{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:34:19Z","timestamp":1775835259190,"version":"3.50.1"},"reference-count":23,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007181","name":"Quality Enhancement Research Initiative","doi-asserted-by":"publisher","award":["HX002263-01A1"],"award-info":[{"award-number":["HX002263-01A1"]}],"id":[{"id":"10.13039\/100007181","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Point-of-care lung ultrasound (LUS) is an attractive alternative to chest X-ray (CXR), but its diagnostic accuracy compared to CXR has not been well studied in coronavirus disease 2019 (COVID-19) patients. We conducted a prospective observational study to assess the correlation between LUS and CXR findings in COVID-19 patients. Ninety-six patients with a clinical diagnosis of COVID-19 underwent an LUS exam and CXR upon presentation. Physicians blinded to the CXR findings performed all LUS exams. Detection of pulmonary infiltrates by CXR versus LUS was compared between patients categorized as suspected or confirmed COVID-19 based on reverse transcriptase-polymerase chain reaction. Sensitivities and correlation by Kappa statistic were calculated between LUS and CXR. LUS detected pulmonary infiltrates more often than CXR in both suspected and confirmed COVID-19 subjects. The most common LUS abnormalities were discrete B-lines, confluent B-lines, and small subpleural consolidations. Most important, LUS detected unilateral or bilateral pulmonary infiltrates in 55% of subjects with a normal CXR. Substantial agreement was demonstrated between LUS and CXR for normal, unilateral or bilateral findings (\u039a = 0.48 (95% CI 0.34 to 0.63)). In patients with suspected or confirmed COVID-19, LUS detected pulmonary infiltrates more often than CXR, including more than half of the patients with a normal CXR.<\/jats:p>","DOI":"10.3390\/diagnostics11020373","type":"journal-article","created":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T14:23:27Z","timestamp":1614003807000},"page":"373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Comparison of Lung Ultrasound versus Chest X-ray for Detection of Pulmonary Infiltrates in COVID-19"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-4239","authenticated-orcid":false,"given":"Mar\u00eda","family":"Mateos Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Cristina, 28981 Parla, Madrid, Spain"},{"name":"Department of Medicine, Complutense University, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-7373","authenticated-orcid":false,"given":"Gonzalo","family":"Garc\u00eda de Casasola S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Cristina, 28981 Parla, Madrid, Spain"},{"name":"Department of Medicine, Complutense University, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4418-9223","authenticated-orcid":false,"given":"Francisco Javier Teigell","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Cristina, 28981 Parla, Madrid, Spain"},{"name":"Department of Medicine, Complutense University, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Proud","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"},{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Lourdo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital Universitario Infanta Cristina, 28981 Parla, Madrid, Spain"},{"name":"Department of Medicine, Complutense University, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia-Verena","family":"Sander","sequence":"additional","affiliation":[{"name":"M\u00e9dicins Sans Fronti\u00e8res, 08005 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel E. Ortiz","family":"Jaimes","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"},{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mader","sequence":"additional","affiliation":[{"name":"Research and Development Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-9721","authenticated-orcid":false,"given":"Jes\u00fas","family":"Canora Lebrato","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Fuenlabrada University Hospital, 28942 Fuenlabrada, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-3405","authenticated-orcid":false,"given":"Marcos I.","family":"Restrepo","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"},{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8460-0323","authenticated-orcid":false,"given":"Nilam J.","family":"Soni","sequence":"additional","affiliation":[{"name":"Section of Pulmonary and Critical Care Medicine, South Texas Veterans Health Care System, San Antonio, TX 78229, USA"},{"name":"Division of Pulmonary Diseases &amp; Critical Care Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"},{"name":"Division of General &amp; Hospital Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in wuhan, china","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Fang, Y., Zhang, H., Xie, J., Lin, M., Ying, L., Pang, P., and Ji, W. (2020). Sensitivity of chest ct for covid-19: Comparison to rt-pcr. Radiology, 200432.","DOI":"10.1148\/radiol.2020200432"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Ai, T., Yang, Z., Hou, H., Zhan, C., Chen, C., Lv, W., Tao, Q., Sun, Z., and Xia, L. (2020). Correlation of chest ct and rt-pcr testing in coronavirus disease 2019 (covid-19) in china: A report of 1014 cases. Radiology, 200642.","DOI":"10.1148\/radiol.2020200642"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108961","DOI":"10.1016\/j.ejrad.2020.108961","article-title":"Diagnosis of the coronavirus disease (covid-19): Rrt-pcr or ct?","volume":"126","author":"Long","year":"2020","journal-title":"Eur. J. Radiol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Wang, Y., Dong, C., Hu, Y., Li, C., Ren, Q., Zhang, X., Shi, H., and Zhou, M. (2020). Temporal changes of ct findings in 90 patients with covid-19 pneumonia: A longitudinal study. Radiology, 200843.","DOI":"10.1148\/radiol.2020200843"},{"key":"ref_6","unstructured":"American College or Radiology (2020, April 10). ACR Recommendations for the Use of Chest Radiography and Computed Tomography (ct) for Suspected Covid-19 Infection. Available online: https:\/\/www.acr.org\/Advocacy-and-Economics\/ACR-Position-Statements\/Recommendations-for-Chest-Radiography-and-CT-for-Suspected-COVID19-Infection."