{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:11:14Z","timestamp":1760238674225,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T00:00:00Z","timestamp":1598832000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All patients were genotyped for sequence variations in F5, F2, F11, MTHFR, SERPINE-1, CYP4V2, SELE, GP6, angiotensinogen (AGT) and fibrinogen gamma (FGG) genes and followed up until delivery. Results. There were no differences between groups regarding selected sequence variations in any of these genes. The co-occurrence of several polymorphisms in the same patient was also not related to the blood flow patterns in the uterine arteries. Conclusions. Although we found certain trends of genetic polymorphisms being related to preeclampsia and fetal growth, we failed to find an association between clotting gene polymorphisms, single or in combination, with the abnormal uterine flow in the first trimester.<\/jats:p>","DOI":"10.3390\/diagnostics10090654","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T08:11:19Z","timestamp":1598861479000},"page":"654","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Correlation Between Abnormal Uterine Artery Flow in the First Trimester and Genetic Thrombophilic Alteration: A Prospective Case-Controlled Pilot Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Natalija","family":"Vedmedovska","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Bokucava","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Riga Stradins University, LV-1007 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6362-1187","authenticated-orcid":false,"given":"Anda","family":"Kivite-Urtane","sequence":"additional","affiliation":[{"name":"Department of Public Health and Epidemiology, Riga Stradins University, LV-1010 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9368-5210","authenticated-orcid":false,"given":"Vita","family":"Rovite","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liene","family":"Zake-Nikitina","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janis","family":"Klovins","sequence":"additional","affiliation":[{"name":"Latvian Biomedical Research and Study Centre, LV-1067 Riga, Latvia"},{"name":"Department of Medicine, University of Latvia, LV-1050 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Fodina","sequence":"additional","affiliation":[{"name":"Reproductive Clinic IVF RIGA, LV-1010 Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9890-6254","authenticated-orcid":false,"given":"Gilbert G. G.","family":"Donders","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Antwerp, 2550 Antwerp-Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3349\/ymj.2016.57.5.1230","article-title":"The Impact of Inherited Thrombophilia Types and Low Molecular Weight Heparin Treatment on Pregnancy Complications in Women with Previous Adverse Outcome","volume":"57","author":"Aracic","year":"2016","journal-title":"Yonsei Med. J."},{"unstructured":"Knight, M., Nair, M., Tuffnell, D., Kenyon, S., Shakespeare, J., Brocklehurst, P., and Kurinczuk, J.J. (2016). On Behalf of MBRRACE-UK. 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