{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T04:31:58Z","timestamp":1772685118868,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T00:00:00Z","timestamp":1610668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["1263880"],"award-info":[{"award-number":["1263880"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science, Innovation and Universities, Government of Spain.","award":["FPU17\/01619"],"award-info":[{"award-number":["FPU17\/01619"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Balance problems are one of the most frequent symptoms in patients with Fibromyalgia Syndrome (FMS). However, the extent and nature of this balance disorder are not known. The objective of this work was to determine the best evidence for the alteration of postural balance in patients with FMS and analyze differences with healthy controls. To meet this objective, a systematic review with meta-analysis was performed. A bibliographical search was carried out in PubMed Medline, Scopus, Web of Science, CINAHL and SciELO. Observational studies that assessed postural balance in patients with FMS compared to healthy subjects in baseline conditions, were selected. In a random-effect model, the pooled effect was calculated with the Standardized Mean Difference (SMD) and its 95% confidence interval (CI). Nineteen studies reporting data of 2347 participants (95% female) were included. FMS patients showed poor balance with a large effect on static (SMD = 1.578; 95% CI = 1.164, 1.992), dynamic (SMD = 0.946; 95% CI = 0.598, 1.294), functional balance (SMD = 1.138; 95% CI = 0.689, 1.588) and on balance confidence (SMD = 1.194; 95% CI = 0.914, 1.473). Analysis of the Sensory Organization Test showed large alteration of vestibular (SMD = 1.631; 95% CI = 0.467, 2.795) and visual scores (SMD = 1.317; 95% CI = 0.153, 2.481) compared to healthy controls. Patients with FMS showed worse scores for different measures of postural balance compared to healthy controls. Concretely, FMS patients appear to have poor vestibular and visual scores with a possible somatosensory dependence.<\/jats:p>","DOI":"10.3390\/diagnostics11010127","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:44:05Z","timestamp":1610714645000},"page":"127","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Alteration of Postural Balance in Patients with Fibromyalgia Syndrome\u2014A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"11","author":[{"given":"David","family":"N\u00fa\u00f1ez-Fuentes","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-5500","authenticated-orcid":false,"given":"Esteban","family":"Obrero-Gait\u00e1n","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7105-9865","authenticated-orcid":false,"given":"Noelia","family":"Zagalaz-Anula","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9103-9696","authenticated-orcid":false,"given":"Alfonso Javier","family":"Ib\u00e1\u00f1ez-Vera","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1989-2988","authenticated-orcid":false,"given":"Alexander","family":"Achalandabaso-Ochoa","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-8423","authenticated-orcid":false,"given":"Mar\u00eda del Carmen","family":"L\u00f3pez-Ruiz","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-1091","authenticated-orcid":false,"given":"Daniel","family":"Rodr\u00edguez-Almagro","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2546-6301","authenticated-orcid":false,"given":"Rafael","family":"Lomas-Vega","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, University of Ja\u00e9n, Paraje Las Lagunillas s\/n, 23071 Ja\u00e9n, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Cer\u00f3n Lorente, L., Garc\u00eda R\u00edos, M.C., Navarro Ledesma, S., Tapia Haro, R.M., Casas Barrag\u00e1n, A., Correa-Rodr\u00edguez, M., and Aguilar Ferr\u00e1ndiz, M.E. (2019). Functional Status and Body Mass Index in Postmenopausal Women with Fibromyalgia: A Case\u2013control Study. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16224540"},{"key":"ref_2","first-page":"F1000","article-title":"Physical therapy modalities for treating fibromyalgia","volume":"8","author":"DeSantana","year":"2019","journal-title":"F1000Research"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/08990220.2020.1765767","article-title":"Effect of sensory stimulation applied under the great toe on postural ability in patients with fibromyalgia","volume":"37","author":"Viseux","year":"2020","journal-title":"Somatosens. Mot. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Di Tella, M., Castelli, L., Colonna, F., Fusaro, E., Torta, R., Ardito, R.B., and Adenzato, M. (2015). Theory of mind and emotional functioning in Fibromyalgia syndrome: An investigation of the relationship between social cognition and executive function. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0116542"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1756-185X.2010.01567.x","article-title":"The use of opioids in fibromyalgia","volume":"14","author":"Ngian","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/426130","article-title":"Fibromyalgia Syndrome: Etiology, Pathogenesis, Diagnosis, and Treatment","volume":"2012","author":"Bellato","year":"2012","journal-title":"Pain Res. Treat."