{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:03:14Z","timestamp":1761490994927,"version":"build-2065373602"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T00:00:00Z","timestamp":1587859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Oocyte donations (OD) represent 4.5% of all in vitro fertilization (IVF) cycles. While OD pregnancies face increased risks of obstetrical complications, especially pregnancy-induced hypertension and pre-eclampsia (PE), little is known about the physiology and the physiopathology of placentation. We performed a prospective case-control study to analyze uterine artery Doppler pulsatility index (UtA-PI) and serum maternal 17\u03b2-estradiol (17\u03b2-E) at 11 + 0 to 13 + 6 weeks\u2019 gestation in singleton pregnancies with different modes of conception. Study groups were: 55 OD, 48 IVF with autologous oocytes from fresh cycles (Autologous-Fresh IVF), 10 IVF with autologous oocytes from frozen cycles (Autologous-Frozen IVF) and 122 spontaneously conceived pregnancies (SC). The mean UtA-PI and serum maternal 17\u03b2-E at 11 to 13 + 6 weeks were significantly lower in OD as compared to SC and autologous IVF, either from fresh or frozen cycles. Oocyte donation presents lower UtA-PI and lower serum 17\u03b2-E in the first trimester of pregnancy. The etiology of these particularr differences is likely multifactorial and deserves further investigation.<\/jats:p>","DOI":"10.3390\/diagnostics10050254","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T04:15:29Z","timestamp":1587960929000},"page":"254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Uterine Artery Doppler and Estrogen Milieu in Oocyte Donation Pregnancies\u2014A Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Luca","family":"Mandia","sequence":"first","affiliation":[{"name":"Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, Italy"},{"name":"Centre for Fetal Research Giorgio Pardi, University of Milan, 20100 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-366X","authenticated-orcid":false,"given":"Paolo","family":"Cavoretto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4499-8805","authenticated-orcid":false,"given":"Piergiorgio","family":"Duca","sequence":"additional","affiliation":[{"name":"Statistical and Biometry Unit, Department of Biomedical and Clinical Sciences, University of Milan, Via G. B. Grassi, 74, 20157 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Candiani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS Ospedale San Raffaele, University Vita-Salute San Raffaele, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9217-3034","authenticated-orcid":false,"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, Italy"},{"name":"Centre for Fetal Research Giorgio Pardi, University of Milan, 20100 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-7689","authenticated-orcid":false,"given":"Valeria","family":"Savasi","sequence":"additional","affiliation":[{"name":"Unit of Obstetrics and Gynecology, Department of Biomedical and Clinical Sciences, ASST Fatebenefratelli Sacco, University of Milan, Via G. B. Grassi, 74, 20157 Milan, Italy"},{"name":"Centre for Fetal Research Giorgio Pardi, University of Milan, 20100 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,26]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2020, March 23). 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