{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:58:09Z","timestamp":1762981089004,"version":"build-2065373602"},"reference-count":41,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG, NE 2136\/3-1"],"award-info":[{"award-number":["DFG, NE 2136\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pfizer Germany","award":["Pfizer GIP Inflammation Germany Research Initiative"],"award-info":[{"award-number":["Pfizer GIP Inflammation Germany Research Initiative"]}]},{"name":"Abbvie Deutschlang","award":["Delayed Gadolinium-enhanced MR Imaging of Cartilage - A pilot study to measure the effect of Adalimumab plus MTX versus Placebo plus MTX on cartilage in early RA patients (CAR-ERA) Study"],"award-info":[{"award-number":["Delayed Gadolinium-enhanced MR Imaging of Cartilage - A pilot study to measure the effect of Adalimumab plus MTX versus Placebo plus MTX on cartilage in early RA patients (CAR-ERA) Study"]}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1009"],"award-info":[{"award-number":["01EC1009"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medizinische Fakult\u00e4t, Heinrich Heine Universit\u00e4t D\u00fcsseldorf","award":["Clinician Scientist Program Stufe 1"],"award-info":[{"award-number":["Clinician Scientist Program Stufe 1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Even though cartilage loss is a known feature of psoriatic (PsA) and rheumatoid arthritis (RA), research is sparse on its role in the pathogenesis of PsA, its potential use for disease monitoring and for differentiation from RA. We therefore assessed the use of delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) to evaluate biochemical cartilage changes in metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints in PsA patients and compared these to RA patients. Materials and Methods: A total of 17 patients with active PsA and 20 patients with active RA were evaluated by high-resolution 3 Tesla dGEMRIC using a dedicated 16-channel hand coil. Images were analyzed by two independent raters for dGEMRIC indices and joint space width (JSW) at MCP and PIP joint levels. Results: No significant differences of dGEMRIC values could be found between both study populations (PsA 472.25 ms, RA 461.11 ms; p = 0.763). In all RA and most PsA patients, PIP joints showed significantly lower dGEMRIC indices than MCP joints (RA: D2: p = 0.009, D3: p = 0.008, D4: p = 0.002, D5: p = 0.002; PsA: D3: p = 0.001, D4: p = 0.004). Most joint spaces had similar widths in both disease entities and no significant differences were found. Conclusions: As evaluated by dGEMRIC, the molecular composition of the MCP and PIP joint cartilage of PsA patients is similar to that of RA patients, demonstrating the scientific and clinical feasibility of compositional magnetic resonance (MR) imaging in these disease entities. Patterns and severity of compositional cartilage degradation of the finger joints may therefore be assessed beyond mere morphology in PsA and RA patients.<\/jats:p>","DOI":"10.3390\/diagnostics11020147","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T12:16:18Z","timestamp":1611144978000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["DGEMRIC in the Assessment of Pre-Morphological Cartilage Degeneration in Rheumatic Disease: Rheumatoid Arthritis vs. Psoriatic Arthritis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8116-4431","authenticated-orcid":false,"given":"Daniel B.","family":"Abrar","sequence":"first","affiliation":[{"name":"Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schleich","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5197-6861","authenticated-orcid":false,"given":"Miriam","family":"Frenken","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Vordenb\u00e4umen","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit for Rheumatology, Heinrich Heine University D\u00fcsseldorf, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Richter","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit for Rheumatology, Heinrich Heine University D\u00fcsseldorf, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit for Rheumatology, Heinrich Heine University D\u00fcsseldorf, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Ostendorf","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit for Rheumatology, Heinrich Heine University D\u00fcsseldorf, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5267-9962","authenticated-orcid":false,"given":"Sven","family":"Nebelung","sequence":"additional","affiliation":[{"name":"Medical Faculty, Department of Diagnostic and Interventional Radiology, University Dusseldorf, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8465-6207","authenticated-orcid":false,"given":"Philipp","family":"Sewerin","sequence":"additional","affiliation":[{"name":"Department and Hiller Research Unit for Rheumatology, Heinrich Heine University D\u00fcsseldorf, Moorenstrasse 5, 40225 D\u00fcsseldorf, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1478-6354-13-S1-S4","article-title":"Structural damage in rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: Traditional views, novel insights gained from TNF blockade, and concepts for the future","volume":"13","author":"Schett","year":"2011","journal-title":"Arthritis Res. 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