{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:49:37Z","timestamp":1760237377419,"version":"build-2065373602"},"reference-count":17,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T00:00:00Z","timestamp":1589500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare fatal degenerative disease of the central nervous system. The clinical course is characterized by rapid progression of neurological and neuromuscular symptoms. The late stage with loss of consciousness is not well characterized. We report a 62-year-old male patient with sCJD with the clinical picture of a vegetative state\/apallic syndrome, in whom we studied cortical responses using a vibration paradigm. The functional magnetic resonance imaging (fMRI) investigation demonstrated a clear response within the sensorimotor cortex, the cerebellum, the parietal cortex, the insular, and frontal inferior region. The finding of persistent cortical activity on fMRI in a patient with CJD in a state of unconsciousness has implications for the clinical management and for ethical considerations.<\/jats:p>","DOI":"10.3390\/diagnostics10050309","type":"journal-article","created":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T10:53:59Z","timestamp":1589540039000},"page":"309","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Functional Magnetic Resonance Imaging in the Final Stage of Creutzfeldt-Jakob Disease"],"prefix":"10.3390","volume":"10","author":[{"given":"Stefan M.","family":"Golaszewski","sequence":"first","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology, 5020 Salzburg, Austria"},{"name":"Neuroscience Institute, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina","family":"Wutzl","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology, 5020 Salzburg, Austria"},{"name":"Institute for Analysis and Scientific Computing, Technical University of Vienna, 1040 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel F.","family":"Unterrainer","sequence":"additional","affiliation":[{"name":"Institute of Neuroanesthesiology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Florea","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Schwenker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Karl Landsteiner Institute for Neurorehabilitation and Space Neurology, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa N.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Kronbichler","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Centre for Cognitive Neuroscience and Department of Psychology, University of Salzburg, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2819-8827","authenticated-orcid":false,"given":"Frank","family":"Rattay","sequence":"additional","affiliation":[{"name":"Institute for Analysis and Scientific Computing, Technical University of Vienna, 1040 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Nardone","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Department of Neurology, Franz-Tappeiner-Hospital, 39012 Merano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa","family":"Hauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-5533","authenticated-orcid":false,"given":"Johann","family":"Sellner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Department of Neurology, Landesklinikum Mistelbach-G\u00e4nserndorf, 2130 Mistelbach, Austria"},{"name":"Department of Neurology, Klinikum rechts der Isar, Technische Universit\u00e4t M\u00fcnchen, 81675 M\u00fcnchen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Neuroscience Institute, Christian Doppler Medical Center, Paracelsus Medical University, 5020 Salzburg, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/B978-0-444-63945-5.00009-X","article-title":"Sporadic Creutzfeldt-Jakob disease","volume":"153","author":"Zerr","year":"2018","journal-title":"Handb. 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Pain"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/5\/309\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:29:19Z","timestamp":1760174959000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/5\/309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,15]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5]]}},"alternative-id":["diagnostics10050309"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10050309","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2020,5,15]]}}}