{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:24:45Z","timestamp":1781760285922,"version":"3.54.5"},"reference-count":39,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T00:00:00Z","timestamp":1609286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Swedish Dental Society","award":["-"],"award-info":[{"award-number":["-"]}]},{"DOI":"10.13039\/501100004047","name":"Karolinska Institutet","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100004047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010586","name":"Haukeland\u00a0Universitetssjukehus","doi-asserted-by":"publisher","award":["-"],"award-info":[{"award-number":["-"]}],"id":[{"id":"10.13039\/501100010586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Our knowledge of synovial tissues in patients that are scheduled for surgery as a result of temporomandibular joint (TMJ) disorders is limited. Characterising the protein profile, as well as mapping clinical preoperative variables, might increase our understanding of pathogenesis and forecast surgical outcome. A cohort of 100 patients with either disc displacement, osteoarthritis, or chronic inflammatory arthritis (CIA) was prospectively investigated for a set of preoperative clinical variables. During surgery, a synovial tissue biopsy was sampled and analysed via multi-analytic profiling. The surgical outcome was classified according to a predefined set of outcome criteria six months postoperatively. Higher concentrations of interleukin 8 (p = 0.049), matrix metalloproteinase 7 (p = 0.038), lumican (p = 0.037), and tissue inhibitor of metalloproteinase 2 (p = 0.015) were significantly related to an inferior surgical outcome. Several other proteins, which were not described earlier in the TMJ synovia, were detected but not related to surgical outcome. Bilateral masticatory muscle palpation pain had strong association to a poor outcome that was related to the diagnoses disc displacement and osteoarthritis. CIA and the patient-reported variable TMJ disability might be related to an unfavourable outcome according to the multivariate model. These findings of surgical predictors show potential in aiding clinical decision-making and they might enhance the understanding of aetiopathogenesis in TMJ disorders.<\/jats:p>","DOI":"10.3390\/diagnostics11010046","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T09:35:23Z","timestamp":1609320923000},"page":"46","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Synovial Tissue Proteins and Patient-Specific Variables as Predictive Factors for Temporomandibular Joint Surgery"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9429-1771","authenticated-orcid":false,"given":"Mattias","family":"Ulmner","sequence":"first","affiliation":[{"name":"Unit of Cranio- and Maxillofacial Surgery, Karolinska University Hospital, 171 76 Stockholm, Sweden"},{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4843-6260","authenticated-orcid":false,"given":"Rachael","family":"Sugars","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5248-9202","authenticated-orcid":false,"given":"Aron","family":"Naimi-Akbar","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"},{"name":"Health Technology Assessment-Odontology, Malm\u00f6 University, 205 06 Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolce","family":"Tudzarovski","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carina","family":"Kruger-Weiner","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"},{"name":"Department of Oral and Maxillofacial Surgery, Folktandv\u00e5rden Stockholm, Eastmaninstitutet, 113 24 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodil","family":"Lund","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Karolinska Institutet, 141 04 Huddinge, Sweden"},{"name":"Department of Clinical Dentistry, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway"},{"name":"Department of Oral and Maxillofacial Surgery, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1097\/j.pain.0000000000001348","article-title":"Long-term changes in biopsychosocial characteristics related to temporomandibular disorder: Findings from the OPPERA study","volume":"159","author":"Fillingim","year":"2018","journal-title":"Pain"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.ijom.2019.09.002","article-title":"Predictive factors in temporomandibular joint arthroscopy: A prospective cohort short-term outcome study","volume":"49","author":"Ulmner","year":"2020","journal-title":"Int. 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