{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:57:16Z","timestamp":1773968236198,"version":"3.50.1"},"reference-count":56,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Chronic pancreatitis (CP) is associated with a risk of pancreatic cancer and is characterized by irreversible morphological changes, fibrosis, calcification, and exocrine and endocrine insufficiency. CP is a progressive disease with a poor prognosis and is typically diagnosed at an advanced stage. The Japan Pancreas Society proposed criteria for early CP in 2009, and their usefulness has been reported. Recently, a mechanism definition was proposed by the International Consensus Guidelines and early CP was defined as a disease state that is not based on disease duration. CP is diagnosed by computed tomography, magnetic resonance imaging, and endoscopic cholangiopancreatography, which can detect calcification and dilation of the pancreatic ducts; however, detecting early CP with these modalities is difficult because subtle changes in early CP occur before established CP or end-stage CP. Endoscopic ultrasonography (EUS) is useful in the diagnosis of early CP because it allows high-resolution, close-up observation of the pancreas. In addition to imaging findings, EUS with elastography enables measurement of the stiffness of the pancreas, an objective diagnostic measure. Understanding the EUS findings of early CP is important because a histological diagnosis is problematic, and other modalities are not capable of detecting subtle changes in early CP.<\/jats:p>","DOI":"10.3390\/diagnostics10121018","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T03:51:16Z","timestamp":1606535476000},"page":"1018","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Endoscopic Ultrasonography Findings of Early and Suspected Early Chronic Pancreatitis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5036-4545","authenticated-orcid":false,"given":"Yusuke","family":"Takasaki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-7765","authenticated-orcid":false,"given":"Shigeto","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7367-0767","authenticated-orcid":false,"given":"Toshio","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mako","family":"Ushio","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ko","family":"Tomishima","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Isayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University of Juntendo, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.pan.2019.11.007","article-title":"A clinically feasible method for the assessment and characterization of pain in patients with chronic pancreatitis","volume":"20","author":"Phillips","year":"2020","journal-title":"Pancreatology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.pan.2017.07.006","article-title":"Guidelines for the understanding and management of pain in chronic pancreatitis","volume":"17","author":"Drewes","year":"2017","journal-title":"Pancreatology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/ajg.2017.42","article-title":"Quality of Life in Chronic Pancreatitis is Determined by Constant Pain, Disability\/Unemployment, Current Smoking, and Associated Co-Morbidities","volume":"112","author":"Machicado","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1111\/j.1572-0241.1999.01075.x","article-title":"Incidence of cancer in the course of chronic pancreatitis","volume":"94","author":"Talamini","year":"1999","journal-title":"Am. J. Gastroenterol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/gut.51.6.849","article-title":"Risk of pancreatic adenocarcinoma in chronic pancreatitis","volume":"51","author":"Malka","year":"2002","journal-title":"Gut"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1053\/j.gastro.2013.12.033","article-title":"Mortality, cancer, and comorbidities associated with chronic pancreatitis: A Danish nationwide matched-cohort study","volume":"146","author":"Bang","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1007\/s00535-010-0242-4","article-title":"The revised Japanese clinical diagnostic criteria for chronic pancreatitis","volume":"45","author":"Shimosegawa","year":"2010","journal-title":"J. Gastroenterol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1136\/gut.25.10.1107","article-title":"Pancreatography in chronic pancreatitis: International definitions","volume":"25","author":"Axon","year":"1984","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.pan.2018.08.012","article-title":"Guidelines for the Diagnostic Cross Sectional Imaging and Severity Scoring of Chronic Pancreatitis","volume":"18","author":"Frokjaer","year":"2018","journal-title":"Pancreatology"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Yoshida, T., Yamashita, Y., and Kitano, M. (2019). Endoscopic Ultrasound for Early Diagnosis of Pancreatic Cancer. Diagnostics, 9.","DOI":"10.3390\/diagnostics9030081"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.pan.2018.09.016","article-title":"Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis","volume":"18","author":"Drewes","year":"2018","journal-title":"Pancreatology"},{"key":"ref_12","first-page":"1","article-title":"Diagnosis of early chronic pancreatitis by endoscopic ultrasound. Are we there yet?","volume":"5","author":"Raimondo","year":"2004","journal-title":"JOP"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.gie.2008.07.043","article-title":"EUS-based criteria for the diagnosis of chronic pancreatitis: The Rosemont classification","volume":"69","author":"Catalano","year":"2009","journal-title":"Gastrointest. Endosc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1052-5157(18)30401-X","article-title":"Endoscopic ultrasonography in chronic pancreatitis","volume":"5","author":"Dancygier","year":"1995","journal-title":"Gastrointest. Endosc. Clin. N. Am."