{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:44:47Z","timestamp":1781642687146,"version":"3.54.5"},"reference-count":26,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T00:00:00Z","timestamp":1612656000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3I0211, CMRPG3G1241, CFRPG6J0061"],"award-info":[{"award-number":["CMRPG3I0211, CMRPG3G1241, CFRPG6J0061"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-107-2314-B-182A-084-MY3"],"award-info":[{"award-number":["MOST-107-2314-B-182A-084-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>(1) Background: Patients with laryngeal cancer usually present with dysphonia. However, some studies reported that the duration from dysphonia to cancer diagnosis has been prolonged significantly in recent years. This study aimed to evaluate that in the initial dysphonia-related diagnosis and the interval between the diagnosis of laryngeal cancer may affect the overall survival (OS). (2) Methods: The 1997\u20132013 Longitudinal Health Insurance Database was used in this study. A propensity score with 1-to-1 matching was applied to balance the baseline characteristics. The OS was examined by the Kaplan-Meier method and log-rank test. (3) Results: A total of 2753 patients with a first primary laryngeal cancer diagnosis were identified. The patients without prior dysphonia-related diagnosis (PD\u2212) group did have a significantly worse five-year survival (p = 0.015) comparing with those with a prior dysphonia-related diagnosis (PD+) group among glottic cancer patients. The group with a shorter dysphonia-to-diagnosis interval had a better five-year OS than the prolonged group (p = 0.007) in laryngeal cancer. (4) Conclusions: Looking for medical assistance before a diagnosis of glottic cancer is associated with a better overall survival, while a diagnostic delay of more than 30 days from the first medical examination for dysphonia is associated with a worse outcome among in patients with laryngeal cancer.<\/jats:p>","DOI":"10.3390\/diagnostics11020255","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T20:51:51Z","timestamp":1612817511000},"page":"255","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Seeking Medical Assistance for Dysphonia Is Associated with an Improved Survival Rate in Laryngeal Cancer: Real-World Evidence"],"prefix":"10.3390","volume":"11","author":[{"given":"Yi-An","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-5940","authenticated-orcid":false,"given":"Ming-Shao","family":"Tsai","sequence":"additional","affiliation":[{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"},{"name":"Department of Otolaryngology Head and Neck Surgery, Chiayi Chang Gung Memorial Hospital, Chiayi 613, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-595X","authenticated-orcid":false,"given":"Li-Ang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-3996","authenticated-orcid":false,"given":"Shu-Ru","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Services Center for Health Information, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Yun","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chain-Fen","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan-Ni","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jen","family":"Hsin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Ta","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-3845","authenticated-orcid":false,"given":"Yu-Wen","family":"Wen","sequence":"additional","affiliation":[{"name":"Clinical Informatics and Medical Statistics Research Center, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuan-Jen","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, No. 5 Fushing St., Taoyuan 333, Taiwan"},{"name":"College of Medicine, Chang Gung University, Taoyuan 333, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.joms.2017.05.008","article-title":"Epidemiological trends of head and neck cancer in the United States: A SEER population study","volume":"75","author":"Mourad","year":"2017","journal-title":"J. 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