{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T23:10:42Z","timestamp":1772665842740,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:00:00Z","timestamp":1610755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p &lt; 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p &lt; 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5\u00b0 nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (\u22120.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.<\/jats:p>","DOI":"10.3390\/diagnostics11010136","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T05:17:34Z","timestamp":1610947054000},"page":"136","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2710-1875","authenticated-orcid":false,"given":"Elvira","family":"Orduna-Hospital","sequence":"first","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Otero-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"Perdices","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5621-1937","authenticated-orcid":false,"given":"Ana","family":"S\u00e1nchez-Cano","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Department of Applied Physics, University of Zaragoza, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0798-5565","authenticated-orcid":false,"given":"Ana","family":"Boned-Murillo","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Department of Ophthalmology, Lozano Blesa University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Acha","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Department of Endocrinology, Miguel Servet University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-9997","authenticated-orcid":false,"given":"Isabel","family":"Pinilla","sequence":"additional","affiliation":[{"name":"Aragon Institute for Health Research (IIS Aragon), 50009 Zaragoza, Spain"},{"name":"Department of Ophthalmology, Lozano Blesa University Hospital, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.2337\/diacare.26.9.2653","article-title":"Diabetic retinopathy and diabetic macular edema: Pathophysiology, screening, and novel therapies","volume":"26","author":"Ciulla","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/0002-9394(61)91802-5","article-title":"Diabetic retinopathy","volume":"51","author":"Wolter","year":"1961","journal-title":"Am. 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