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"A111","DOI":"10.1055\/s-2007-1001489","article-title":"Diagnosis of chronic pancreatitis by endoscopic ultrasonography","volume":"30","author":"Catalano","year":"1998","journal-title":"Endoscopy"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0016-5107(98)70123-3","article-title":"Prospective assessment of the ability of endoscopic ultrasound to diagnose, exclude, or establish the severity of chronic pancreatitis found by endoscopic retrograde cholangiopancreatography","volume":"48","author":"Sahai","year":"1998","journal-title":"Gastrointest. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0016-5107(98)70122-1","article-title":"Prospective evaluation of endoscopic ultrasonography, endoscopic retrograde pancreatography, and secretin test in the diagnosis of chronic pancreatitis","volume":"48","author":"Catalano","year":"1998","journal-title":"Gastrointest. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1440-1746.2004.03468.x","article-title":"Quantitative analysis of endosonographic parenchymal echogenicity in patients with chronic pancreatitis","volume":"19","author":"Irisawa","year":"2004","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/s00535-006-1916-9","article-title":"Usefulness of endoscopic ultrasound to diagnose the severity of chronic pancreatitis","volume":"42","author":"Irisawa","year":"2007","journal-title":"J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/MPA.0b013e31823b5978","article-title":"Endoscopic ultrasonography of the pancreas as an indirect method to predict pancreatic exocrine insufficiency in patients with chronic pancreatitis","volume":"41","author":"Nieto","year":"2012","journal-title":"Pancreas"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"110","DOI":"10.4103\/2303-9027.209870","article-title":"Significance of normal appearance on endoscopic ultrasonography in the diagnosis of early chronic pancreatitis","volume":"7","author":"Sato","year":"2018","journal-title":"Endosc. Ultrasound"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1038\/ajg.2010.274","article-title":"Endoscopic ultrasound, secretin endoscopic pancreatic function test, and histology: Correlation in chronic pancreatitis","volume":"105","author":"Albashir","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.gie.2006.12.043","article-title":"Histopathologic correlates of noncalcific chronic pancreatitis by EUS: A prospective tissue characterization study","volume":"66","author":"Varadarajulu","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0016-5107(04)02758-0","article-title":"Age-related changes in the pancreas identified by EUS: A prospective evaluation","volume":"61","author":"Rajan","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/gast.1996.v111.pm8698203","article-title":"Course of alcoholic chronic pancreatitis: A prospective clinicomorphological long-term study","volume":"111","author":"Ammann","year":"1996","journal-title":"Gastroenterology"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/MPA.0000000000000237","article-title":"American Pancreatic Association Practice Guidelines in Chronic Pancreatitis: Evidence-based report on diagnostic guidelines","volume":"43","author":"Conwell","year":"2014","journal-title":"Pancreas"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/2050640616684695","article-title":"United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU)","volume":"5","author":"Lohr","year":"2017","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.pan.2016.02.001","article-title":"Chronic pancreatitis: An international draft consensus proposal for a new mechanistic definition","volume":"16","author":"Whitcomb","year":"2016","journal-title":"Pancreatology"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Whitcomb, D.C., Shimosegawa, T., Chari, S.T., Forsmark, C.E., Frulloni, L., Garg, P., Hegyi, P., Hirooka, Y., Irisawa, A., and Ishikawa, T. (2018). International consensus statements on early chronic Pancreatitis. Recommendations from the working group for the international consensus guidelines for chronic pancreatitis in collaboration with The International Association of Pancreatology, American Pancreatic Association, Japan Pancreas Society, PancreasFest Working Group and European Pancreatic Club. Pancreatology.","DOI":"10.1016\/j.pan.2018.05.008"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1007\/s00535-019-01602-9","article-title":"Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria","volume":"54","author":"Masamune","year":"2019","journal-title":"J. Gastroenterol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3164\/jcbn.17-41","article-title":"Epigastric pain syndrome accompanying pancreatic enzyme abnormalities was overlapped with early chronic pancreatitis using endosonography","volume":"61","author":"Hashimoto","year":"2017","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000492813","article-title":"Camostat Mesilate, Pancrelipase, and Rabeprazole Combination Therapy Improves Epigastric Pain in Early Chronic Pancreatitis and Functional Dyspepsia with Pancreatic Enzyme Abnormalities","volume":"99","author":"Yamawaki","year":"2019","journal-title":"Digestion"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.pan.2018.08.002","article-title":"The diagnostic value of Rosemont and Japanese diagnostic criteria for \u2018indeterminate\u2019, \u2018suggestive\u2019, \u2018possible\u2019 and \u2018early\u2019 chronic pancreatitis","volume":"18","author":"Sheel","year":"2018","journal-title":"Pancreatology"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2958\/suizo.34.282","article-title":"Clinical Diagnostic Criteria for Chronic Pancreatitis 2019","volume":"34","author":"Masamune","year":"2019","journal-title":"Suizo"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41424-018-0069-5","article-title":"SPINK1, PRSS1, CTRC, and CFTR Genotypes Influence Disease Onset and Clinical Outcomes in Chronic Pancreatitis","volume":"9","author":"Zou","year":"2018","journal-title":"Clin. Transl. