{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:14:17Z","timestamp":1761560057027,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["RD16\/0008\/0012"],"award-info":[{"award-number":["RD16\/0008\/0012"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["RYC-2016-20471"],"award-info":[{"award-number":["RYC-2016-20471"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Keratoconus is an ectatic disorder that is presently considered one of the most prevalent reasons for keratoplasty. Corneal collagen crosslinking (CXL) is the only proven treatment option available that is capable of halting the progression of the disease by stabilizing the cone in 90% of cases, and by also reducing refractive error and maximal keratometry. This study assesses, by means of a 3D morphogeometric analysis procedure developed by our research team, the corneal structure changes that occur immediately after CXL treatment and during a 6 month follow-up period. A total of 19 eyes from 19 patients diagnosed with keratoconus who underwent CXL were included, and several variables derived from the morphogeometric analysis were calculated and evaluated for the pre-operative, 3 month postoperative, and 6 month postoperative states. Significant reductions were detected in central corneal thickness and corneal spherical-like root mean square (RMS) 3 months after surgery, with non-significant regression of the effect afterward. Significant reductions in the total corneal area\/volume were found, with some levels of regression after 6 months in certain volumetric parameters. In conclusion, the eyes with higher values for morphogeometric parameters\u2014posterior apex deviation (PAD), anterior minimum thickness point deviation (AMTPD), and posterior minimum thickness point deviation (PMTPD)\u2014seemed more likely to undergo aberrometric improvement as a result of CXL surgery.<\/jats:p>","DOI":"10.3390\/diagnostics10060397","type":"journal-article","created":{"date-parts":[[2020,6,12]],"date-time":"2020-06-12T05:02:24Z","timestamp":1591938144000},"page":"397","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Changes in the 3D Corneal Structure and Morphogeometric Properties in Keratoconus after Corneal Collagen Crosslinking"],"prefix":"10.3390","volume":"10","author":[{"given":"Ram\u00f3n","family":"Alifa","sequence":"first","affiliation":[{"name":"Doctorate Program in Industrial Technologies, International School of Doctorate, Technical University of Cartagena, 30202 Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1546-4807","authenticated-orcid":false,"given":"David","family":"Pi\u00f1ero","sequence":"additional","affiliation":[{"name":"Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1329-5093","authenticated-orcid":false,"given":"Jos\u00e9","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Department of Structures, Construction and Graphical Expression, Technical University of Cartagena, 30202 Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-3366","authenticated-orcid":false,"given":"Jorge","family":"Ali\u00f3 del Barrio","sequence":"additional","affiliation":[{"name":"Department of Research and Development, VISSUM, 03016 Alicante, Spain"},{"name":"Cornea, Cataract and Refractive Surgery Department, VISSUM, 03016 Alicante, Spain"},{"name":"Division of Ophthalmology, Department of Pathology and Surgery, Faculty of Medicine, Miguel Hern\u00e1ndez University, 03202 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8391-0688","authenticated-orcid":false,"given":"Francisco","family":"Cavas","sequence":"additional","affiliation":[{"name":"Department of Structures, Construction and Graphical Expression, Technical University of Cartagena, 30202 Cartagena, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge L.","family":"Ali\u00f3","sequence":"additional","affiliation":[{"name":"Department of Research and Development, VISSUM, 03016 Alicante, Spain"},{"name":"Cornea, Cataract and Refractive Surgery Department, VISSUM, 03016 Alicante, Spain"},{"name":"Division of Ophthalmology, Department of Pathology and Surgery, Faculty of Medicine, Miguel Hern\u00e1ndez University, 03202 Alicante, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"ref_1","first-page":"2","article-title":"Corneal surgery in keratoconus: Which type, which technique, which outcomes?","volume":"3","year":"2016","journal-title":"Eye Vis. (Lond.)"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/bjo.2010.185868","article-title":"Management of keratoconus: Current scenario","volume":"95","author":"Jhanji","year":"2010","journal-title":"Br. J. Ophthalmol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ophtha.2013.12.017","article-title":"A Comparison of Lamellar and Penetrating Keratoplasty Outcomes","volume":"121","author":"Coster","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1016\/j.ajo.2015.08.023","article-title":"Corneal Cross-linking to Halt the Progression of Keratoconus and Corneal Ectasia: Seven-Year Follow-up","volume":"160","author":"Patel","year":"2015","journal-title":"Am. J. Ophthalmol."},{"key":"ref_5","first-page":"4671","article-title":"Conservative therapy of keratoconus by enhancement of collagen cross-links","volume":"37","author":"Seiler","year":"1996","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"O\u2019Brart, D. (2016). Corneal Collagen Cross-Linking for Corneal Ectasias. Keratoconus, Springer International Publishing.","DOI":"10.1007\/978-3-319-43881-8_19"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.jcrs.2017.07.021","article-title":"New perspectives on the detection and progression of keratoconus","volume":"43","year":"2017","journal-title":"J. Cataract Refract. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Cavas-Mart\u00ednez, F., Fern\u00e1ndez-Pacheco, D.G., De la Cruz-S\u00e1nchez, E., Nieto Mart\u00ednez, J., Fern\u00e1ndez Ca\u00f1avate, F.J., Vega-Estrada, A., Plaza-Puche, A.B., and Ali\u00f3, J.L. (2014). Geometrical custom modeling of human cornea in vivo and its use for the diagnosis of corneal ectasia. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0110249"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jare.2020.03.012","article-title":"Morphogeometric analysis for characterization of keratoconus considering the spatial localization and projection of apex and minimum corneal thickness point","volume":"24","author":"Cavas","year":"2020","journal-title":"J. Adv. Res"},{"key":"ref_10","first-page":"8731626","article-title":"Assessment of the Association between In Vivo Corneal Morphogeometrical Changes and Keratoconus Eyes with Severe Visual Limitation","volume":"2019","author":"Cavas","year":"2019","journal-title":"J. Ophthalmol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1186\/s12938-018-0564-7","article-title":"Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus","volume":"17","author":"Parras","year":"2018","journal-title":"Biomed. Eng. Online"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"15837","DOI":"10.1038\/s41598-017-16145-3","article-title":"Keratoconus Detection Based on a New Corneal Volumetric Analysis","volume":"7","author":"Bataille","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Cavas-Mart\u00ednez, F., Bataille, L., Fern\u00e1ndez-Pacheco, D.G., Ca\u00f1avate, F.J.F., and Ali\u00f3, J.L. (2017). A new approach to keratoconus detection based on corneal morphogeometric analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0184569"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Vel\u00e1zquez, J.S., Cavas, F., Bolar\u00edn, J.M., and Ali\u00f3, J.L. (2020). 3D Printed Personalized Corneal Models as a Tool for Improving Patient\u2019s Knowledge of an Asymmetric Disease. Symmetry, 12.","DOI":"10.3390\/sym12010151"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Cavas-Mart\u00ednez, F., Pi\u00f1ero, D., Fern\u00e1ndez-Pacheco, D., Mira, J., Ca\u00f1avate, F., and Ali\u00f3, J. (2018). Assessment of Pattern and Shape Symmetry of Bilateral Normal Corneas by Scheimpflug Technology. Symmetry, 10.","DOI":"10.3390\/sym10100453"},{"key":"ref_16","first-page":"1526","article-title":"Keratoconus corneal architecture after riboflavin\/ultraviolet A cross-linking: Ultrastructural studies","volume":"19","author":"Akhtar","year":"2013","journal-title":"Mol. Vis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s10103-012-1237-6","article-title":"Structural response of human corneal and scleral tissues to collagen cross-linking treatment with riboflavin and ultraviolet A light","volume":"28","author":"Choi","year":"2012","journal-title":"Lasers Med. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.ophtha.2013.09.014","article-title":"In Vivo Confocal Microscopy Analyses of Corneal Microstructural Changes in a Prospective Study of Collagen Cross-linking in Keratoconus","volume":"121","author":"Jordan","year":"2014","journal-title":"Ophthalmology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/ICO.0000000000001029","article-title":"Morphology of the Corneal Limbus Following Standard and Accelerated Corneal Collagen Cross-Linking (9 mW\/cm2) for Keratoconus","volume":"36","author":"Bayraktutar","year":"2017","journal-title":"Cornea"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.exer.2018.08.009","article-title":"Collagen fiber crimping following in vivo UVA-induced corneal crosslinking","volume":"177","author":"Bradford","year":"2018","journal-title":"Exp. Eye Res."},{"key":"ref_21","first-page":"809","article-title":"Morphologische Hornhautver\u00e4nderungen nach Crosslinking bei Keratokonus","volume":"235","author":"Kohlhaas","year":"2017","journal-title":"Klin. Mon. F\u00fcr Augenheilkd."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2008.09.048","article-title":"Refractive, Topographic, Tomographic, and Aberrometric Analysis of Keratoconic Eyes Undergoing Corneal Cross-Linking","volume":"116","author":"Vinciguerra","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1001\/archophthalmol.2009.205","article-title":"Intraoperative and Postoperative Effects of Corneal Collagen Cross-linking on Progressive Keratoconus","volume":"127","author":"Vinciguerra","year":"2009","journal-title":"Arch. Ophthalmol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1755-3768.2010.01890.x","article-title":"Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus","volume":"90","author":"Mazzotta","year":"2010","journal-title":"Acta Ophthalmol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"793","DOI":"10.5301\/ejo.5000313","article-title":"Scheimpflug Parameters after Corneal Collagen Crosslinking for Keratoconus","volume":"23","author":"Toprak","year":"2013","journal-title":"Eur. J. Ophthalmol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.clae.2014.07.007","article-title":"Trans epithelial corneal collagen crosslinking for progressive keratoconus: 6 months follow up","volume":"37","author":"Capasso","year":"2014","journal-title":"Contact Lens Anterior Eye"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/ICO.0000000000000434","article-title":"Relationship of Structural Characteristics to Biomechanical Profile in Normal, Keratoconic, and Crosslinked Eyes","volume":"34","author":"Viswanathan","year":"2015","journal-title":"Cornea"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4103\/0974-9233.151877","article-title":"Changes in corneal topography and biomechanical properties after collagen cross linking for keratoconus: 1-year results","volume":"22","author":"Sedaghat","year":"2015","journal-title":"Middle East Afr. J. Ophthalmol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.optom.2014.05.006","article-title":"Long-term results of corneal collagen crosslinking for progressive keratoconus","volume":"8","author":"Capasso","year":"2015","journal-title":"J. Optom."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3928\/01913913-20160831-01","article-title":"Visual, Topographic, and Pachymetric Effects of Pediatric Corneal Collagen Cross-linking","volume":"54","author":"Toprak","year":"2016","journal-title":"J. Pediatric Ophthalmol. Strabismus"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3928\/1081597X-20180123-01","article-title":"The 7-Year Outcomes of Epithelium-Off Corneal Cross-linking in Progressive Keratoconus","volume":"34","author":"Lolah","year":"2018","journal-title":"J. Refract. Surg."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/6\/397\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:37:55Z","timestamp":1760175475000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/6\/397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":31,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["diagnostics10060397"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10060397","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2020,6,11]]}}}