{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:24:04Z","timestamp":1787775844823,"version":"build-2784847793"},"reference-count":45,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Regional agreement in medical training and clinical research between Uppsala University Hospital and Uppsala County","award":["CK 2015-0112"],"award-info":[{"award-number":["CK 2015-0112"]}]},{"name":"Research Foundation of Margaretahemmet","award":["2017-00038"],"award-info":[{"award-number":["2017-00038"]}]},{"name":"Selander Foundation","award":["2018\/15"],"award-info":[{"award-number":["2018\/15"]}]},{"name":"SciLife PET-MR grant","award":["UFV 2016\/94"],"award-info":[{"award-number":["UFV 2016\/94"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostics"],"abstract":"<jats:p>Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBFASL) and 15O-water positron emission tomography (PET) (CBFPET) acquired simultaneously on an integrated 3T PET\/MR system. The data comprised ASL and dynamic 15O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years). 15O-water PET parametric CBF images were generated using a basis function implementation of the single tissue compartment model. Cortical and subcortical regions were automatically segmented using Freesurfer. Average CBFASL and CBFPET in grey matter were 60 \u00b1 20 and 75 \u00b1 22 mL\/100 g\/min respectively, with a relatively high correlation (r = 0.78, p &lt; 0.001). Bland-Altman analysis revealed poor agreement (bias = \u221215 mL\/100 g\/min, lower and upper limits of agreements = \u221216 and 45 mL\/100 g\/min, respectively) with a negative relationship. Accounting for the negative relationship, the width of the limits of agreement could be narrowed from 61 mL\/100 g\/min to 35 mL\/100 g\/min using regression-based limits of agreements. Although a high correlation between CBFASL and CBFPET was found, the agreement in absolute CBF values was not sufficient for ASL to be used interchangeably with 15O-water PET.<\/jats:p>","DOI":"10.3390\/diagnostics11050821","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T21:35:39Z","timestamp":1619904939000},"page":"821","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of Arterial Spin Labeling MRI\u2014Comparison with 15O-Water PET on an Integrated PET\/MR Scanner"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2502-6026","authenticated-orcid":false,"given":"Markus","family":"Fahlstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieuwe","family":"Appel","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kumlien","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Danfors","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Engstr\u00f6m","sequence":"additional","affiliation":[{"name":"Applied Science Laboratory, GE Healthcare, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-6857","authenticated-orcid":false,"given":"Johan","family":"Wikstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Antoni","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elna-Marie","family":"Larsson","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-7399","authenticated-orcid":false,"given":"Mark","family":"Lubberink","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,1]]},"reference":[{"key":"ref_1","first-page":"842","article-title":"Comparison of Cerebral Blood Flow Measurement with [15O]-Water Positron Emission Tomography and Arterial Spin Labeling Magnetic Resonance Imaging: A Systematic Review","volume":"36","author":"Fan","year":"2016","journal-title":"Br. 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