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.dld.2019.07.004","article-title":"Meta-analysis of the impact of the SPINK1 c.194+2T>C variant in chronic pancreatitis","volume":"52","author":"Tang","year":"2020","journal-title":"Dig. Liver Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5152\/tjg.2015.4287","article-title":"Mutation analysis of PRSS1, SPINK1 and CFTR gene in patients with alcoholic and idiopathic chronic pancreatitis: A single center study","volume":"26","author":"Sisman","year":"2015","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1007\/s00535-017-1388-0","article-title":"Nationwide survey of hereditary pancreatitis in Japan","volume":"53","author":"Masamune","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/jamapediatrics.2015.4955","article-title":"Risk Factors Associated With Pediatric Acute Recurrent and Chronic Pancreatitis: Lessons From INSPPIRE","volume":"170","author":"Kumar","year":"2016","journal-title":"JAMA Pediatr."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpeds.2017.03.063","article-title":"Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations","volume":"186","author":"Giefer","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.pan.2020.04.008","article-title":"Magnetic resonance cholangiopancreatography findings in early chronic pancreatitis diagnosed according to the Japanese Diagnostic Criteria","volume":"20","author":"Ito","year":"2020","journal-title":"Pancreatology"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/MCG.0b013e3181f42d69","article-title":"Interobserver agreement for pancreatic endoscopic ultrasonography determined by same day back-to-back examinations","volume":"45","author":"Gardner","year":"2011","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.gie.2009.10.043","article-title":"Multicenter comparison of the interobserver agreement of standard EUS scoring and Rosemont classification scoring for diagnosis of chronic pancreatitis","volume":"71","author":"Stevens","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Koh, C.J., Lakhtakia, S., Kida, M., Lesmana, C.R.A., Ang, T.L., Vu, C.K.F., Aye, T.T., Park, S.H., Almadi, M.A., and Chong, C.C. (2020). Defining the endoscopic ultrasound features of chronic pancreatitis in Asians: A multicenter validation study. Endoscopy.","DOI":"10.1055\/a-1217-3112"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.4103\/eus.eus_75_17","article-title":"Technique of qualitative and semiquantitative EUS elastography in pancreatic examination","volume":"6","author":"Costache","year":"2017","journal-title":"Endosc. Ultrasound"},{"key":"ref_46","first-page":"253","article-title":"Effect of aging and diffuse chronic pancreatitis on pancreas elasticity evaluated using semiquantitative EUS elastography","volume":"35","author":"Janssen","year":"2014","journal-title":"Ultraschall Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.gie.2014.06.040","article-title":"EUS elastography to predict pancreatic exocrine insufficiency in patients with chronic pancreatitis","volume":"81","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_48","first-page":"511","article-title":"Predicting Pancreatic Exocrine Insufficiency with EUS Elastography","volume":"12","year":"2016","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/jgh.13649","article-title":"Diagnostic efficacy of quantitative endoscopic ultrasound elastography for differentiating pancreatic disease","volume":"32","author":"Kim","year":"2017","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s00535-016-1296-8","article-title":"Quantitative diagnosis of chronic pancreatitis using EUS elastography","volume":"52","author":"Kuwahara","year":"2017","journal-title":"J. Gastroenterol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00535-011-0491-x","article-title":"Acoustic radiation force impulse elastography for noninvasive assessment of chronic pancreatitis","volume":"47","author":"Yashima","year":"2012","journal-title":"J. Gastroenterol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ejrad.2016.10.019","article-title":"Acoustic radiation force impulse shear wave elastography (ARFI) of acute and chronic pancreatitis and pancreatic tumor","volume":"85","author":"Goertz","year":"2016","journal-title":"Eur. J. Radiol."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Yamashita, Y., Tanioka, K., Kawaji, Y., Tamura, T., Nuta, J., Hatamaru, K., Itonaga, M., Yoshida, T., Ida, Y., and Maekita, T. (2019). Utility of Elastography with Endoscopic Ultrasonography Shear-Wave Measurement for Diagnosing Chronic Pancreatitis. Gut Liver.","DOI":"10.5009\/gnl19170"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1007\/s00261-019-02049-5","article-title":"Magnetic resonance imaging as a non-invasive method for the assessment of pancreatic fibrosis (MINIMAP): A comprehensive study design from the consortium for the study of chronic pancreatitis, diabetes, and pancreatic cancer","volume":"44","author":"Tirkes","year":"2019","journal-title":"Abdom. Radiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.gie.2020.04.071","article-title":"Deep learning-based pancreas segmentation and station recognition system in EUS: Development and validation of a useful training tool (with video)","volume":"92","author":"Zhang","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kuwahara, T., Hara, K., Mizuno, N., Haba, S., Okuno, N., Koda, H., Miyano, A., and Fumihara, D. (2020). Current status of artificial intelligence analysis for endoscopic ultrasonography. Dig. Endosc.","DOI":"10.1111\/den.13880"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/12\/1018\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:38:39Z","timestamp":1760179119000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/12\/1018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,27]]},"references-count":56,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["diagnostics10121018"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10121018","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,27]]}}}