{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:46:51Z","timestamp":1790545611449,"version":"4.1.0"},"reference-count":50,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T00:00:00Z","timestamp":1616544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>The aim of the present systematic review was to describe the gait pattern in people with multiple sclerosis (MS) by compiling the main findings obtained from studies using three-dimensional capture systems of human movement. The search was carried out in PubMed, Web of Science, Physiotherapy Evidence Database (PEDro), and the Cumulative Index to Nursing and Allied Health (CINAHL) databases. Studies that used three-dimensional gait analysis systems and that analyzed spatiotemporal, kinematic, kinetic, or electromyographic parameters, were included. The quality of the studies was assessed using the Critical Review Form\u2013Quantitative Studies scale. 12 articles were included with 523 (342 women and 181 men) people with a diagnosis of MS. The present work suggests that people with MS have a decrease in speed and stride length, as well as an increase in double-stance intervals during gait. Likewise, it is common to observe a decrease in hip extension during the stance period, a decrease in knee flexion in the swing period, a decrease in ankle dorsiflexion in the initial contact and a decrease in ankle plantar flexion during the pre-swing phase. The subjects with MS decrease the hip extensor moment and the ankle power during the stance period of walking.<\/jats:p>","DOI":"10.3390\/diagnostics11040584","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T15:42:19Z","timestamp":1616600539000},"page":"584","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Gait Pattern in People with Multiple Sclerosis: A Systematic Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9650-6158","authenticated-orcid":false,"given":"Mar\u00eda","family":"Coca-Tapia","sequence":"first","affiliation":[{"name":"Masters School, Rey Juan Carlos University, 28933 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9507-2717","authenticated-orcid":false,"given":"Alicia","family":"Cuesta-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Motion Analysis, Ergonomics, Biomechanics and Motor Control Laboratory (LAMBECOM), Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8616-5505","authenticated-orcid":false,"given":"Francisco","family":"Molina-Rueda","sequence":"additional","affiliation":[{"name":"Motion Analysis, Ergonomics, Biomechanics and Motor Control Laboratory (LAMBECOM), Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Carratal\u00e1-Tejada","sequence":"additional","affiliation":[{"name":"Motion Analysis, Ergonomics, Biomechanics and Motor Control Laboratory (LAMBECOM), Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Faculty of Health Sciences, Universidad Rey Juan Carlos, Alcorc\u00f3n, 28922 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,24]]},"reference":[{"key":"ref_1","first-page":"685","article-title":"Reliability and Minimal Detectable Change in the Gait Assessment and Intervention Tool in Patients with Multiple Sclerosis","volume":"12","author":"Daly","year":"2020","journal-title":"PMR"},{"key":"ref_2","first-page":"113","article-title":"Consensus statement on the treatment of multiple sclerosis by the Spanish Society of Neurology in 2016","volume":"32","author":"Merino","year":"2017","journal-title":"Neurolog\u00eda"},{"key":"ref_3","first-page":"623","article-title":"Situaci\u00f3n epidemiol\u00f3gica actual de la esclerosis m\u00faltiple: Pertinencia y puesta en marcha de un registro poblacional de nuevos casos en Catalu\u00f1a","volume":"50","author":"Batlle","year":"2010","journal-title":"Neurologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000111576","article-title":"The accuracy of prevalence rates of multiple sclerosis: A critical review","volume":"29","author":"Poser","year":"2007","journal-title":"Neuroepidemiology"},{"key":"ref_5","unstructured":"Instituto Nacional de Estad\u00edstica (2008). Encuesta Sobre Discapacidades, Autonom\u00eda Personal y Situaciones de Dependencia: EDAD 2008, INE."},{"key":"ref_6","first-page":"516","article-title":"Neurolog\u00eda y Medicina Interna Actualizaci\u00f3n: Esclerosis m\u00faltiple","volume":"11","author":"BowakimDib","year":"2001","journal-title":"Medifam"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1016\/j.med.2015.04.002","article-title":"Esclerosis M\u00faltiple","volume":"11","author":"Guerrero","year":"2015","journal-title":"Med. Programa Form. M\u00e9dica Contin. Acreditado"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1177\/1352458508088916","article-title":"Patient perception of bodily functions in multiple sclerosis: Gait and visual function are the most valuable","volume":"14","author":"Heesen","year":"2008","journal-title":"Mult. Scler."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/11591150-000000000-00000","article-title":"Impact of walking impairment in multiple sclerosis: Perspectives of patients and care partners","volume":"4","author":"Larocca","year":"2011","journal-title":"Patient"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0022-510X(11)70008-9","article-title":"Rehabilitation and multiple sclerosis: Hot topics in the preservation of physical functioning","volume":"311","author":"Dalgas","year":"2011","journal-title":"Neurol. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1056\/NEJM200009283431307","article-title":"Medical progress: Multiple sclerosis","volume":"343","author":"Noseworthy","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_12","first-page":"536","article-title":"Gait characteristics in multiple sclerosis: Progressive changes and effects of exercise on parameters","volume":"67","author":"Assmann","year":"1986","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.apmr.2015.07.018","article-title":"Observational Gait Assessments in People with Neurological Disorders: A Systematic Review","volume":"97","year":"2016","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1177\/1352458505070609","article-title":"Gait variability in people with multiple sclerosis","volume":"12","author":"Crenshaw","year":"2006","journal-title":"Mult. Scler."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/135245859900500510","article-title":"Gait abnormalities in minimally impaired multiple sclerosis patients","volume":"5","author":"Benedetti","year":"1999","journal-title":"Mult. Scler."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12984-015-0001-0","article-title":"Spatial and temporal characteristics of gait as outcome measures in multiple sclerosis (EDSS 0 to 6.5)","volume":"12","author":"Preiningerova","year":"2015","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_17","unstructured":"Law, M., Stewart, D., Pollicj, N., Letts, L., Bosch, J., and Westmorland, M. (1998). Guidelines for Critical Review Form-Quantitative Studies, McMaster University."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.medcli.2016.02.025","article-title":"The PRISMA statement extensi\u00f3n for systematic reviews incorporating network meta-analysis: PRISMA-NMA","volume":"147","author":"Hutton","year":"2016","journal-title":"Med. Clin."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.msard.2019.01.028","article-title":"Gait abnormalities in minimally disabled people with Multiple Sclerosis: A 3D-motion analysis study","volume":"29","author":"Liparoti","year":"2019","journal-title":"Mult. Scler. Relat. Disord."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12984-015-0028-2","article-title":"Association between perceived fatigue and gait parameters measured by an instrumented treadmill in people with multiple sclerosis: A cross-sectional study","volume":"12","author":"Kalron","year":"2015","journal-title":"J. Neuroeng. Rehabil."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/ptj\/pzy048","article-title":"Contributions of Ankle, Knee, Hip, and Trunk Muscle Function to Gait Performance in People with Multiple Sclerosis: A Cross-Sectional Analysis","volume":"98","author":"Hebert","year":"2018","journal-title":"Phys. Ther."},{"key":"ref_22","first-page":"1768","article-title":"The use of laboratory gait analysis for understanding gait deterioration in people with multiple sclerosis","volume":"14","author":"Khan","year":"2016","journal-title":"Mult. Scler."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1016\/j.gaitpost.2014.01.016","article-title":"Gait kinematics of people with Multiple Sclerosis and the acute application of Functional Electrical Stimulation","volume":"39","author":"Scott","year":"2014","journal-title":"Gait Posture"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-22676-0","article-title":"Profiling walking dysfunction in multiple sclerosis: Characterisation, classification and progression over time","volume":"8","author":"Filli","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clinbiomech.2017.04.001","article-title":"Evaluation of Clinical Gait Analysis parameters in patients affected by Multiple Sclerosis: Analysis of kinematics","volume":"45","author":"Severini","year":"2017","journal-title":"Clin. Biomech."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.gaitpost.2016.10.013","article-title":"Gait profile score in multiple sclerosis patients with low disability","volume":"51","author":"Morel","year":"2017","journal-title":"Gait Posture"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1123\/mc.2013-0106","article-title":"Time-to-contact analysis of gait stability in the swing phase of walking in people with multiple sclerosis","volume":"19","author":"Remelius","year":"2015","journal-title":"Motor Control"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jns.2015.09.352","article-title":"Effect of spasticity on kinematics of gait and muscular activation in people with multiple sclerosis","volume":"358","author":"Pau","year":"2015","journal-title":"J. Neurol. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.gaitpost.2013.07.124","article-title":"Gait and jogging parameters in people with minimally impaired multiple sclerosis","volume":"39","author":"Kalron","year":"2014","journal-title":"Gait Posture"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1123\/jab.29.3.303","article-title":"Gait mechanics are different between healthy controls and patients with multiple sclerosis","volume":"29","author":"Huisinga","year":"2012","journal-title":"J. Appl. Biomech."