{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:50:42Z","timestamp":1762321842387,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objectives: The distribution of venous pathology in stasis leg ulcers is unclear. The main reason for this uncertainty is the lack of objective diagnostic tools. To fill this gap, we assessed the effectiveness of triggered angiography non-contrast-enhanced (TRANCE)-magnetic resonance imaging (MRI) in determining the venous status of patients with stasis leg ulcers. Methods: This prospective observational study included the data of 23 patients with stasis leg ulcers who underwent TRANCE-MRI between April 2017 and May 2020; the data were retrospectively analyzed. TRANCE MRI utilizes differences in vascular signal intensity during the cardiac cycle for subsequent image subtraction, providing not only a venogram but also an arteriogram without the use of contrast agents or radiation. Results: TRANCE MRI revealed that the stasis leg ulcers of nine of the 23 patients could be attributed to valvular insufficiency and venous occlusion (including deep venous thrombosis [DVT], May\u2013Thurner syndrome, and other external compression). Moreover, TRANCE MRI demonstrated no venous pathology in five patients (21.7%). We analyzed TRANCE MRI hemodynamic parameters, namely stroke volume, forward flow volume, backward flow volume, regurgitant fraction, absolute volume, mean flux, stroke distance, and mean velocity, in the external iliac vein, femoral vein, popliteal vein, and great saphenous vein (GSV) in three of the patients with valvular insufficiency and three of those with venous occlusion. We found that the mean velocity and stroke volume in the GSV was higher than that in the popliteal vein in all patients with venous valvular insufficiency. Conclusions: Stasis leg ulcers may have no underlying venous disease and could be confirmed by TRANCE-MRI. TRANCE MRI has good Interrater reliability between Duplex study in greater saphenous venous insufficiency. It also potentially surpasses existing diagnostic modalities in terms of distinguishable hemodynamic figures. Accordingly, TRANCE-MRI is a safe and useful tool for examining stasis leg ulcers and is extensively applied currently.<\/jats:p>","DOI":"10.3390\/diagnostics10090707","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T20:47:48Z","timestamp":1600375668000},"page":"707","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Stasis Leg Ulcers: Venous System Revises by Triggered Angiography Non-Contrast-Enhanced Sequence Magnetic Resonance Imaging"],"prefix":"10.3390","volume":"10","author":[{"given":"Chien-Wei","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang-Gung University, Chiayi 61363, Taiwan"},{"name":"Department of Cardiovascular Surgery, Wound and Vascular Center, 6 West Section, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Hsi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wound and Vascular Center, 6 West Section, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan"},{"name":"Division of Thoracic and Cardiovascular Surgery, Chiayi Chang Gung Memorial Hospital, College of Medicine Chia-Yi and Chang Gung University, Taoyuan 61363, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Yi","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang-Gung University, Chiayi 61363, Taiwan"},{"name":"Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan 71150, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Ming","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Wound and Vascular Center, 6 West Section, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8653-2571","authenticated-orcid":false,"given":"Bor-Shyh","family":"Lin","sequence":"additional","affiliation":[{"name":"Institute of Imaging and Biomedical Photonics, National Chiao Tung University, Tainan 71150, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-2207","authenticated-orcid":false,"given":"Yao-Kuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Chang Gung Memorial Hospital, Chang-Gung University, Chiayi 61363, Taiwan"},{"name":"Department of Cardiovascular Surgery, Wound and Vascular Center, 6 West Section, Chang Gung Memorial Hospital, Chia-Yi 61363, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"ref_1","first-page":"298","article-title":"Venous Ulcers: Diagnosis and Treatment","volume":"100","author":"Gan","year":"2019","journal-title":"Am. Fam. Physician"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-0038-1676362","article-title":"Differentiating Lower Extremity Wounds: Arterial, Venous, Neurotrophic","volume":"35","author":"Star","year":"2018","journal-title":"Semin. Interv. Radiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"k3115","DOI":"10.1136\/bmj.k3115","article-title":"Diagnosis and management of venous leg ulcers","volume":"362","author":"Lim","year":"2018","journal-title":"BMJ"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1148\/radiology.154.2.3966131","article-title":"Blood flow: Magnetic resonance imaging","volume":"154","author":"Bradley","year":"1985","journal-title":"Radiology"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chen, C.W., Tseng, Y.H., Lin, C.C., Kao, C.C., Wong, M.Y., Lin, B.S., and Huang, Y.K. (2020). Novel Diagnostic Options without Contrast Media or Radiation: Triggered Angiography Non-Contrast-Enhanced Sequence Magnetic Resonance Imaging in Treating Different Leg Venous Diseases. Diagnostics, 10.","DOI":"10.3390\/diagnostics10060355"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Huang, Y.K., Tseng, Y.H., Lin, C.H., Tsai, Y.H., Hsu, Y.C., Wang, S.C., and Chen, C.W. (2019). Evaluation of venous pathology of the lower extremities with triggered angiography non-contrast-enhanced magnetic resonance imaging. BMC Med. Imaging, 19.","DOI":"10.1186\/s12880-019-0395-4"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1177\/0267659118791682","article-title":"Chronic venous insufficiency: A new concept to understand pathophysiology at the microvascular level\u2014A pilot study","volume":"34","author":"Mutlak","year":"2019","journal-title":"Perfusion"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1524-475X.2007.00283.x","article-title":"Why chronic wounds will not heal: A novel hypothesis","volume":"16","author":"Bjarnsholt","year":"2008","journal-title":"Wound Repair Regen."