{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:52:07Z","timestamp":1760237527812,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T00:00:00Z","timestamp":1590537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: We compared the efficiency of two MRI diffusion weighted imaging (DWI) techniques: DWI with SPIR (DWISPIR) and DWI with STIR (DWISTIR), to estimate their eligibility for quantitative assessment of Crohn\u2019s disease activity in children and adults. Methods: In inflamed terminal ileum segments (n = 32 in adults, n = 46 in children), Magnetic Resonance Index of Activity (MaRIA) was calculated, ADC values of both DWI techniques were measured, and the corresponding Clermont scores calculated. ADC values of both DWI techniques were compared between both and within each patient group, assessing their mutual correlation. Correlations between MaRIA and the corresponding ADC values, and Clermont scores based on both DWI techniques were estimated. Results: No correlation between ADC of DWISPIR and DWISTIR was observed (rho = 0.27, p = 0.13 in adults, rho = 0.20, p = 0.17 in children). The correlation between MaRIA and Clermont scores was strong in both techniques\u2014in SPIR, rho = 0.93; p &lt; 0.0005 in adults, rho = 0.98, p &lt; 0.0005 in children, and, in STIR, rho = 0.89; p &lt; 0.0005 in adults, rho = 0.95, p &lt; 0.0005 in children. The correlation between ADC and MaRIA was moderate negative for DWISTIR (rho = 0.93, p &lt; 0.0005 in adults, rho = 0.95, p &lt; 0.0005 in children), but, in DWISTIR, no correlation between ADC and MaRIA score was observed in adults (rho = \u22120.001, p = 0.99), whereas children presented low negative correlation (rho = \u22120.374, p = 0.01). Conclusions: DWISTIR is not suitable for quantitative assessment of Crohn\u2019s disease activity both in children and adult patients.<\/jats:p>","DOI":"10.3390\/diagnostics10060347","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T08:27:48Z","timestamp":1590654468000},"page":"347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison between Diffusion-Weighted Sequences with Selective and Non-Selective Fat Suppression in the Evaluation of Crohn\u2019s Disease Activity: Are They Equally Useful?"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-7568","authenticated-orcid":false,"given":"Ilze","family":"Apine","sequence":"first","affiliation":[{"name":"Children Clinical University Hospital of Riga, LV 1004 Riga, Latvia"},{"name":"Department of Radiology, Riga Stradin\u2019s University, LV 1004 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinis","family":"Pitura","sequence":"additional","affiliation":[{"name":"Department of Radiology, Riga Stradin\u2019s University, LV 1004 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivanda","family":"Franckevica","sequence":"additional","affiliation":[{"name":"Children Clinical University Hospital of Riga, LV 1004 Riga, Latvia"},{"name":"Department of Pathology, Riga Stradin\u2019s University, LV 1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-1090","authenticated-orcid":false,"given":"Juris","family":"Pokrotnieks","sequence":"additional","affiliation":[{"name":"Department of Internal Diseases, Riga Stradin\u2019s University, LV 1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaida","family":"Krumina","sequence":"additional","affiliation":[{"name":"Department of Radiology, Riga Stradin\u2019s University, LV 1004 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Cochrane Database of Systematic Reviews MRI scoring indices for evaluation of disease activity and severity in Crohn \u2019 s disease (Methodology Protocol)","volume":"4","author":"Dulai","year":"2015","journal-title":"Cochrane Database Syst. 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