{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:48:34Z","timestamp":1760233714929,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T00:00:00Z","timestamp":1612310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009687","name":"Wroclaw Medical University","doi-asserted-by":"publisher","award":["SUB.C160.19.055"],"award-info":[{"award-number":["SUB.C160.19.055"]}],"id":[{"id":"10.13039\/501100009687","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Background: Metabolic acidosis in patients with chronic kidney disease (CKD) is a common complication. A bicarbonate concentration in venous blood (V-HCO3\u2212) is a key index for diagnosis and treatment initiation. The aim of our study is to evaluate usability of acid\u2013base balance parameters of in blood taken simultaneously from peripheral artery and the vein. Methods: A total of 49 patients (median age 66 years [interquartile range IQR 45\u201375]), with CKD stage G4 or G5 were enrolled in this cross-sectional study. All patients were qualified for arteriovenous fistula creation in pre-dialysis period. The samples were taken during surgery, directly after dissection, and evaluated in a point of care testing analyzer. The arteriovenous difference in bicarbonate levels (\u0394-HCO3\u2212) was calculated. According to glomerular filtration rate (eGFR) the group was divided into Group A eGFR \u2265 10 mL\/min\/1.73 m2) and Group B eGFR &lt; 10 mL\/min\/1.73 m2). Results: In Group A \u0394-HCO3\u2212 was significantly higher compared to Group B. No such differences were observed in the case of V-HCO3\u2212. \u0394-HCO3\u2212 positively correlated with eGFR. The discriminative power of \u0394-HCO3\u2212 for predicting eGFR &lt; 10 mL\/min\/1.73 m2 was 0.72 (95% confidence interval [CI] = 0.551\u20130.88; p = 0.01) which provided 67% sensitivity and 75% specificity. The best cut-off was 0.5 mmol\/L. Conclusions: The \u0394-HCO3\u2212 lower than 0.5 mmol\/L may be used as predictor of exhaust buffer capacity. The value of this tool should be tested in larger population.<\/jats:p>","DOI":"10.3390\/diagnostics11020226","type":"journal-article","created":{"date-parts":[[2021,2,3]],"date-time":"2021-02-03T11:54:31Z","timestamp":1612353271000},"page":"226","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Exhausted Capacity of Bicarbonate Buffer in Renal Failure Diagnosed Using Point of Care Analyzer"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5477-2020","authenticated-orcid":false,"given":"Tomasz","family":"Go\u0142\u0119biowski","sequence":"first","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6502-0374","authenticated-orcid":false,"given":"Mariusz","family":"Kusztal","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4966-9771","authenticated-orcid":false,"given":"Andrzej","family":"Konieczny","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Kuriata-Kordek","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5625-8156","authenticated-orcid":false,"given":"Ada","family":"Gawry\u015b","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3969-396X","authenticated-orcid":false,"given":"Hanna","family":"Augustyniak-Bartosik","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2747-8851","authenticated-orcid":false,"given":"Krzysztof","family":"Letachowicz","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-2622","authenticated-orcid":false,"given":"Dorota","family":"Zieli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Wi\u015bniewska","sequence":"additional","affiliation":[{"name":"Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University, 70-214 Szczecin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Krajewska","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, 50-556 Wroclaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s00467-006-0194-3","article-title":"Energy homeostasis and cachexia in chronic kidney disease","volume":"21","author":"Mak","year":"2006","journal-title":"Pediatr. Nephrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1172\/JCI117668","article-title":"Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans","volume":"95","author":"Ballmer","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/ajh\/hpt133","article-title":"Plasma bicarbonate and odds of incident hypertension","volume":"26","author":"Mandel","year":"2013","journal-title":"Am. J. Hypertens."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00467-010-1564-4","article-title":"Consequences and therapy of the metabolic acidosis of chronic kidney disease","volume":"26","author":"Kraut","year":"2011","journal-title":"Pediatr. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.ajkd.2009.02.014","article-title":"Serum bicarbonate levels and the progression of kidney disease: A cohort study","volume":"54","author":"Shah","year":"2009","journal-title":"Am. J. Kidney Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1053\/j.ajkd.2010.03.023","article-title":"Serum bicarbonate and long-term outcomes in CKD","volume":"56","author":"Menon","year":"2010","journal-title":"Am. J. Kidney Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Abe, M., Akaishi, T., Shoji, M., Yamaguchi, T., Miki, T., Satoh, F., Takayama, S., Yamasaki, S., Kawaguchi, K., and Sato, H. (2020). Reno-protective effects of oral alkalizing agents in chronic kidney disease with aciduria: Protocol for a randomized cohort study. BMC Nephrol., 21.","DOI":"10.1186\/s12882-020-01807-8"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1523-1755.2004.00481.x","article-title":"Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease","volume":"65","author":"Eustace","year":"2004","journal-title":"Kidney Int."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1038\/ki.2010.348","article-title":"Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet","volume":"78","author":"Wesson","year":"2010","journal-title":"Kidney Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/j.ackd.2012.11.001","article-title":"Dietary acid load: A novel nutritional target in chronic kidney disease?","volume":"20","author":"Scialla","year":"2013","journal-title":"Adv. Chronic. Kidney Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1172\/JCI112344","article-title":"Metabolic acidosis stimulates protein degradation in rat muscle by a glucocorticoid-dependent mechanism","volume":"77","author":"May","year":"1986","journal-title":"J. Clin. Investig."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"714","DOI":"10.2215\/CJN.08340812","article-title":"Effects of oral sodium bicarbonate in patients with CKD","volume":"8","author":"Abramowitz","year":"2013","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ki.2010.129","article-title":"Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy","volume":"78","author":"Mahajan","year":"2010","journal-title":"Kidney Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: A new prediction equation. Modification of Diet in Renal Disease Study Group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.7326\/0003-4819-145-4-200608150-00004","article-title":"Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate","volume":"145","author":"Levey","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ki.2013.444","article-title":"Summary of KDIGO 2012 CKD Guideline: Behind the scenes, need for guidance, and a framework for moving forward","volume":"85","author":"Levin","year":"2014","journal-title":"Kidney Int."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2215\/CJN.00060505","article-title":"Effect of dietary protein intake on serum total CO2 concentration in chronic kidney disease: Modification of Diet in Renal Disease study findings","volume":"1","author":"Gennari","year":"2006","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"e8802","DOI":"10.1097\/MD.0000000000008802","article-title":"Metabolic acidosis of chronic kidney disease and subclinical cardiovascular disease markers: Friend or foe?","volume":"96","author":"Capusa","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1681\/ASN.V581624","article-title":"Urinary organic anion excretion in response to dietary acid and base loading","volume":"5","author":"Packer","year":"1995","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/ki.2015.52","article-title":"Urinary ammonia and long-term outcomes in chronic kidney disease","volume":"88","author":"Vallet","year":"2015","journal-title":"Kidney Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1046\/j.1525-139x.2000.00070.x","article-title":"Disturbances of acid-base balance and bone disease in end-stage renal disease","volume":"13","author":"Kraut","year":"2000","journal-title":"Semin. Dial."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.ajkd.2013.01.017","article-title":"Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: A report from the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"62","author":"Dobre","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dobre, M., Yang, W., Pan, Q., Appel, L., Bellovich, K., Chen, J., Feldman, H., Fischer, M.J., Ham, L.L., and Hostetter, T. (2015). Persistent high serum bicarbonate and the risk of heart failure in patients with chronic kidney disease (CKD): A report from the Chronic Renal Insufficiency Cohort (CRIC) study. J. Am. 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