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15022","DOI":"10.1038\/nrdp.2015.22","article-title":"Fibromyalgia","volume":"1","author":"Ablin","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","article-title":"Worldwide Epidemiology of Fibromyalgia","volume":"17","author":"Queiroz","year":"2013","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4065\/mcp.2010.0738","article-title":"Improving the Recognition and Diagnosis of Fibromyalgia","volume":"86","author":"Arnold","year":"2011","journal-title":"Mayo Clin. Proc."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Wolfe, F., Walitt, B., Perrot, S., Rasker, J.J., and H\u00e4user, W. (2018). Fibromyalgia diagnosis and biased assessment: Sex, prevalence and bias. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0203755"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1477-7525-6-8","article-title":"Disability and quality of life in patients with fibromyalgia","volume":"6","author":"Verbunt","year":"2008","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Feliu-Soler, A., Borr\u00e0s, X., Pe\u00f1arrubia-Mar\u00eda, M.T., Rozadilla-Sacanell, A., D\u2019Amico, F., Moss-Morris, R., Howard, M.A., Fayed, N., Soriano-Mas, C., and Puebla-Guedea, M. (2016). Cost-utility and biological underpinnings of Mindfulness-Based Stress Reduction (MBSR) versus a psychoeducational programme (FibroQoL) for fibromyalgia: A 12-month randomised controlled trial (EUDAIMON study). BMC Complement. Altern. Med., 16.","DOI":"10.1186\/s12906-016-1068-2"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"ii7","DOI":"10.1093\/ageing\/afl077","article-title":"Postural orientation and equilibrium: What do we need to know about neural control of balance to prevent falls?","volume":"35","author":"Horak","year":"2006","journal-title":"Age Ageing"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1177\/0269215520911992","article-title":"Effectiveness of acupuncture vs. core stability training in balance and functional capacity of women with fibromyalgia: A randomized controlled trial","volume":"34","year":"2020","journal-title":"Clin. Rehabil."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Peinado-Rubia, A., Osuna-P\u00e9rez, M.C., Rodr\u00edguez-Almagro, D., Zagalaz-Anula, N., L\u00f3pez-Ruiz, M.C., and Lomas-Vega, R. (2020). Impaired Balance in Patients with Fibromyalgia Syndrome: Predictors of the Impact of This Disorder and Balance Confidence. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17093160"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5132802","DOI":"10.1155\/2019\/5132802","article-title":"Influence of a Cell-Phone Conversation on Balance Performance in Women with Fibromyalgia: A Cross-Sectional Descriptive Study","volume":"2019","author":"Villafaina","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"R120","DOI":"10.1186\/ar2783","article-title":"The Revised Fibromyalgia Impact Questionnaire (FIQR): Validation and psychometric properties","volume":"11","author":"Bennett","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/09593980802668050","article-title":"Pilot study assessing balance in women with fibromyalgia syndrome","volume":"25","author":"Russek","year":"2009","journal-title":"Physiother. Theory Pract."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) Group","volume":"283","author":"Stroup","year":"2000","journal-title":"J. Am. Med. Assoc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"62","author":"Moher","year":"2009","journal-title":"J. Clin. Epidemiol."},{"key":"ref_21","unstructured":"Higgins, J.P.T., and Green, S. (2011). Cochrane Handbook for Systematic Reviews of Intervention Version 5.1.0 [Updated March 2011], The Cochrane Collaboration."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hozo, S.P., Djulbegovic, B., and Hozo, I. (2005). Estimating the mean and variance from the median, range, and the size of a sample. BMC Med. Res. Methodol., 5.","DOI":"10.1186\/1471-2288-5-13"},{"key":"ref_23","unstructured":"Wells, G.A., Shea, B., O\u2019Connell, D., Peterson, J., Welch, V., Losos, M., and Tugwell, P. (2020, May 13). The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses. Available online: http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"Stang","year":"2010","journal-title":"Eur. J. Epidemiol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lo, C.K.-L., Mertz, D., and Loeb, M. (2014). Newcastle-Ottawa Scale: Comparing reviewers\u2019 to authors\u2019 assessments. BMC Med. Res. Methodol., 14.","DOI":"10.1186\/1471-2288-14-45"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/2046-4053-3-82","article-title":"A checklist designed to aid consistency and reproducibility of GRADE assessments: Development and pilot validation","volume":"3","author":"Meader","year":"2014","journal-title":"Syst. Rev."},{"key":"ref_27","unstructured":"Borenstein, M., Hedges, L., Higgins, J., and Rothstein, H. (2020, November 16). Comprehensive Meta-Analysis Software Version 3. Available online: https:\/\/www.meta-analysis.com\/."