{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T12:32:20Z","timestamp":1772022740446,"version":"3.50.1"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The objective of the study is to present the clinico-pathological features of cystic and classic adenomatoid odontogenic tumors (AOTs) in order to identify the differences between the two variants of AOT. Materials and method: The study sample comprised of 41 AOTs, which were categorized into cystic and classic AOTs. Cystic AOTs are diagnosed as such when macroscopic and microscopic evidence of a cyst is present together with histopathological criteria of AOT (WHO\u20132017). Results: The study sample comprised of eleven cystic and thirty classic AOTs. Eight cystic AOTs were regarded as arising from dentigerous cysts as these lesions were attached to the cemento-enamel junction of the impacted teeth. Though not statistically significant, in contrast to classic AOTs which showed female predilection, cystic AOTs were more prevalent in males. Cystic AOTs tend to present as significantly larger lesions compared to classic AOTs (p &lt; 0.02). In both cystic and classic AOTs, duct-like structures and epithelial whorls were the two most prominent histopathological features present in the majority of tumors. Two AOTs with massive amounts of dentinoid occurred in the mandible and presented as large lesions that eroded cortical bone. None of the 12 patients with follow-up information presented with recurrences. Conclusion: Except for the size of the lesion, no significant clinico-pathological differences were observed between cystic and classic AOTs. Therefore the cystic AOTs can be considered as a variant of AOT with enucleation, simple excision, or radical excision as the treatment of choice depending on the extent of the lesion, similar to classic AOTs.<\/jats:p>","DOI":"10.3390\/diagnostics10010003","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T09:50:33Z","timestamp":1576835433000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinico-Pathological Presentations of Cystic and Classic Adenomatoid Odontogenic Tumors"],"prefix":"10.3390","volume":"10","author":[{"given":"Primali Rukmal","family":"Jayasooriya","sequence":"first","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inoka Krishanthi","family":"Rambukewella","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya 20400, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanninayake Mudiyanselage","family":"Tilakaratne","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, University of Malaya, Kuala Lumpur 50603, Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Balapuwaduge Ranjit Rigobert Nihal","family":"Mendis","sequence":"additional","affiliation":[{"name":"Laboratory of Oral and Maxillofacial Pathology, Unit of Oral Medicine &amp; Oral Maxillofacial Pathology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, CUMD, 1206 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9347-3736","authenticated-orcid":false,"given":"Tommaso","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Laboratory of Oral and Maxillofacial Pathology, Unit of Oral Medicine &amp; Oral Maxillofacial Pathology, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, CUMD, 1206 Geneva, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,12,20]]},"reference":[{"key":"ref_1","unstructured":"Philipsen, H.P., and Nikai, H. 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