{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:20:16Z","timestamp":1784042416250,"version":"3.55.0"},"reference-count":11,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Benign epithelial tumors of the lung are uncommon and can represent a diagnostic challenge. Herein, we describe one such emblematic case. A 59-year-old former smoker male was admitted to the hospital complaining of cough for a long time. A radiological examination showed a centrally excavated mass strictly connected to the visceral pleura. The patient underwent tumorectomy. At gross examination, the tumor was composed of solid and cystic areas containing clear liquid. Histological examination highlighted a sub-pleural encapsulated tumor, with foci of capsular invasion, characterized by a single layer of columnar and cuboidal epithelial cells lining moderately cellular fibro-vascular cores. A wide spectrum of immunohistochemical markers was performed. The final diagnosis was suggestive of a peripheral pulmonary papillary tumor of undetermined malignant potential. At the last follow-up, six years after surgery, no recurrence or metastases were described. Reporting this case, we would like to point out the existence of these rare entities that should be taken into account in the diagnostic process, thus avoiding potential misdiagnosis. Moreover, the presence of capsular invasion should be better investigated in order to reconsider the exact terminology of the tumor and the classification of its malignant potential.<\/jats:p>","DOI":"10.3390\/diagnostics10110906","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T09:09:30Z","timestamp":1604653770000},"page":"906","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Massive Relief: Papillary Adenoma of the Lung in Asymptomatic Former Smoker Patient"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9290-0967","authenticated-orcid":false,"given":"Jelena","family":"Stoj\u0161i\u0107","sequence":"first","affiliation":[{"name":"Department of Thoracic Pathology, Service of Pathology, University Clinical centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"Clinic of Thoracic Surgery, University Clinical Centre of Serbia, Koste Todorovi\u0107a 26, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-3108","authenticated-orcid":false,"given":"Federica","family":"Pezzuto","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic, Vascular Sciences and Public Health, Pathology Section, Medical School, University of Padova, 35121 Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Markovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Thoracic Pathology, Service of Pathology, University Clinical centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,6]]},"reference":[{"key":"ref_1","unstructured":"Travis, W.D., Brambila, E., Burke, A.P., Marx, A., and Nicholson, A.G. (2015). WHO Classification of Tumours of Lung, Pleura, Thymus and Heart."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/LBR.0b013e3182814cfd","article-title":"Pulmonary papillary adenoma: A case report and review of the literature","volume":"20","author":"Cornejo","year":"2013","journal-title":"J. Bronchol Interv Pulmonol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00200662","article-title":"Papillary adenoma of type II pneumocytes might have malignant potential","volume":"428","author":"Mori","year":"1996","journal-title":"Virchows Arch."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s004280050043","article-title":"Peripheral papillary tumor of type-II pneumocytes: A rare neoplasm of undetermined malignant potential","volume":"436","author":"Dessy","year":"2000","journal-title":"Virchows Arch."},{"key":"ref_5","first-page":"792","article-title":"Pulmonary papillary adenoma with malignant transformation: Report of one case and review of the literature","volume":"13","author":"Ma","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2298\/SARH0710569S","article-title":"Pulmonary sclerosing haemangioma\u2014Case report","volume":"135","author":"Percinkovski","year":"2007","journal-title":"Srp. Arh. Celok. Lek."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s00595-009-4220-5","article-title":"Pulmonary sclerosing hemangioma with pleural dissemination: Report of a case","volume":"41","author":"Suzuki","year":"2011","journal-title":"Surg. Today"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.5761\/atcs.cr.10.01553","article-title":"A case of sclerosing hemangioma forming a pedunculated mass","volume":"17","author":"Ichinose","year":"2011","journal-title":"Ann. Thorac. Cardiovasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2298\/SARH0708461S","article-title":"Alveolar adenoma\u2014A rare lung tumour","volume":"135","author":"Percinkovski","year":"2007","journal-title":"Srp. Arh. Celok. Lek."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/(SICI)1097-0142(19960215)77:4<665::AID-CNCR12>3.0.CO;2-Z","article-title":"Atypical adenomatous hyperplasia and adenocarcinoma of the human lung: Their heterology in form and analogy in immunohistochemical characteristics","volume":"77","author":"Mori","year":"1996","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13000-015-0425-7","article-title":"Pulmonary papillary adenoma presenting in central portion: A case report","volume":"10","author":"Lin","year":"2015","journal-title":"Diagn. Pathol."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/11\/906\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:29:59Z","timestamp":1760178599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/11\/906"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,6]]},"references-count":11,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11]]}},"alternative-id":["diagnostics10110906"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10110906","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,6]]}}}