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.3346\/jkms.2020.35.e142","article-title":"Clinical course and outcomes of patients with severe acute respiratory syndrome coronavirus 2 infection: A preliminary report of the first 28 patients from the korean cohort study on covid-19","volume":"35","author":"Kim","year":"2020","journal-title":"J. Korean Med. Sci."},{"key":"ref_8","unstructured":"Wong, H.Y.F., Lam, H.Y.S., Fong, A.H., Leung, S.T., Chin, T.W., Lo, C.S.Y., Lui, M.M., Lee, J.C.Y., Chiu, K.W., and Chung, T. (2019). Frequency and distribution of chest radiographic findings in covid-19 positive patients. Radiology, 201160."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e707","DOI":"10.1097\/CCM.0000000000003129","article-title":"Diagnostic accuracy of chest radiograph, and when concomitantly studied lung ultrasound, in critically ill patients with respiratory symptoms: A systematic review and meta-analysis","volume":"46","author":"Winkler","year":"2018","journal-title":"Crit. Care Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Huang, Y., Wang, S., Liu, Y., Zhang, Y., Zheng, C., Zheng, Y., Zhang, C., Min, W., Zhou, H., and Yu, M. (2020, May 15). A Preliminary Study on the Ultrasonic Manifestations of Peripulmonary Lesions of Non-Critical Novel Coronavirus Pneumonia (Covid-19). Available online: https:\/\/ssrn.com\/abstract=3544750.","DOI":"10.2139\/ssrn.3544750"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1007\/s00134-020-05996-6","article-title":"Findings of lung ultrasonography of novel corona virus pneumonia during the 2019-2020 epidemic","volume":"46","author":"Peng","year":"2020","journal-title":"Intensive Care Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s13054-020-02876-9","article-title":"Lung ultrasound findings in patients with covid-19 pneumonia","volume":"24","author":"Xing","year":"2020","journal-title":"Crit. Care (Lond. Engl.)"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Poggiali, E., Dacrema, A., Bastoni, D., Tinelli, V., Demichele, E., Ramos, P.M., Marcian\u00f2, T., Silva, M., Vercelli, A., and Magnacavallo, A. (2020). Can lung us help critical care clinicians in the early diagnosis of novel coronavirus (covid-19) pneumonia?. Radiology, 200847.","DOI":"10.1148\/radiol.2020200847"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/jum.15285","article-title":"Proposal for international standardization of the use of lung ultrasound for covid-19 patients; a simple, quantitative, reproducible method","volume":"39","author":"Soldati","year":"2020","journal-title":"J. Ultrasound Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1002\/jum.15284","article-title":"Is there a role for lung ultrasound during the covid-19 pandemic?","volume":"39","author":"Soldati","year":"2020","journal-title":"J. Ultrasound Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13089-020-00171-w","article-title":"Sonographic signs and patterns of covid-19 pneumonia","volume":"12","author":"Volpicelli","year":"2020","journal-title":"Ultrasound J."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Yasukawa, K., and Minami, T. (2020). Point-of-care lung ultrasound findings in patients with novel coronavirus disease (covid-19) pneumonia. Am. J. Trop. Med. Hyg.","DOI":"10.4269\/ajtmh.20-0280"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"100231","DOI":"10.1016\/j.ejro.2020.100231","article-title":"Covid-19 pneumonia manifestations at the admission on chest ultrasound, radiographs, and ct: Single-center study and comprehensive radiologic literature review","volume":"7","author":"Lomoro","year":"2020","journal-title":"Eur. J. Radiol. Open"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1080\/02664769723918","article-title":"Interpretation of kappa and b statistics measures of agreement","volume":"24","author":"Munoz","year":"1997","journal-title":"J. Appl. Stat."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1002\/jmv.25855","article-title":"False-negative of rt-pcr and prolonged nucleic acid conversion in covid-19: Rather than recurrence","volume":"92","author":"Xiao","year":"2020","journal-title":"J. Med. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Mollura, D., and Lungren, M. (2013). Radiology in Global Health: Strategies, Implementation, and Applications, Springer.","DOI":"10.1007\/978-1-4614-0604-4"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13089-017-0059-y","article-title":"Systematic review and meta-analysis for the use of ultrasound versus radiology in diagnosing of pneumonia","volume":"9","author":"Alzahrani","year":"2017","journal-title":"Crit. Ultrasound J."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Volpicelli, G., Lamorte, A., and Vill\u00e9n, T. (2020). What\u2019s new in lung ultrasound during the covid-19 pandemic. Intensive Care Med., 1\u20134.","DOI":"10.1007\/s00134-020-06048-9"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/2\/373\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:28:02Z","timestamp":1760160482000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/2\/373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,22]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"alternative-id":["diagnostics11020373"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11020373","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,22]]}}}