{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T13:49:40Z","timestamp":1767016180992,"version":"build-2065373602"},"reference-count":11,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare tumor that affects elderly individuals and presents a poor prognosis. Skin is the most common site of involvement, accounting for 89% of the cases. Extracutaneous organs, especially bone marrow, lymph nodes, and peripheral blood, can be involved at the time of diagnosis. We report a case of BPDCN in a child, presenting with a cutaneous lesion mimicking lymphoma or leukemia cutis. The histologic findings revealed a dense diffuse infiltration by monomorphic agranular medium-sized blast cells with sparing of the grenz zone, whose first immunophenotypic profile raised the possibility of diagnosing B lymphoblastic lymphoma or leukemia. However, the absence of CD10 expression and strongly positive expression for CD4, CD56, CD45RA, and the plasmacytoid dendritic cell-associated antigens, including CD123, supported the definite diagnosis of BPDCN. The patient responded well to a systemic combination chemotherapy regimen, modified from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) protocol for anaplastic large cell lymphoma (ALCL), that differed from the established recommendation using ALL protocol. Owing to the patient\u2019s excellent treatment outcome, this regimen could represent an effective alternative regimen for BPDCN in children.<\/jats:p>","DOI":"10.3390\/dermatopathology9040038","type":"journal-article","created":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T01:52:21Z","timestamp":1665193941000},"page":"321-326","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Rare Case of Blastic Plasmacytoid Dendritic Cell Neoplasm in a Child Mimicking Lymphoma\/Leukemia Cutis"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4155-5016","authenticated-orcid":false,"given":"Phanitchanat","family":"Phusuphitchayanan","sequence":"first","affiliation":[{"name":"Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4789-7233","authenticated-orcid":false,"given":"Voraphol","family":"Vejjabhinanta","sequence":"additional","affiliation":[{"name":"Dermatologic Surgery and Laser Division, Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-4543","authenticated-orcid":false,"given":"Chayamon","family":"Takpradit","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Poonnawis","family":"Sudtikoonaseth","sequence":"additional","affiliation":[{"name":"Dermatopathology Division, Institute of Dermatology, Department of Medical Services, Ministry of Public Health, Bangkok 10400, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasmon","family":"Chairatchaneeboon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamonpan","family":"Kiatvichukul","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanya","family":"Sukpanichnant","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"ref_1","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., and Thiele, J. (2017). Blastic plasmacytoid dendritic cell neoplasm. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC. [revised 4th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.1182\/bloodadvances.2020002474","article-title":"Blastic Plasmacytoid Dendritic Cell Neoplasms: Results of an International Survey on 398 Adult Patients","volume":"4","author":"Laribi","year":"2020","journal-title":"Blood Adv."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.3324\/haematol.2010.026179","article-title":"Blastic Plasmacytoid Dendritic Cell Neoplasm in Children: Diagnostic Features and Clinical Implications","volume":"95","author":"Jegalian","year":"2010","journal-title":"Haematologica"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/his.13340","article-title":"Clinicopathological Analysis of 46 Cases With CD4+ and\/or CD56+ Immature Haematolymphoid Malignancy: Reappraisal of Blastic Plasmacytoid Dendritic Cell and Related Neoplasms","volume":"71","author":"Suzuki","year":"2017","journal-title":"Histopathology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/pbc.24125","article-title":"Results of AIEOP LNH-97 Protocol for the Treatment of Anaplastic Large Cell Lymphoma of Childhood","volume":"59","author":"Pillon","year":"2012","journal-title":"Pediatr. Blood Cancer."},{"key":"ref_6","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., and Thiele, J. (2017). B-Lymphoblastic Leukaemia\/Lymphoma, Not Otherwise Specified (NOS). WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, IARC. [revised 4th ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/cup.13099","article-title":"Blastic Plasmacytoid Dendritic Cell Neoplasm With Centrocyte-Like Morphology Clinically Simulating a Melanocytic Nevus","volume":"45","author":"Chu","year":"2018","journal-title":"J. Cutan. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1097\/PAS.0000000000001316","article-title":"Dual Expression of TCF4 and CD123 Is Highly Sensitive and Specific for Blastic Plasmacytoid Dendritic Cell Neoplasm","volume":"43","author":"Sukswai","year":"2019","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jdermsci.2020.01.010","article-title":"Cutaneous Lymphoma in Japan, 2012\u20132017: A Nationwide Study","volume":"97","author":"Fujii","year":"2020","journal-title":"J. Dermatol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s12185-020-03070-x","article-title":"Pediatric blastic plasmacytoid dendritic cell neoplasm: Report of four cases and review of literature","volume":"113","author":"Liao","year":"2021","journal-title":"Int. J. Hematol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.hoc.2020.01.008","article-title":"Blastic Plasmacytoid Dendritic Cell Neoplasm in Children","volume":"34","author":"Li","year":"2020","journal-title":"Hematol. Oncol. Clin. N. Am."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/4\/38\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:44:25Z","timestamp":1760143465000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/4\/38"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["dermatopathology9040038"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology9040038","relation":{},"ISSN":["2296-3529"],"issn-type":[{"type":"electronic","value":"2296-3529"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}