{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:01:09Z","timestamp":1760238069683,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Lobular capillary hemangioma (LCH-PG) is a type of pyogenic granuloma characterized by proliferating blood vessels that resemble conventional granulation tissue. Granulation tissue is very often seen in association with ingrown toenails. Despite the close relationship between both entities, LCH-PG shows clinically different behaviors, such as rapid growth and frequent recurrence. Currently, it is unknown exactly how the different etiological factors contribute to the formation of differences between entities. We present a case of a large LCH-PG associated with chronic onychocryptosis in a 26-year-old man. Histopathological features included extensive signs of ulceration, hyperkeratosis, and patchy epidermal acanthosis with the presence of fibrous septa with lobular areas beneath the ulcerative area. The presence of stroma with a marked proliferation of blood vessels with wall thickening and mixed-type inflammatory changes was also characteristic. In advanced stages of onychocryptosis, as presented here, conventional granulation tissue or pyogenic granuloma can be clinically difficult to distinguish from other benign or malignant neoplasms. Histological examination is mandatory, and excisional biopsy can provide a definitive diagnosis.<\/jats:p>","DOI":"10.3390\/dermatopathology9030031","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T21:20:59Z","timestamp":1658784059000},"page":"271-276","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large Lobular Capillary Hemangioma Associated with Ingrown Toenail: Histopathological Features and Case Report"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-9322","authenticated-orcid":false,"given":"Antonio","family":"C\u00f3rdoba-Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Departamento de Podolog\u00eda, Universidad de Sevilla, C\/Avicena s\/n, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6991-1422","authenticated-orcid":false,"given":"Mar\u00eda Dolores","family":"Jim\u00e9nez-Cristino","sequence":"additional","affiliation":[{"name":"Departamento de Podolog\u00eda, Universidad de Sevilla, C\/Avicena s\/n, 41009 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria Eugenia","family":"C\u00f3rdoba-Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Private Practice, C\/Dr. Fleming 13, Bajo B, Castilleja de la Cuesta, 41950 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1440-1827.2005.01843.x","article-title":"Pyogenic granuloma of the oral cavity: Comparative study of its clinicopathological and immunohistochemical features","volume":"55","author":"Epivatianos","year":"2005","journal-title":"Pathol. Int."},{"key":"ref_2","first-page":"6","article-title":"Onychocryptosis: A simple classification system","volume":"1","author":"Kline","year":"2008","journal-title":"Foot Ankle J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1365-2133.2010.09906.x","article-title":"Periungual and subungual pyogenic granuloma","volume":"163","author":"Piraccini","year":"2010","journal-title":"Br. J. Dermatol."},{"key":"ref_4","first-page":"41","article-title":"Malignant melanoma masqueraded as ingrown toe nail","volume":"165","author":"Adnan","year":"2014","journal-title":"Clin. Ter."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"bcr2017219715","DOI":"10.1136\/bcr-2017-219715","article-title":"Marjolin\u2019s squamous cell carcinoma of the hallux following recurrent ingrown toenail infections","volume":"2017","author":"Abdul","year":"2017","journal-title":"BMJ Case. Rep."},{"key":"ref_6","first-page":"e13289","article-title":"Uncommon presentation of pigmented paraungual basal cell carcinoma on the first toe treated with total excision","volume":"33","author":"Bagot","year":"2020","journal-title":"Dermatol. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e177","DOI":"10.1111\/1346-8138.14251","article-title":"Pyogenic granuloma-like Kaposi\u2019s sarcoma on the first toe","volume":"45","author":"Korekawa","year":"2018","journal-title":"J. Dermatol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/DAD.0b013e3181930da9","article-title":"Ingrowntoenail: Histopathologic and immunohistochemical study","volume":"31","year":"2009","journal-title":"Am. J. Dermatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.7547\/87507315-92-5-306","article-title":"Amelanotic melanoma masquerading as an ingrown toenail","volume":"92","author":"Lemont","year":"2002","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_10","first-page":"2050313X17740514","article-title":"Surgical management of extensive hypertrophic scarring of the halluces secondary to a decade of untreated onychocryptosis: An illustrative case report","volume":"5","author":"Samaras","year":"2017","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.7547\/0970475","article-title":"Leiomyosarcoma of the foot: A case study","volume":"97","author":"Engel","year":"2007","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00000478-198010000-00007","article-title":"Lobular capillary hemangioma: The underlying lesion of pyogenic granuloma. A study of 73 cases from the oral and nasal mucous membranes","volume":"4","author":"Mills","year":"1980","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.1468-3083.2001.00266.x","article-title":"Pyogenic granuloma:Who are you?","volume":"15","author":"Grosshans","year":"2001","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/cup.13970","article-title":"Oral pyogenic granuloma: An 18-year retrospective clinicopathological and immunohistochemical study","volume":"48","author":"Ribeiro","year":"2021","journal-title":"J. Cutan. Pathol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1111\/cup.13769","article-title":"PAS and GMS utility in derpathopatology. Review of the current medical literature","volume":"47","author":"Shalin","year":"2020","journal-title":"J. Cutan. Pathol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/modpathol.2012.148","article-title":"Pyogenic granuloma, an impaired wound healing process, linked to vascular growth driven by FLT4 and the nitric oxide pathway","volume":"26","author":"Godfraind","year":"2013","journal-title":"Mod. Pathol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1034\/j.1600-0560.2000.027008400.x","article-title":"Apoptosis and expression of Bax\/Bcl-2 proteins in pyogenic granuloma: A comparative study with granulation tissue and capillary hemangioma","volume":"27","author":"Nakamura","year":"2000","journal-title":"J. Cutan. Pathol."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/3\/31\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:55:54Z","timestamp":1760140554000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/3\/31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,25]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,9]]}},"alternative-id":["dermatopathology9030031"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology9030031","relation":{},"ISSN":["2296-3529"],"issn-type":[{"type":"electronic","value":"2296-3529"}],"subject":[],"published":{"date-parts":[[2022,7,25]]}}}