{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:53:51Z","timestamp":1760237631720,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (18F) chloride (18F-FCH) is an analog of choline in which a hydrogen atom has been replaced by fluorine (18F). After crossing the cell membrane by a carrier-mediated mechanism, choline is phosphorylated by choline kinase to produce phosphorylcholine. 18F-FCH positron emission tomography\u2013computed tomography (PET\/CT) is widely used to stage and restage patients affected by prostate cancer with good sensitivity. 18F-FCH PET\/CT showed disease progression with the onset of multiple skull lesions. Numerous suspicious dural hypermetabolic lesions indicating neoplastic involvement were detected along the fronto-parietal convexities, in the left fronto-orbital region and right lateral wall of the orbit, concerning for metastases in these regions. A contrast-enhanced computed tomography (CECT) scan was performed which showed corresponding enhancing tissue which correlated with the PET findings. The final imaging diagnosis was osteo-dural metastases from prostate cancer associated with poor outcome. Awareness of this pattern of metastases may be of clinical relevance in order to avoid unnecessary invasive diagnostic procedures in groups of patients with a dismal prognosis.<\/jats:p>","DOI":"10.3390\/diagnostics10060385","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T04:19:39Z","timestamp":1591676379000},"page":"385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dural Metastases of Advanced Prostate Cancer Detected by 18F-Fluorocholine"],"prefix":"10.3390","volume":"10","author":[{"given":"Mauro","family":"Morassi","sequence":"first","affiliation":[{"name":"Division of Radiology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattia","family":"Bonacina","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Bn\u00e0","sequence":"additional","affiliation":[{"name":"Division of Radiology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Zaniboni","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4898-7647","authenticated-orcid":false,"given":"Giordano","family":"Savelli","sequence":"additional","affiliation":[{"name":"Division of Nuclear Medicine, Fondazione Poliambulanza Istituto Ospedaliero, 25124 Brescia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Nzokou, A., Magro, E., Guilbert, F., Fournier, J.Y., and Bojanowski, M.W. (2015). Subdural metastasis prostate cancer. J. Neurol. Surg. Rep., 123\u2013127.","DOI":"10.1055\/s-0035-1549224"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ganau, M., Gallinaro, P., Cebula, H., Scibilia, A., Todeschi, J., Gubian, A., Nannavecchia, B., Signorelli, F., Pop, R., and Coca, H.-A. (2019). Intracranial Metastases from Prostate Carcinoma: Classification, Management, and Prognostication. World Neurosurg.","DOI":"10.1016\/j.wneu.2019.10.125"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cncr.11522","article-title":"Brain metastasis from prostate carcinoma: The M.D. Anderson Cancer Center experience","volume":"98","author":"Bobustuc","year":"2003","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1053\/hp.2000.6698","article-title":"Metastatic patterns of prostate cancer: An autopsy study of 1589 patients","volume":"31","author":"Bubendorf","year":"2000","journal-title":"Hum. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijscr.2015.08.018","article-title":"Prostate carcinoma mimicking a sphenoid wing meningioma","volume":"15","author":"Bradley","year":"2015","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1552-6569.2012.00767.x","article-title":"Brain Metastases from Prostate Cancer: An 11-Year Analysis in the MRI Era with Emphasis on Imaging Characteristics, Incidence, and Prognosis","volume":"24","author":"Hatzoglou","year":"2014","journal-title":"J. Neuroimaging"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1002\/cncr.24203","article-title":"Intracranial dural metastases","volume":"115","author":"Nayak","year":"2009","journal-title":"Cancer"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/ccr3.2587","article-title":"Three cases of brain metastasis from castration-resistant prostate cancer","volume":"8","author":"Shida","year":"2019","journal-title":"Clin. Case Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000343558","article-title":"Dural Metastases in Advanced Prostate Cancer: A Case Report and Review of the Literature","volume":"7","author":"Weiner","year":"2014","journal-title":"Curr. 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