{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:01:13Z","timestamp":1784246473634,"version":"3.55.0"},"reference-count":22,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Introduction: Cutaneous metastases represent 2% of skin tumors, with an overall incidence of 5.3%. Although rare, clinical presentations of cutaneous metastasis vary and can be mistaken for benign and malignant skin conditions. Methodology: This was a descriptive, retrospective review of all patients diagnosed with cutaneous metastasis seen at the Department of Dermatology from January 2013 to December 2019. Clinical and histopathologic data from the patients were collated from medical records, and slides were retrieved for review. Results: A total of 115 patients were included and 122 slides reviewed. There were more female than males, the mean age was 52.3 \u00b1 14.0 years of age. The most common primary cancer was the breast, and accordingly, the most common location was anterior chest. Among the 122 slides reviewed from 104 patients, the most common histologic type was adenocarcinoma (72.1%), and showed the infiltrative pattern (26.2%). Other histologic types seen were melanoma (13.1%), leukemic infiltrates (11.5%), squamous origin (2.5%), and epithelioid sarcoma (0.8%). Lymphovascular invasion and dermal sclerosis were observed. Immunohistochemical stains were performed in only 13.9% of the cases. There was a high concurrence of the clinical with the histopathologic diagnosis (95.6%). Conclusion: Although rare, patients with cutaneous metastasis may present in dermatology clinics. Knowledge of clinical features and low threshold for doing biopsies may prove useful for these patients. Similarly, dermatopathologists should be able to recognize histologic features of cutaneous metastasis morphologically. Histologic features may be subtle and may be reminiscent of benign inflammatory conditions, hence judicious use of immunohistochemical staining is recommended.<\/jats:p>","DOI":"10.3390\/dermatopathology9040046","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T03:59:46Z","timestamp":1670558386000},"page":"392-407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical and Histopathologic Profile of Patients with Cutaneous Metastasis in a Tertiary Hospital in the Philippines"],"prefix":"10.3390","volume":"9","author":[{"given":"Jolene Kristine Gatmaitan","family":"Dumlao","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of the Philippines, Philippine General Hospital, Manila 1000, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen Liesl A.","family":"Cubillan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of the Philippines, Philippine General Hospital, Manila 1000, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Paolo David S.","family":"Villena","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of the Philippines, Philippine General Hospital, Manila 1000, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.0303-6987.2004.00207.x","article-title":"Cutaneous metastasis: A clinical, pathological, and immunohistochemical appraisal","volume":"31","author":"Saeed","year":"2004","journal-title":"J. Cutan. Pathol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/DAD.0b013e31823069cf","article-title":"Cutaneous metastases from internal malignancies: A clinicopathologic and immunohistochemical review","volume":"34","author":"Alcaraz","year":"2012","journal-title":"Am. J. Dermatopathol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"793937","DOI":"10.1155\/2014\/793937","article-title":"A Clinicopathological and Immunohistochemical Correlation in Cutaneous Metastases from Internal Malignancies: A Five-Year Study","volume":"2014","author":"Nibhoria","year":"2014","journal-title":"J. Skin Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.SMJ.0000053676.73249.E5","article-title":"Cutaneous metastasis: A meta-analysis of data","volume":"96","author":"Krathen","year":"2003","journal-title":"South Med. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1001\/archderm.143.5.613","article-title":"Clinicopathologic Correlation of Cutaneous Metastases","volume":"143","author":"Sariya","year":"2007","journal-title":"Arch. Dermatol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1001\/archderm.1972.01620090034008","article-title":"Patterns of Cutaneous Metastasis","volume":"105","author":"Brownstein","year":"1972","journal-title":"Arch. Dermatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1111\/j.1600-0560.2009.01469.x","article-title":"Skin metastasis: A pathologist\u2019s perspective","volume":"37","author":"Hussein","year":"2010","journal-title":"J. Cutan. Pathol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1097\/DAD.0b013e3181b348f8","article-title":"Cutaneous metastases: A study of 78 biopsies from 69 patients","volume":"32","year":"2010","journal-title":"Am. J. Dermatopathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-4632.2012.05650.x","article-title":"Cutaneous metastasis: Clinicopathological study of 72 patients from a tertiary care center in Lebanon","volume":"53","author":"Khalifeh","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.ad.2018.07.012","article-title":"Epidemiologic and Histopathologic Characterization of Cutaneous Metastases in Patients Who Visited 2 Hospitals in Santiago de Chile between 2005 and 2017","volume":"110","author":"Kaplan","year":"2019","journal-title":"Actas Dermosifiliogr."},{"key":"ref_11","first-page":"50","article-title":"Skin Metastasis from Laryngeal Carcinoma: A Case Report","volume":"36","author":"Perez","year":"2003","journal-title":"Philipp. Sci. J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.32412\/pjohns.v26i1.607","article-title":"Dermal Metastasis from Nasopharyngeal Carcinoma: A Rare Form of Metastasis","volume":"26","year":"2011","journal-title":"Philipp. J. Otolaryngol. Neck Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1111\/j.1468-3083.2008.02590.x","article-title":"Cutaneous metastases from different internal malignancies: A clinical and prognostic appraisal","volume":"22","author":"Hu","year":"2008","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_14","first-page":"167","article-title":"Cutaneous metastases from internal cancers","volume":"17","author":"Benmously","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ajd.12194","article-title":"A retrospective review of cutaneous metastases at the National Skin Centre Singapore","volume":"56","author":"Gan","year":"2015","journal-title":"Australas. J. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-4632.2012.05635.x","article-title":"Patterns of skin metastases: A review of 25years\u2019 experience at a single cancer center","volume":"53","author":"Wong","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"125","DOI":"10.4103\/0378-6323.60548","article-title":"Cutaneous metastases of internal malignancies: A clinicopathologic study","volume":"76","author":"Chopra","year":"2010","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.jaad.2015.10.012","article-title":"The distribution of cutaneous metastases correlates with local immunologic milieu","volume":"74","author":"Schulman","year":"2016","journal-title":"J. Am. Dermatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4103\/ijdpdd.ijdpdd_29_18","article-title":"Interstitial pattern of cutaneous metastasis and its diagnosic pitfalls: A report of three cases","volume":"5","author":"Panjwani","year":"2018","journal-title":"Indian J. Dermatopathol. Diagn. Dermatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"e1393134","DOI":"10.1080\/2162402X.2017.1393134","article-title":"Eosinophils: The unsung heroes in cancer ?","volume":"7","author":"Varricchi","year":"2018","journal-title":"Oncoimmunology"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"943","DOI":"10.5858\/arpa.2018-0051-RA","article-title":"Cutaneous Metastasis: A Review and Diagnostic Approach to Tumors of Unknown Origin","volume":"143","author":"Habermehl","year":"2018","journal-title":"Arch. Pathol. Lab. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1200\/JCO.2014.55.4634","article-title":"Efficacy of skin-directed therapy for cutaneous metastases from advanced cancer: A meta-analysis","volume":"32","author":"Spratt","year":"2014","journal-title":"J. Clin. 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