{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T03:22:34Z","timestamp":1775013754241,"version":"3.50.1"},"reference-count":67,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T00:00:00Z","timestamp":1596067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015082","name":"Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir","doi-asserted-by":"publisher","award":["2018-158-002 and 2020-189-001"],"award-info":[{"award-number":["2018-158-002 and 2020-189-001"]}],"id":[{"id":"10.13039\/501100015082","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: The diagnosis of sarcopenia through clinical assessment has some limitations. The literature advises studies that include objective markers along with clinical assessment in order to improve the sensitivity and specificity of current diagnostic criteria. The decrease of muscle quality precedes the loss of quantity, so we studied the role magnetic resonance imaging biomarkers as indicators of the quantity and quality of muscle in sarcopenia patients. Methods: a cross-sectional analysis was performed to analyze what MR-derived imaging parameters correlate better with sarcopenia diagnostic criteria in women of 70 years of age and over (independent walking and community-dwelling women who were sarcopenic in accordance with EWGSOP criteria with muscle mass adjusted to Spanish population were chosen). Results: The study included 26 women; 81 \u00b1 8 years old. A strong correlation was obtained between cineanthropometric variables (BMI; thigh perimeter and fat mass) and imaging biomarkers (muscle\/fat ratio, fatty infiltration, muscle T2*, water diffusion coefficient, and proton density fat fraction) with coefficients around 0.7 (absolute value). Conclusions: Knowing the correlation of clinical parameters and imaging-derived muscle quality indicators can help to identify older women at risk of developing sarcopenia at an early stage. This may allow taking preventive actions to decrease disability, morbidity, and mortality in sarcopenia patients.<\/jats:p>","DOI":"10.3390\/diagnostics10080534","type":"journal-article","created":{"date-parts":[[2020,7,30]],"date-time":"2020-07-30T12:15:38Z","timestamp":1596111338000},"page":"534","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The Role of Imaging Biomarkers in the Assessment of Sarcopenia"],"prefix":"10.3390","volume":"10","author":[{"given":"Roberto","family":"Sanz-Requena","sequence":"first","affiliation":[{"name":"Radiology Department, Hospital Quironsalud Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1949-3290","authenticated-orcid":false,"given":"Francisco Miguel","family":"Mart\u00ednez-Arnau","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Universitat de Valencia, 46010 Valencia, Spain"},{"name":"Frailty and Cognitive Impairment Research Group (FROG), University of Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Pablos-Monz\u00f3","sequence":"additional","affiliation":[{"name":"Faculty of Physical Activity and Sport Sciences, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, 46900 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-7832","authenticated-orcid":false,"given":"Cristina","family":"Flor-Rufino","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Universitat de Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4345-5251","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Barrachina-Igual","sequence":"additional","affiliation":[{"name":"Doctoral School, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, 46002 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graci\u00e1n","family":"Garc\u00eda-Mart\u00ed","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Quironsalud Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8234-010X","authenticated-orcid":false,"given":"Luis","family":"Mart\u00ed-Bonmat\u00ed","sequence":"additional","affiliation":[{"name":"Radiology Department, Hospital Quironsalud Valencia, 46010 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-9792","authenticated-orcid":false,"given":"Pilar","family":"P\u00e9rez-Ros","sequence":"additional","affiliation":[{"name":"Nursing Department, Universidad Cat\u00f3lica de Valencia San Vicente M\u00e1rtir, 46007 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: Revised European consensus on definition and diagnosis","volume":"48","author":"Bahat","year":"2019","journal-title":"Age Ageing"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Baeyens","year":"2010","journal-title":"Age Ageing"},{"key":"ref_3","first-page":"87","article-title":"The Need for Standardized Assessment of Muscle Quality in Skeletal Muscle Function Deficit and Other Aging-Related Muscle Dysfunctions: A Symposium Report","volume":"8","author":"Miljkovic","year":"2017","journal-title":"Front. 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