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Morilla-Herrera, J.C., Morales-Asencio, J.M., Gomez-Gonzalez, A.J., Diez-De Los Rios, A., Lupianez-Perez, I., Acosta-Andrade, C., Aranda-Gallardo, M., Moya-Suarez, A.B., Kaknani-Uttumchandani, S., and Garcia-Mayor, S. (2020). Effectiveness of a hydrophobic dressing for microorganisms\u2019 colonization of vascular ulcers: Protocol for a randomized controlled trial (CUCO-UV Study). J. Adv. Nurs.","DOI":"10.1111\/jan.14412"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/iwj.13333","article-title":"Clinical and economic burden of wound care in the tropics: A 5-year institutional population health review","volume":"17","author":"Lo","year":"2020","journal-title":"Int. Wound J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/jcu.20236","article-title":"Current approaches and controversial issues in the diagnosis of deep vein thrombosis via duplex Doppler ultrasound","volume":"34","author":"Gaitini","year":"2006","journal-title":"J. Clin. Ultrasound"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"S39","DOI":"10.1259\/bjr\/17627958","article-title":"Multislice CT pulmonary angiography and CT venography","volume":"77","author":"Reid","year":"2004","journal-title":"Br. J. Radiol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3400\/avd.oa.14-00068","article-title":"MR Venography for the Assessment of Deep Vein Thrombosis in Lower Extremities with Varicose Veins","volume":"7","author":"Tamura","year":"2014","journal-title":"Ann. Vasc. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1148\/radiology.215.2.r00ap27421","article-title":"Pelvic and lower extremity veins: Contrast-enhanced three-dimensional MR venography with a dedicated vascular coil-initial experience","volume":"215","author":"Ruehm","year":"2000","journal-title":"Radiology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s13760-017-0835-2","article-title":"Time-of-flight MR angiography in cerebral venous sinus thrombosis","volume":"117","author":"Renard","year":"2017","journal-title":"Acta Neurol. Belg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1148\/radiology.187.3.8497608","article-title":"Atherosclerotic occlusive disease of the lower extremity: Prospective evaluation with two-dimensional time-of-flight MR angiography","volume":"187","author":"Yucel","year":"1993","journal-title":"Radiology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1515\/bmt-2013-0113","article-title":"Non-invasive ECG-triggered 2D TOF MR angiography of the pelvic and leg arteries in an open 1.0-tesla high-field MRI system in comparison to conventional DSA","volume":"59","author":"Suttmeyer","year":"2014","journal-title":"Biomed. Tech. (Berl.)"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.clinimag.2012.01.016","article-title":"Non-contrast-enhanced MR venography of the upper limb: A comparative study of acquisitions with fresh blood imaging vs. time-of-flight methods","volume":"36","author":"Harigai","year":"2012","journal-title":"Clin. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004728-199901000-00002","article-title":"Lower extremity occlusive disease: Diagnostic imaging with a combination of cardiac-gated 2D phase-contrast and cardiac-gated 2D time-of-flight MRA","volume":"23","author":"Steffens","year":"1999","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ejrad.2010.04.033","article-title":"Direct contrast-enhanced MR venography in the diagnosis of May-Thurner syndrome","volume":"80","author":"Gurel","year":"2011","journal-title":"Eur. J. Radiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s003300000586","article-title":"Direct contrast-enhanced 3D MR venography","volume":"11","author":"Ruehm","year":"2001","journal-title":"Eur. Radiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mri.2020.02.012","article-title":"Incidence of nephrogenic systemic fibrosis after administration of gadoteric acid in patients on renal replacement treatment","volume":"70","author":"Alfano","year":"2020","journal-title":"Magn. Reson. Imaging"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.carj.2019.04.001","article-title":"Updated Clinical Practice Guideline on Use of Gadolinium-Based Contrast Agents in Kidney Disease Issued by the Canadian Association of Radiologists","volume":"70","author":"Schieda","year":"2019","journal-title":"Can. Assoc. Radiol. J."},{"key":"ref_24","first-page":"19","article-title":"Qualitative phase contrast MRA in the normal and abnormal circle of Willis","volume":"14","author":"Ross","year":"1993","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_25","first-page":"68","article-title":"Quantitative phase-contrast MRI study of cerebrospinal fluid flow: A method for identifying patients with normal-pressure hydrocephalus","volume":"29","author":"Florez","year":"2014","journal-title":"Neurologia"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00330-011-2132-4","article-title":"ECG-triggered non-contrast-enhanced MR angiography (TRANCE) versus digital subtraction angiography (DSA) in patients with peripheral arterial occlusive disease of the lower extremities","volume":"21","author":"Gutzeit","year":"2011","journal-title":"Eur. Radiol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/bmt-2014-0181","article-title":"Initial experience with imaging of the lower extremity arteries in an open 1.0 Tesla MRI system using the triggered angiography non-contrast-enhanced sequence (TRANCE) compared to digital subtraction angiography (DSA)","volume":"61","author":"Suttmeyer","year":"2016","journal-title":"Biomed. Tech. (Berl.)"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ejrad.2010.09.028","article-title":"Triggered non-contrast enhanced MR angiography of peripheral arteries: Optimization of systolic and diastolic time delays for electrocardiographic triggering","volume":"80","author":"Radlbauer","year":"2011","journal-title":"Eur. J. Radiol."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Ohno, N., Miyati, T., Noda, T., Alperin, N., Hamaguchi, T., Ohno, M., Matsushita, T., Mase, M., Gabata, T., and Kobayashi, S. (2020). Fast Phase-Contrast Cine MRI for Assessing Intracranial Hemodynamics and Cerebrospinal Fluid Dynamics. Diagnostics, 10.","DOI":"10.3390\/diagnostics10040241"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/9\/707\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:10:57Z","timestamp":1760177457000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/9\/707"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,17]]},"references-count":29,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["diagnostics10090707"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10090707","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2020,9,17]]}}}