},{"key":"ref_28","unstructured":"Cooper, H., Hedges, L.V., and Valentine, J.C. (2009). The Handbook of Research Synthesis and Meta-Analysis, Russell Sage Foundation."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control. Clin. Trials"},{"key":"ref_30","unstructured":"Cohen, J. (1977). Statistical Power Analysis for the Behavioral Sciences, Academic Press."},{"key":"ref_31","first-page":"700","article-title":"Interpreting estimates of treatment effects: Implications for managed care","volume":"33","author":"Faraone","year":"2008","journal-title":"Pharm. Ther."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"R\u00fccker, G., and Schwarzer, G. (2020). Beyond the forest plot: The drapery plot. Res. Synth. Methods.","DOI":"10.1002\/jrsm.1410"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1258\/1355819021927674","article-title":"Statistical heterogeneity in systematic reviews of clinical trials: A critical appraisal of guidelines and practice","volume":"7","author":"Higgins","year":"2002","journal-title":"J. Health Serv. Res. Policy"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/S0895-4356(01)00377-8","article-title":"Funnel plots for detecting bias in meta-analysis: Guidelines on choice of axis","volume":"54","author":"Sterne","year":"2001","journal-title":"J. Clin. Epidemiol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test measures of funnel plot asymmetry","volume":"315","author":"Egger","year":"1997","journal-title":"BMJ"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0006-341X.2000.00455.x","article-title":"Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis","volume":"56","author":"Duval","year":"2000","journal-title":"Biometrics"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10067-012-2117-y","article-title":"Assessment of the relationship between postural stability and sleep quality in patients with fibromyalgia","volume":"32","author":"Akkaya","year":"2013","journal-title":"Clin. Rheumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00296-013-2908-8","article-title":"Are there differences in quality of life, symptomatology and functional capacity among different obesity classes in women with fibromyalgia? The al-\u00c1ndalus project","volume":"34","author":"Aparicio","year":"2014","journal-title":"Rheumatol. Int."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e016239","DOI":"10.1136\/bmjopen-2017-016239","article-title":"Balance deficiencies in women with fibromyalgia assessed using computerised dynamic posturography: A cross-sectional study in Spain","volume":"7","year":"2017","journal-title":"BMJ Open"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Sempere-Rubio, N., L\u00f3pez-Pascual, J., Aguilar-Rodr\u00edguez, M., Cort\u00e9s-Amador, S., Esp\u00ed-L\u00f3pez, G., Villarrasa-Sapi\u00f1a, I., and Serra-A\u00f1\u00f3, P. (2018). Characterization of postural control impairment in women with fibromyalgia. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0196575"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Sempere-Rubio, N., Aguilar-Rodr\u00edguez, M., Ingl\u00e9s, M., Izquierdo-Alventosa, R., and Serra-A\u00f1\u00f3, P. (2019). Physical Condition Factors that Predict a Better Quality of Life in Women with Fibromyalgia. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16173173"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3233\/NRE-172245","article-title":"Balance deficits in Chronic Fatigue Syndrome with and without fibromyalgia","volume":"42","author":"Serrador","year":"2018","journal-title":"NeuroRehabilitation"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clinbiomech.2017.03.011","article-title":"Static postural sway of women with and without fibromyalgia syndrome: A cross-sectional study","volume":"44","author":"Trevisan","year":"2017","journal-title":"Clin. Biomech."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5606\/tjr.2013.2668","article-title":"Is there a balance problem in hypermobile patients with fibromyalgia?","volume":"28","author":"Ulus","year":"2013","journal-title":"Turk. J. Rheumatol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.4274\/tftr.75428","article-title":"Knee Proprioception and Balance in Turkish Women With and Without Fibromyalgia Syndrome","volume":"59","author":"Ulus","year":"2013","journal-title":"Turk. J. Phys. Med. Rehabil."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1007\/s00296-019-04399-1","article-title":"Trunk position sense, postural stability, and spine posture in fibromyalgia","volume":"39","author":"Mete","year":"2019","journal-title":"Rheumatol. Int."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2522\/ptj.20050320","article-title":"A Comparison of Physical Functional Performance and Strength in Women with Fibromyalgia, Age-and Weight-Matched Controls, and Older Women Who Are Healthy","volume":"86","author":"Panton","year":"2006","journal-title":"Phys. Ther."