{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:27:45Z","timestamp":1790972865847,"version":"4.1.0"},"reference-count":90,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Marfan syndrome (MFS) is a heritable systemic connective tissue disease with important cardiovascular involvement, including aortic root dilatation and mitral valve prolapse. Life expectancy in patients with MFS is mainly determined by cardiovascular complications, among which aortic dissection or rupture are most dreaded. In recent years, heart failure and ventricular arrhythmia have drawn attention as extra-aortic cardiovascular manifestations and as additional reported causes of death. Imaging studies have provided data supporting a primary myocardial impairment in the absence of valvular disease or cardiovascular surgery, while studies using ambulatory ECG have demonstrated an increased susceptibility to ventricular arrhythmia. In this paper, current literature was reviewed in order to provide insights in characteristics, pathophysiology and evolution of myocardial function, heart failure and ventricular arrhythmia in MFS.<\/jats:p>","DOI":"10.3390\/diagnostics10100751","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T08:57:32Z","timestamp":1601024252000},"page":"751","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Myocardial Function, Heart Failure and Arrhythmia in Marfan Syndrome: A Systematic Literature Review"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1531-6396","authenticated-orcid":false,"given":"Anthony","family":"Demolder","sequence":"first","affiliation":[{"name":"Centre for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yskert","family":"von Kodolitsch","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, 20251 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3094-7807","authenticated-orcid":false,"given":"Laura","family":"Mui\u00f1o-Mosquera","sequence":"additional","affiliation":[{"name":"Centre for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium"},{"name":"Department of Paediatrics, Division of Paediatric Cardiology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-1507","authenticated-orcid":false,"given":"Julie","family":"De Backer","sequence":"additional","affiliation":[{"name":"Centre for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium"},{"name":"Department of Cardiology, Ghent University Hospital, 9000 Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Von Kodolitsch, Y., De Backer, J., Sch\u00fcler, H., Bannas, P., Behzadi, C., Bernhardt, A.M., Hillebrand, M., Fuisting, B., Sheikhzadeh, S., and Rybczynski, M. 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