{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:15:49Z","timestamp":1779376549978,"version":"3.53.1"},"reference-count":14,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Primary cardiac tumors are extremely rare, with an incidence of 0.001\u20130.03%. Twenty-five percent of these tumors are malignant, with sarcomas accounting for approximately 95%. Cardiac intimal sarcoma is the least reported subtype of primary cardiac sarcoma. These endocardial mesenchymal tumors most often arise from great arterial vessels, and are rarely located in the heart. They often present with an aggressive clinical course and have a poor prognosis, with surgical resection with achievement of free margins being the mainstay of treatment. This emphasizes the importance of an early, correct diagnosis and timely intervention. We report a 60-year-old Caucasian male with several former cardiac surgical procedures due to congenital aortic stenosis, presenting with functional mitral stenosis\/insufficiency and left ventricular outflow tract obstruction (LVOTO) due to massive masses in the left ventricle and atrium of the heart. Hybrid imaging with 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography\/computed tomography (2-[18F]FDG PET\/CT) was performed prior to surgery to characterize the intracardiac masses and estimate tumor burden, as well as to identify a potential extracardiac primary malignancy.<\/jats:p>","DOI":"10.3390\/diagnostics10090718","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T07:06:09Z","timestamp":1600499169000},"page":"718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Primary Cardiac Intimal Sarcoma Visualized on 2-[18F]FDG PET\/CT"],"prefix":"10.3390","volume":"10","author":[{"given":"Kim Francis","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid Sharghi","family":"Someh","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Loft","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane Maestri","family":"Brittain","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology, Nuclear Medicine &amp; PET, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1470-2045(05)70093-0","article-title":"Cardiac Tumours: Diagnosis and Management","volume":"6","author":"Butany","year":"2005","journal-title":"Lancet Oncol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0002-9149(97)89149-7","article-title":"Frequency of Primary Tumors of the Heart","volume":"77","author":"Reynen","year":"1996","journal-title":"Am. J. Cardiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/PAS.0000000000000184","article-title":"Intimal sarcoma is the most frequent primary cardiac sarcoma: Clinicopathologic and molecular retrospective analysis of 100 primary cardiac sarcomas","volume":"38","author":"Neuville","year":"2014","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"307","DOI":"10.14740\/cr748w","article-title":"Functional Mitral Stenosis: Imposture of Primary Cardiac Intimal Sarcoma","volume":"9","author":"Vinod","year":"2018","journal-title":"Cardiol. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"461815","DOI":"10.1155\/2013\/461815","article-title":"Primary intimal (spindle cell) sarcoma of the heart: A case report and review of the literature","volume":"2013","author":"Ibrahim","year":"2013","journal-title":"Case Rep. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1758835918793569","DOI":"10.1177\/1758835918793569","article-title":"(18)F-FDG-PET\/CT imaging in cardiac tumors: Illustrative clinical cases and review of the literature","volume":"10","author":"Saponara","year":"2018","journal-title":"Ther. Adv. Med. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1007\/s12410-014-9281-1","article-title":"Cardiac Masses on Cardiac CT: A Review","volume":"7","author":"Kassop","year":"2014","journal-title":"Curr. Cardiovasc. Imaging Rep."},{"key":"ref_8","first-page":"255","article-title":"Integrated 18F-FDG PET\/MR imaging in the assessment of cardiac masses: A pilot study","volume":"56","author":"Nensa","year":"2015","journal-title":"J. Nucl. Med. Off. Publ. Soc. Nucl. Med."},{"key":"ref_9","first-page":"856","article-title":"Differentiation of malignant and benign cardiac tumors using 18F-FDG PET\/CT","volume":"53","author":"Rahbar","year":"2012","journal-title":"J. Nucl. Med. Off. Publ. Soc. Nucl. Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13019-015-0255-4","article-title":"Primary cardiac tumors on the verge of oblivion: A European experience over 15 years","volume":"10","author":"Habertheuer","year":"2015","journal-title":"J. Cardiothorac. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejca.2013.09.012","article-title":"Primary cardiac sarcomas: A retrospective study of the French Sarcoma Group","volume":"50","author":"Isambert","year":"2014","journal-title":"Eur. J. Cancer"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s13569-017-0069-3","article-title":"Two years survival of primary cardiac leiomyosarcoma managed by surgical and adjuvant therapy","volume":"7","author":"Behi","year":"2017","journal-title":"Clin. Sarcoma Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1038\/bjc.1998.733","article-title":"Adjuvant chemotherapy for primary cardiac sarcomas: The IGR experience","volume":"78","author":"Pivot","year":"1998","journal-title":"Br. J. Cancer"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1002\/cncr.23459","article-title":"Malignant primary cardiac tumors: Review of a single institution experience","volume":"112","author":"Simpson","year":"2008","journal-title":"Cancer"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/9\/718\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:11:30Z","timestamp":1760177490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/9\/718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":14,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["diagnostics10090718"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10090718","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}