{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:36:24Z","timestamp":1780097784862,"version":"3.54.0"},"reference-count":11,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Primary cutaneous gamma-delta T-cell lymphoma (CGD-TCL) is a rare cutaneous lymphoma. Panniculitis-like T-cell lymphoma (SPTCL) has a better prognosis than CGD-TCL. SPTCL is sometimes associated with autoimmune disease. A 64-year-old Japanese female with a history of dermatomyositis presented with subcutaneous nodules on the upper extremities and exacerbated dermatomyositis. A skin biopsy showed lobular panniculitis, a vacuolar interface change, and a dermal mucin deposit. Fat cells rimmed by neoplastic cells, fat necrosis, and karyorrhexis were observed. The atypical lymphoid cells showed CD3+, CD4\u2212, CD8+, granzyme B+, CD20\u2212, and CD56\u2212. Polymerase chain reaction analysis demonstrated a T-cell receptor rearrangement. The patient was initially diagnosed with SPTCL, so the dose of prednisone was raised from 7.5 to 50 mg daily (1 mg\/kg). After one month, erythematous nodules regressed, and muscle symptoms improved. Subsequently, prednisone was tapered, and cyclosporin A was added. After one year, the patient remained symptom-free and continued taking 7.5 mg prednisone and 100 mg cyclosporin A daily. Afterward, we immunostained skin samples with antibodies against TCR-\u00df and \u03b4 and found positive TCR-\u03b4 and negative TCR-\u00df. Therefore, we corrected the diagnosis to CGD-TCL, although the clinical course and the presence of dermatomyositis were reminiscent of SPTCL.<\/jats:p>","DOI":"10.3390\/dermatopathology9020018","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T16:49:57Z","timestamp":1651250997000},"page":"143-147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Primary Cutaneous Gamma-Delta T-Cell Lymphoma Initially Diagnosed as Subcutaneous Panniculitis-like T-Cell Lymphoma with Dermatomyositis"],"prefix":"10.3390","volume":"9","author":[{"given":"Chika","family":"Hirata","sequence":"first","affiliation":[{"name":"Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kozo","family":"Nakai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Kurasawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City General Hospital, Osaka 534-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City General Hospital, Osaka 534-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Kuniyuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City General Hospital, Osaka 534-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9099-7673","authenticated-orcid":false,"given":"Keiko","family":"Yamagami","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Osaka City General Hospital, Osaka 534-0021, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiko","family":"Ohsawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Tsuruta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","unstructured":"Elder, D.E., Massi, D., and Scolyer, R.A. (2018). Primary cutaneous periferal T-cell lymphomas, rare subtypes. WHO Classification of Skin Tumours, IARC Press. 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Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/DAD.0b013e318289c9b8","article-title":"Rapid progression of primary cutaneous gamma-delta T-cell lymphoma with an initial indolent clinical presentation","volume":"36","author":"Alexander","year":"2014","journal-title":"Am. J. Dermatopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3389\/fonc.2020.00133","article-title":"Primary Cutaneous Gamma-Delta T-Cell Lymphoma With Long-Term Indolent Clinical Course Initially Mimicking Lupus Erythematosus Profundus","volume":"10","author":"Fleischer","year":"2020","journal-title":"Front. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1007\/s10067-013-2258-7","article-title":"The presenting manifestations of subcutaneous panniculitis-like T-cell lymphoma and T-cell lymphoma and cutaneous \u03b3\u03b4 T-cell lymphoma may mimic those of rheumatic diseases: A report of 11 cases","volume":"32","author":"Yi","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_11","first-page":"377","article-title":"A Study on Dermatomyositis and the Relation to Malignancy","volume":"47","author":"Tudorancea","year":"2021","journal-title":"Curr. Health Sci. J."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/2\/18\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:04:15Z","timestamp":1760137455000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/2\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,29]]},"references-count":11,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["dermatopathology9020018"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology9020018","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,29]]}}}