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.gaitpost.2012.10.012","article-title":"Gait variability and disability in multiple sclerosis","volume":"38","author":"Socie","year":"2012","journal-title":"Gait Posture"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"867575","DOI":"10.1155\/2013\/867575","article-title":"Quantifying gait impairment using an instrumented treadmill in people with multiple sclerosis","volume":"2013","author":"Kalron","year":"2013","journal-title":"ISRN Neurol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.gaitpost.2010.09.016","article-title":"Speed- and cane-related alterations in gait parameters in individuals with multiple sclerosis","volume":"33","author":"Gianfrancesco","year":"2011","journal-title":"Gait Posture"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3109\/09638280903464497","article-title":"The characterisation of gait patterns of people with multiple sclerosis","volume":"32","author":"Kelleher","year":"2010","journal-title":"Disabil. Rehabil."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.gaitpost.2008.07.011","article-title":"Gait analysis in multiple sclerosis: Characterization of temporal-spatial parameters using GAITRite functional ambulation system","volume":"29","author":"Givon","year":"2009","journal-title":"Gait Posture"},{"key":"ref_36","first-page":"433","article-title":"Instrumental gait analysis in stroke patients","volume":"63","year":"2016","journal-title":"Rev. Neurol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/apmr.2001.18584","article-title":"Reduced Hip Extension During Walking: Healthy Elderly and Fallers Versus Young Adults","volume":"82","author":"Lee","year":"2001","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1053\/apmr.2001.18219","article-title":"Age-Related changes in spatial and temporal gait variables","volume":"82","author":"Grabiner","year":"2001","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1177\/1352458512444497","article-title":"The relationship between upper leg muscle strength and walking capacity in persons with multiple sclerosis","volume":"19","author":"Broekmans","year":"2013","journal-title":"Mult. Scler."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.gaitpost.2013.05.003","article-title":"A method to differentiate the causes of stiff-knee gait in stroke patients","volume":"38","author":"Campanini","year":"2013","journal-title":"Gait Posture"},{"key":"ref_41","unstructured":"Tejada, M.C., and Rueda, F.M. (2020). Patr\u00f3n cin\u00e9tico y electromiogr\u00e1fico de la marcha. Biomec\u00e1nica, Evaluaci\u00f3n y Patolog\u00eda, Panamericana. [1st ed.]. La Marcha Humana."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3233\/NRE-192997","article-title":"An intensive task-oriented circuit training positively impacts gait biomechanics in MS patients","volume":"46","author":"Tramonti","year":"2020","journal-title":"NeuroRehabilitation"},{"key":"ref_43","first-page":"157","article-title":"Effectiveness of motor imagery in patients with multiple sclerosis: A systematic review","volume":"72","year":"2021","journal-title":"Rev. Neurol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.physio.2018.11.007","article-title":"Treadmill training may be an effective form of task-specific training for improving mobility in people with Parkinson\u2019s disease and multiple sclerosis: A systematic review and meta-analysis","volume":"105","author":"Robinson","year":"2019","journal-title":"Physiotherapy"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1007\/s00415-016-8200-6","article-title":"Gait characteristics according to pyramidal, sensory, and cerebellar EDSS subcategories in people with multiple sclerosis","volume":"263","author":"Kalron","year":"2016","journal-title":"J. Neurol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1249\/MSS.0b013e31817e32a3","article-title":"Leg power asymmetry and postural control in women with multiple sclerosis","volume":"40","author":"Chung","year":"2008","journal-title":"Med. Sci. Sports Exerc."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Sosnoff, J.J., Socie, M.J., Boes, M.K., Sandroff, B.M., Pula, J.H., Suh, Y., Weikert, M., Balantrapu, S., Morrison, S., and Motl, R.W. (2011). Mobility, Balance and Falls in Persons with Multiple Sclerosis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0028021"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1177\/1352458508096874","article-title":"Sensory impairments in quiet standing in subjects with multiple sclerosis","volume":"15","author":"Cattaneo","year":"2009","journal-title":"Mult. Scler."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.gaitpost.2010.09.002","article-title":"Postural control in women with multiple sclerosis: Effects of task, vision and symptomatic fatigue","volume":"32","author":"Remelius","year":"2010","journal-title":"Gait Posture"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Kalron, A., Givon, U., Frid, L., Dolev, M., and Achiron, A. (2016). Static Posturography and Falls According to Pyramidal, Sensory and Cerebellar Functional Systems in People with Multiple Sclerosis. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0164467"}],"container-title":["Diagnostics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/4\/584\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T05:40:28Z","timestamp":1760161228000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4418\/11\/4\/584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,24]]},"references-count":50,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["diagnostics11040584"],"URL":"https:\/\/doi.org\/10.3390\/diagnostics11040584","relation":{},"ISSN":["2075-4418"],"issn-type":[{"value":"2075-4418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,24]]}}}