{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:11:04Z","timestamp":1783429864791,"version":"3.54.6"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Background: Fibrotic diseases pose a problem for overall health due to their chronic, progressive nature; the lack of a cure; and the fact that such conditions are largely refractory to current medical and surgical treatment practices. Objective: The aim of the present study was to report the physiological stimulation of synthesis and lysis of extracellular matrix proteins during the treatment of primary lymphedema. Material and Methods: A clinical trial was conducted involving the analysis of changes in type I and III collagen fibers and elastic fibers as well as the thickness of the epidermis and dermis in 10 histological fields. Samples were taken from the skin before and after intensive treatment using the Godoy Method\u00ae and adapted to the treatment of fibrosis in a patient with a clinical diagnosis of lower limb lymphedema. Slides were stained with orcein, hematoxylin and eosin, picrosirius red, and Gomori\u2019s reticulin stains. Weibel\u2019s multipoint method was used for the morphometric evaluation. The data were compared using the t-test with a 95% confidence interval. Results: Significant changes were detected in all aspects of interest (thickness of the epidermis and dermis, type I and III collagen fibers, and elastic fibers). Conclusion: The present findings demonstrate the physiological stimulation of synthesis and lysis of the main components of an extracellular matrix, such as type I and III collagen fibers and elastic fibers, as well as a reduction in the thickness of the epidermis and dermis in cases of fibrosis through adequate stimulation of the lymphatic system.<\/jats:p>","DOI":"10.3390\/dermatopathology9010001","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T06:55:03Z","timestamp":1640674503000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Stimulation of Synthesis and Lysis of Extracellular Matrix Proteins in Fibrosis Associated with Lymphedema"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5424-7787","authenticated-orcid":false,"given":"Jose Maria","family":"Pereira de Godoy","sequence":"first","affiliation":[{"name":"Department of Cardiology and Cardiovascular Surgery, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), CNPq (National Council for Research and Development), Floriano Peixoto, Sao Jose do Rio Preto 15020-010, Brazil"},{"name":"Postgraduate Program Stricto Sensu, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), Sao Jose do Rio Preto 15020-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3725-7961","authenticated-orcid":false,"given":"Maria de Fatima","family":"Guerreiro Godoy","sequence":"additional","affiliation":[{"name":"Postgraduate Program Stricto Sensu, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), Sao Jose do Rio Preto 15020-010, Brazil"},{"name":"Research Group at Godoy Clinic, Sao Jose do Rio Preto 15020-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9463-7608","authenticated-orcid":false,"given":"Henrique Jose","family":"Pereira de Godoy","sequence":"additional","affiliation":[{"name":"Research Group at Godoy Clinic, Sao Jose do Rio Preto 15020-010, Brazil"},{"name":"Department of General Surgery, S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), Sao Jose do Rio Preto 15020-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8865-4313","authenticated-orcid":false,"given":"Dalisio","family":"De Santi Neto","sequence":"additional","affiliation":[{"name":"Hospital Affiliated with S\u00e3o Jos\u00e9 do Rio Preto School of Medicine (FAMERP), Sao Jose do Rio Preto 15020-010, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.115.138115","article-title":"Epigenetic modulation of collagen1a1: Therapeutic implications in fibrosis and endometriosis","volume":"94","author":"Zheng","year":"2016","journal-title":"Biol. 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Med."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/1\/1\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:54:33Z","timestamp":1760169273000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/1\/1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["dermatopathology9010001"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology9010001","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]}}}