{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:26:03Z","timestamp":1760239563766,"version":"build-2065373602"},"reference-count":10,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Tuberous sclerosis complex (TSC) is a rare autosomal dominant neurocutaneous syndrome. The phenotype is highly variable and may affect several organ systems, the hallmark of the disease being widespread hamartomas or abnormal growth of normal tissues. Although cardiac rhabdomyomas are the most common cardiac manifestation of TSC, being developed quite early, even during the second semester of the gestation, they tend to regress spontaneously over a period of months or years. On the other hand, the presence of intramyocardial fat deposition has been significantly associated with brain involvement and other extracardiac manifestations. We report the case of a 37-year-old man with TSC who presented to hospital with loss of consciousness, head injury and amnesia and in whom cardiac magnetic resonance imaging revealed the presence of multiple areas intramyocardial fat deposition.<\/jats:p>","DOI":"10.3390\/diagnostics10121031","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T20:06:09Z","timestamp":1606853169000},"page":"1031","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Magnetic Resonance Imaging of Intramyocardial Fat Deposition in Tuberous Sclerosis"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-8756","authenticated-orcid":false,"given":"Zoi","family":"Tsoumani","sequence":"first","affiliation":[{"name":"Cardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Greaves","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester M13 9PL, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Nucifora","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijcard.2010.09.090","article-title":"Lipomatous metaplasia in ischemic cardiomyopathy: Current knowledge and clinical perspective","volume":"146","author":"Nucifora","year":"2011","journal-title":"Int. J. Cardiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10554-011-9886-2","article-title":"Fat in left ventricular myocardium assessed by steady-state free precession pulse sequences","volume":"28","author":"Aquaro","year":"2012","journal-title":"Int. J. Cardiovasc. Imaging"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e001493","DOI":"10.1161\/JAHA.114.001493","article-title":"Cardiovascular Manifestations of Tuberous Sclerosis Complex and Summary of the Revised Diagnostic Criteria and Surveillance and Management Recommendations from the International Tuberous Sclerosis Consensus Group","volume":"3","author":"Hinton","year":"2014","journal-title":"JAHA"},{"key":"ref_4","first-page":"420","article-title":"Left ventricular giant rhabdomyoma in an infant with no tuberous sclerosis: Accidental finding and complex management","volume":"52","author":"Bassareo","year":"2010","journal-title":"Turk. J. Pediatr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1148\/radiol.2533082118","article-title":"Fatty Foci in the Myocardium in Patients with Tuberous Sclerosis Complex: Common Finding at CT","volume":"253","author":"Adriaensen","year":"2009","journal-title":"Radiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1002\/ajmg.a.36037","article-title":"Cardiac fat-containing lesions are common in tuberous sclerosis complex","volume":"161","author":"Shaaya","year":"2013","journal-title":"Am. J. Med. Genet."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1148\/radiol.2015141890","article-title":"Myocardial Fatty Foci in Adult Patients with Tuberous Sclerosis Complex: Association with Gene Mutation and Multiorgan Involvement","volume":"277","author":"Tresoldi","year":"2015","journal-title":"Radiology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1136\/jcp.2010.087676","article-title":"Mature fat cells in the myocardium of patients with tuberous sclerosis complex","volume":"64","author":"Adriaensen","year":"2011","journal-title":"J. Clin. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/5610347","article-title":"Fatty Images of the Heart: Spectrum of Normal and Pathological Findings by Computed Tomography and Cardiac Magnetic Resonance Imaging","volume":"2018","author":"Cannavale","year":"2018","journal-title":"Biomed Res. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1148\/rg.306105519","article-title":"Myocardial Fat at Cardiac Imaging: How Can We Differentiate Pathologic from Physiologic Fatty Infiltration?","volume":"30","author":"Kimura","year":"2010","journal-title":"RadioGraphics"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/12\/1031\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:40:20Z","timestamp":1760179220000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/10\/12\/1031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":10,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["diagnostics10121031"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics10121031","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}