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1249\/MSS.0000000000000445","article-title":"Fitness Testing in the Fibromyalgia Diagnosis","volume":"47","author":"Aparicio","year":"2015","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.clinbiomech.2018.10.009","article-title":"The influence of balance, physical disability, strength, mechanosensitivity and spinal mobility on physical activity at home, work and leisure time in women with fibromyalgia","volume":"60","author":"Valenza","year":"2018","journal-title":"Clin. Biomech."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fnhum.2017.00014","article-title":"Altered Functional Performance in Patients with Fibromyalgia","volume":"11","author":"Costa","year":"2017","journal-title":"Front. Hum. Neurosci."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.clinbiomech.2011.12.009","article-title":"Functional capacity, muscle strength and falls in women with fibromyalgia","volume":"27","author":"Leite","year":"2012","journal-title":"Clin. Biomech."},{"key":"ref_53","first-page":"16","article-title":"Fibromyalgia is associated with impaired balance and falls","volume":"15","author":"Jones","year":"2009","journal-title":"J. Clin. Rheumatol. Pract. Rep. Rheum. Musculoskelet. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1186\/ar3432","article-title":"Postural control deficits in people with fibromyalgia: A pilot study","volume":"13","author":"Jones","year":"2011","journal-title":"Arthritis Res. Ther."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1080\/14397595.2016.1259603","article-title":"The relationship between balance and vitamin 25(OH)D in fibromyalgia patients","volume":"27","author":"Altan","year":"2017","journal-title":"Mod. Rheumatol."},{"key":"ref_56","first-page":"149","article-title":"Postural control and balance self-efficacy in women with fibromyalgia: Are there differences?","volume":"51","author":"Muto","year":"2015","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref_57","first-page":"519","article-title":"Prevalence and impact of fibromyalgia on function and quality of life in individuals from the general population: Results from a nationwide study in Spain","volume":"26","author":"Mas","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-3-662-46450-2_5","article-title":"Central sensitization in humans: Assessment and pharmacology","volume":"227","year":"2015","journal-title":"Handb. Exp. Pharmacol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpsychores.2018.12.010","article-title":"Central sensitization in chronic pain and medically unexplained symptom research: A systematic review of definitions, operationalizations and measurement instruments","volume":"117","author":"Dries","year":"2019","journal-title":"J. Psychosom. Res."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/art.10893","article-title":"Neurophysiologic evidence for a central sensitization in patients with fibromyalgia","volume":"48","author":"Desmeules","year":"2003","journal-title":"Arthritis Rheum."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00281-018-0672-2","article-title":"Neurogenic inflammation in fibromyalgia","volume":"40","author":"Littlejohn","year":"2018","journal-title":"Semin. Immunopathol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-510X(02)00032-1","article-title":"Neurotologic manifestations of the fibromyalgia syndrome","volume":"196","author":"Bayazit","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"4004","DOI":"10.1523\/JNEUROSCI.0098-07.2007","article-title":"Accelerated brain gray matter loss in fibromyalgia patients: Premature aging of the brain?","volume":"27","author":"Kuchinad","year":"2007","journal-title":"J. Neurosci."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.semarthrit.2014.01.001","article-title":"Central sensitization in fibromyalgia? A systematic review on structural and functional brain MRI","volume":"44","author":"Cagnie","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_66","first-page":"CD010585","article-title":"Combination pharmacotherapy for the treatment of fibromyalgia in adults","volume":"2","author":"Thorpe","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Del-Moral-Garc\u00eda, M., Obrero-Gait\u00e1n, E., Rodr\u00edguez-Almagro, D., Rodr\u00edguez-Huguet, M., Osuna-P\u00e9rez, M.C., and Lomas-Vega, R. (2020). Effectiveness of Active Therapy-Based Training to Improve the Balance in Patients with Fibromyalgia: A Systematic Review with Meta-Analysis. J. Clin. Med., 9.","DOI":"10.3390\/jcm9113771"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Lomas-Vega, R., Rodr\u00edguez-Almagro, D., Peinado-Rubia, A.B., Zagalaz-Anula, N., Molina, F., Obrero-Gait\u00e1n, E., Ib\u00e1\u00f1ez-Vera, A.J., and Osuna-P\u00e9rez, M.C. (2020). Joint Assessment of Equilibrium and Neuromotor Function: A Validation Study in Patients with Fibromyalgia. Diagnostics, 10.","DOI":"10.3390\/diagnostics10121057"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/1\/127\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:11:27Z","timestamp":1760159487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/1\/127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,15]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1]]}},"alternative-id":["diagnostics11010127"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11010127","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,15]]}}}