{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:46:23Z","timestamp":1765039583328,"version":"build-2065373602"},"reference-count":54,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T00:00:00Z","timestamp":1618531200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Regional Development Fund Programme: Operational Programme \u2018Innovative economy\u2019 (2007-2013): \u2018Establishing a Research and Development Center of noninvasive therapeutic methods\u2019.","award":["POIG.04.05.02-00-075\/12-00"],"award-info":[{"award-number":["POIG.04.05.02-00-075\/12-00"]}]},{"name":"European Regional Development Fund Programme: Intelligent Development Operational Pro-gram (2014-2020): \u2018Development and implementation of a noninvasive, personalized thermo-ablation procedure in the treatment of specific types of neoplasms\u2019","award":["POIR.01.01.01-00-0019\/15-00"],"award-info":[{"award-number":["POIR.01.01.01-00-0019\/15-00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Objective: The assessment of the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) when qualifying patients with uterine fibroids (UFs) for magnetic resonance-guided high-intensity ultrasound (MR-HIFU). Material and methods: This retrospective, single center study included 283 women who underwent DCE-MRI and were treated with MR-HIFU. The patients were divided according to non-perfused volume (NPV) as well as by the type of curve for patients with a washout curve in the DCE-MRI study and patients without a washout curve. The studied women were assessed in three groups according to the type of uterotonics administered. Group A (57 patients) received one dose of misoprostol\/diclofenac transvaginally and group B (71 patients) received oxytocin intravenously prior to the MR-HIFU procedure. The remaining 155 women (group C) were treated with the traditional non-drug enhanced MR-HIFU procedure. Results: The average NPV value was higher in no washout group, and depended on the uterotonics used. Conclusions: We demonstrated a correlation between dynamic contrast enhancement curve types and the therapeutic efficacy of MR-HIFU. Our results suggest that DCE-MRI has the potential to assess treatment outcomes among patients with UFs, and patients with UFs that present with a washout curve may benefit from the use of uterotonic drugs. More studies are required to draw final conclusions.<\/jats:p>","DOI":"10.3390\/diagnostics11040715","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T10:20:11Z","timestamp":1618568411000},"page":"715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Magnetic Resonance-Guided High-Intensity Focused Ultrasound Ablation of Uterine Fibroids\u2014Efficiency Assessment with the Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging and the Potential Role of the Administration of Uterotonic Drugs"],"prefix":"10.3390","volume":"11","author":[{"given":"Tomasz","family":"\u0141ozi\u0144ski","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Pro-Familia Hospital, 35-302 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-5983","authenticated-orcid":false,"given":"Micha\u0142","family":"Ciebiera","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynecology, Center of Postgraduate Medical Education, 01-809 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4872-7172","authenticated-orcid":false,"given":"El\u017cbieta","family":"\u0141uczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Institute of Medical Sciences, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Filipowska","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Institute of Medical Sciences, Faculty of Medicine, University of Rzeszow, 35-310 Rzeszow, Poland"},{"name":"Department of Radiology, Pro-Familia Hospital, 35-302 Rzeszow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Czekierdowski","sequence":"additional","affiliation":[{"name":"Department of Gynecological Oncology and Gynecology, Medical University of Lublin, 20-081 Lublin, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.fertnstert.2007.01.093","article-title":"Etiology, symptomatology, and diagnosis of uterine myomas","volume":"87","author":"Parker","year":"2007","journal-title":"Fertil. 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