{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:51:54Z","timestamp":1782312714565,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002878","name":"Consejer\u00eda de Econom\u00eda, Innovaci\u00f3n, Ciencia y Empleo, Junta de Andaluc\u00eda","doi-asserted-by":"publisher","award":["CTS-5360\/09"],"award-info":[{"award-number":["CTS-5360\/09"]}],"id":[{"id":"10.13039\/501100002878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["ISCIII 2013-RED 12-0043"],"award-info":[{"award-number":["ISCIII 2013-RED 12-0043"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases worldwide and it is associated with an increased risk of osteoporosis and fragility fractures. Our aim is to analyze the effect of T2DM on bone quality. This is a case-control study. The studied population consisted of 140 patients: 54 subjects with hip fracture (OP) without T2DM, 36 patients with hip fracture and T2DM (OP-T2DM), 28 patients with osteoarthritis (OA) without T2DM, and 22 patients with OA and T2DM (OA-T2DM). Bone markers, bone mineral density, FRAX score, microstructural, and bone material strength from femoral heads were assessed. The group with hip fracture presented lower BMD values than OA (p &lt; 0.05). The OP, OP-T2DM, and OA-T2DM groups showed a decrease in bone volume fraction (BV\/TV), in trabecular number (Tb.N), and in trabecular thickness (Tb.Th), while an increase was presented in the structural model index (SMI) and trabecular bone pattern factor (Tb.Pf), The groups OP, OP-T2DM, and OA-T2DM also presented lower values than those in group OA regarding the biomechanical parameters in the form of Young\u2019s modulus or elastic modulus, toughness, ultimate stress, ultimate load, extrinsic stiffness, and work to failure (p &lt; 0.05). Our results show the negative effect of type 2 diabetes mellitus on trabecular bone structure and mechanical properties.<\/jats:p>","DOI":"10.3390\/diagnostics11030577","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T14:08:16Z","timestamp":1616508496000},"page":"577","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Microstructural and Strength Changes in Trabecular Bone in Elderly Patients with Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8285-0767","authenticated-orcid":false,"given":"Merc\u00e8","family":"Giner","sequence":"first","affiliation":[{"name":"Departamento de Citolog\u00eda e Histolog\u00eda Normal y Patol\u00f3gica, Universidad de Sevilla, Avda. Dr. Fedriani s\/n, 41009 Sevilla, Spain"},{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Miranda","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Angeles","family":"V\u00e1zquez-G\u00e1mez","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"},{"name":"Medicine Department, University of Seville, Avda. Dr. Fedriani s\/n, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Altea-Manzano","sequence":"additional","affiliation":[{"name":"Medicine Department, University of Seville, Avda. Dr. Fedriani s\/n, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda-Jos\u00e9","family":"Miranda","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-8278","authenticated-orcid":false,"given":"Antonio","family":"Casado-D\u00edaz","sequence":"additional","affiliation":[{"name":"IMIBIC (Instituto Maim\u00f3nides de Investigaci\u00f3n Biom\u00e9dica de C\u00f3rdoba), Hospital Universitario Reina Sof\u00eda, Universidad de C\u00f3rdoba &amp; RETICEF, CIBERFES (ISCIII), 14004 C\u00f3rdoba, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"P\u00e9rez-Cano","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"},{"name":"Medicine Department, University of Seville, Avda. Dr. Fedriani s\/n, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4946-6667","authenticated-orcid":false,"given":"Mar\u00eda-Jos\u00e9","family":"Montoya-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Bone Metabolism Unit, Department of Internal Medicine, HUV Macarena, Avda S\u00e1nchez Pizju\u00e1n s\/n, 41009 Seville, Spain"},{"name":"Medicine Department, University of Seville, Avda. Dr. Fedriani s\/n, 41009 Sevilla, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1097\/MED.0b013e328331c7eb","article-title":"Diabetes and fractures: An overshadowed association","volume":"16","author":"Khazai","year":"2009","journal-title":"Curr. Opin. Endocrinol. 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Risk Manag."}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/3\/577\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:39:40Z","timestamp":1760161180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/3\/577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":35,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,3]]}},"alternative-id":["diagnostics11030577"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11030577","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}