{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:33:44Z","timestamp":1790472824845,"version":"4.1.0"},"reference-count":11,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatopathology"],"abstract":"<jats:p>Cystic neutrophilic granulomatous mastitis is a rarely reported, benign, mastitis that is not associated with lactation. The pathophysiology is still unknown; however, there is often a relationship with Corynebacterium kroppenstedtii. Cystic neutrophilic mastitis can have deep seated tender nodules and cutaneous ulceration which can clinically resemble pyoderma gangrenous. It can be treatment refractory and can progress to a point where mastectomy is required. This case series reports two patients treated with adalimumab with remission of disease. One patient first received dapsone with remission of symptoms, but incompatible side effects resulted in discontinuation. Both dapsone and adalimumab appear to provide disease remission in patients with cystic neutrophilic granulomatous mastitis.<\/jats:p>","DOI":"10.3390\/dermatopathology9040047","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T03:21:52Z","timestamp":1670988112000},"page":"408-412","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cystic Neutrophilic Granulomatous Mastitis Treatment with Consecutive Dapsone and Adalimumab"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0761-231X","authenticated-orcid":false,"given":"Samir","family":"Kamat","sequence":"first","affiliation":[{"name":"Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-6890","authenticated-orcid":false,"given":"William","family":"Schaffenburg","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4939-6395","authenticated-orcid":false,"given":"Michelle","family":"Bongiorno","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Walter Reed National Military Medical Center, Bethesda, MD 20814, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1002\/ccr3.1801","article-title":"Cystic neutrophilic granulomatous mastitis with corynebacterium and staphylococcus mimicking breast carcinoma","volume":"6","author":"Wang","year":"2018","journal-title":"Clin. Case Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e01034","DOI":"10.1016\/j.idcr.2020.e01034","article-title":"Whole genome sequence of Corynebacterium kroppenstedtii isolated from a case of recurrent granulomatous mastitis","volume":"23","author":"Tan","year":"2020","journal-title":"IDCases"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jclinpath-2019-206180","article-title":"Cystic neutrophilic granulomatous mastitis: An update","volume":"73","author":"Wu","year":"2020","journal-title":"J. Clin. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/his.14187","article-title":"Cystic neutrophilic granulomatous mastitis\u2014A review of 12 consecutive cases","volume":"77","author":"Maung","year":"2020","journal-title":"Histopathology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/tbj.13160","article-title":"Cystic neutrophilic granulomatous mastitis: The Cleveland Clinic experience with diagnosis and management","volume":"25","author":"Gautham","year":"2019","journal-title":"Breast J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1177\/1066896919896021","article-title":"Cystic Neutrophilic Granulomatous Mastitis: A Clinicopathological Study With 16s rRNA Sequencing for the Detection of Corynebacteria in Formalin-Fixed Paraffin-Embedded Tissue","volume":"28","author":"Naik","year":"2020","journal-title":"Int. J. Surg. Pathol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.4274\/ejbh.galenos.2021.2021-7-2","article-title":"Cystic Neutrophilic Granulomatous Mastitis Regression with the Tumor Necrosis Factor-\u03b1 Inhibitor, Adalimumab","volume":"18","author":"Chiu","year":"2022","journal-title":"Eur. J. Breast Health"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/ajcp\/aqz200","article-title":"\u201cThick Section\u201d Gram Stain Yields Improved Detection of Organisms in Tissue Sections of Cystic Neutrophilic Granulomatous Mastitis","volume":"153","author":"Sangoi","year":"2020","journal-title":"Am. J. Clin. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.cmi.2020.06.037","article-title":"Cystic neutrophilic granulomatous mastitis: Corynebacterium species-associated infection with distinct histology","volume":"27","author":"Wang","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/1756-185X.14065","article-title":"A rheumatologic approach to granulomatous mastitis: A case series and review of the literature","volume":"24","author":"Ringsted","year":"2021","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/tbj.13219","article-title":"A successful case of etanercept used for idiopathic granulomatous mastitis","volume":"25","author":"Wang","year":"2019","journal-title":"Breast J."}],"container-title":["Dermatopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/4\/47\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:40:56Z","timestamp":1760146856000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2296-3529\/9\/4\/47"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,14]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["dermatopathology9040047"],"URL":"https:\/\/doi.org\/10.3390\/dermatopathology9040047","relation":{},"ISSN":["2296-3529"],"issn-type":[{"value":"2296-3529","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,14]]}}}