{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:51:08Z","timestamp":1760161868272,"version":"build-2065373602"},"reference-count":15,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,2]],"date-time":"2021-01-02T00:00:00Z","timestamp":1609545600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Pericarditis may signal the presence of cancer, even in the absence of other clinical or paraclinical signs. Corollary, the following question arises: Could the discovery of a newly developed pericarditis be used in patients with known neoplasia as a marker of cancer progression? In an attempt to find an answer to this question, this two-centre study included 341 consecutive patients with a confirmed diagnosis of cancer and evidence of pericardial effusion at echocardiography and\/or CT\/MRI scan. The patients\u2019 data were collected retrospectively if they further fulfilled the following inclusion criteria: available medical data from confirmation of pericarditis until evidence of cancer progression or until at least 12 months without progression. The average age of the patients was 62.16 years (22\u201386 years), and the study comprised 44.28% males and 55.71% females. All types of the most common neoplasms were represented. The results showed that 85.33% of patients had cancer progression temporally linked to pericarditis. Of these, 41.64% had cancer progression within 18 months after the diagnosis of pericarditis with a median time to progression of 5.03 months, ranging from 0 to 17 months; 43.69% had progression within a maximum of 2 months before the diagnosis of pericarditis. Only 14.66% had no cancer progression during the observation period. We concluded that pericarditis could be a sensitive marker of cancer evolution that could be widely used as a follow-up investigation for cancer patients as a marker of progression or recidive.<\/jats:p>","DOI":"10.3390\/diagnostics11010058","type":"journal-article","created":{"date-parts":[[2021,1,3]],"date-time":"2021-01-03T19:54:46Z","timestamp":1609703686000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoplasia-Associated Pericarditis\u2014Predictor of Cancer Progression?"],"prefix":"10.3390","volume":"11","author":[{"given":"Anca","family":"Boldan","sequence":"first","affiliation":[{"name":"Oncomed Oncology Outpatient Clinic, 300239 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9838-744X","authenticated-orcid":false,"given":"Alina Gabriela","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Boldan","sequence":"additional","affiliation":[{"name":"University of Medicine and Pharmacy Timi\u0219oara Student, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-4500","authenticated-orcid":false,"given":"Laura","family":"Mazilu","sequence":"additional","affiliation":[{"name":"Department of Oncology, Faculty of Medicine, Ovidius University of Constanta, 900470 Constan\u021ba, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anca","family":"Tudor","sequence":"additional","affiliation":[{"name":"Discipline of Computer Science and Medical Biostatistics, University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorel","family":"Popovici","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin","family":"S\u0103ftescu","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin Tudor","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0218erban Mircea","family":"Negru","sequence":"additional","affiliation":[{"name":"Department of Oncology, University of Medicine and Pharmacy \u201cVictor Babe\u0219\u201d, 300041 Timi\u0219oara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/HCO.0000000000000335","article-title":"Primary tumors of the heart","volume":"31","author":"Lestuzzi","year":"2016","journal-title":"Curr. Opin. Cardiol."},{"key":"ref_2","unstructured":"Soman, B. (2020, December 02). Vijayaraghavan, Govindan Pericardial Involvement in Neoplastic Disease: Prevalence, Clinical Picture, Diagnosis and Treatment. Available online: https:\/\/www.escardio.org\/Journals\/E-Journal-of-Cardiology-Practice\/Volume-15\/Pericardial-involvement-in-neoplastic-disease-prevalence-clinical-picture-diagnosis-and-treatment."},{"key":"ref_3","unstructured":"(2020, December 02). 2015 ESC Guidelines for the Diagnosis and Management of Pericardial Diseases | European Heart Journal | Oxford Academic. Available online: https:\/\/academic.oup.com\/eurheartj\/article\/36\/42\/2921\/2293375."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s11886-019-1225-6","article-title":"Cancer Treatment-Associated Pericardial Disease: Epidemiology, Clinical Presentation, Diagnosis, and Management","volume":"21","author":"Ala","year":"2019","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Ghosh, A.K., Crake, T., Manisty, C., and Westwood, M. (2018). Pericardial Disease in Cancer Patients. Curr. Treat. Opt. Cardiovasc. Med., 20.","DOI":"10.1007\/s11936-018-0654-7"},{"key":"ref_6","unstructured":"(2020, December 02). Radiation Dose\u2013Volume Effects in the Heart-International Journal of Radiation Oncology, Biology, Physics. Available online: https:\/\/www.redjournal.org\/article\/S0360-3016(09)03290-8\/fulltext."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jnci.2015.07.005","article-title":"Radiation induced heart disease: Pathogenesis, management and review literature","volume":"27","author":"Madan","year":"2015","journal-title":"J. Egypt. Natl. 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Gray, Henry. 1918. Anatomy of the Human Body. Available online: https:\/\/www.bartleby.com\/107\/181.html."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/1\/58\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:06:21Z","timestamp":1760159181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/1\/58"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,2]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["diagnostics11010058"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11010058","relation":{},"ISSN":["2075-4418"],"issn-type":[{"type":"electronic","value":"2075-4418"}],"subject":[],"published":{"date-parts":[[2021,1,2]]}}}