004","journal-title":"Mayo Clin. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1017\/S0031182005008218","article-title":"Glutamate-gated chloride channels and the mode of action of the avermectin\/milbemycin anthelmintics","volume":"131","author":"Wolstenholme","year":"2005","journal-title":"Parasitology"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00011-008-8007-8","article-title":"Ivermectin inhibits LPS-induced production of inflammatory cytokines and improves LPS-induced survival in mice","volume":"57","author":"Zhang","year":"2008","journal-title":"Inflamm. Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0560.1996.tb01289.x","article-title":"Sudoriferous acrosyringeal acantholytic disease. A subset of Grover\u2019s disease","volume":"23","author":"Hashimoto","year":"1996","journal-title":"J. Cutan. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jaad.2006.01.029","article-title":"Seasonal variation of transient acantholytic dyskeratosis (Grover\u2019s disease)","volume":"55","author":"Scheinfeld","year":"2006","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e173","DOI":"10.1097\/RLU.0000000000000252","article-title":"Grover disease (transient acantholytic dermatosis) in acute myeloid leukemia on FDG PET\/CT","volume":"39","author":"Zhu","year":"2014","journal-title":"Clin. Nucl. Med."},{"key":"ref_18","first-page":"410","article-title":"Incidence of transient acantholytic dermatosis (Grover\u2019s disease) in a hospital setting","volume":"198","author":"French","year":"1999","journal-title":"Dermatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1346-8138.2006.00041.x","article-title":"Transient acantholytic dermatosis (Grover\u2019s disease) in a renal transplant patient","volume":"33","author":"Boutli","year":"2006","journal-title":"J. Dermatol."},{"key":"ref_20","first-page":"126592","article-title":"Grover\u2019s Disease after Heart Transplantation: A Case Report","volume":"2012","author":"Ippoliti","year":"2012","journal-title":"Case Rep. Transplant."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0190-9622(96)90715-X","article-title":"Transient acantholytic dermatosis (Grover\u2019s disease): A global perspective","volume":"35","author":"Parsons","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1046\/j.1365-2133.2000.03574.x","article-title":"Grover\u2019s disease secondary to ribavirin","volume":"142","author":"Antunes","year":"2000","journal-title":"Br. J. Dermatol."},{"key":"ref_23","first-page":"175","article-title":"Grover disease (transient acantholytic dermatosis) induced by anastrozole","volume":"88","author":"Crockett","year":"2011","journal-title":"Cutis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0190-9622(93)70169-T","article-title":"Transient acantholytic dermatosis induced by recombinant human interleukin 4","volume":"29","author":"Mahler","year":"1993","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000092836","article-title":"Grover\u2019s disease induced by cetuximab","volume":"213","author":"Tscharner","year":"2006","journal-title":"Dermatology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/S1470-2045(12)70413-8","article-title":"Cutaneous toxicities of RAF inhibitors","volume":"14","author":"Anforth","year":"2013","journal-title":"Lancet Oncol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40425-016-0151-z","article-title":"Grover\u2019s-like drug eruption in a patient with metastatic melanoma under ipilimumab therapy","volume":"4","author":"Koelzer","year":"2016","journal-title":"J. Immunother. Cancer"}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/4\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:21:04Z","timestamp":1760167264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/8\/4\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,22]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["dermatopathology8040052"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology8040052","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,22]]}}}